Sheriff's officials said the driver of a northbound car lost control on Highway 41 near Neenah and collided with the van about 4 p.m. Wednesday.
Authorities identified the deceased as Hannah Twomey, 15, and James Markham, 19, both of Appleton.
Two others in the car, both 18-year-old Appleton women, were taken to Theda Clark Medical Center, where one is in critical condition and the other in good condition, hospital officials said. The driver of the van was treated for injuries and released from Theda Clark.

