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Vaccination

Two of the most prominent figures in the debate over whether vaccines contribute to autism are coming to La Crosse.

Andrew Wakefield, the English doctor who championed the now-dismissed link between the measles-mumps-rubella vaccine and the onset of autism, and Brian Deer, the newspaper reporter who showed how the study’s findings were manipulated and embellished, will speak Thursday.

The appearances are already sparking controversy.

It started when University of Wisconsin-La Crosse biology faculty invited Deer to present as part of a yearly life sciences lecture series.

“We’re just a bunch of geeky scientists,” said Michael Winfrey, UW-L microbiology professor. “But this is getting all this publicity.”

Deer’s reporting  in the Sunday Times of London upended findings of a 1998 publication that linked the MMR vaccine with autism — findings since denounced by medical experts and the British journal that printed the report.

Neither Deer nor Wakefield could be immediately reached for comment Friday.

United Kingdom officials stripped Wakefield of his medical license, but he has since moved to the United States and maintains a groundswell of support from those who continue to believe his assertions.

“The way we see it, an innocent man has been accused wrongly and falsely,” said Patti Carroll, a volunteer for the Dr. Wakefield Justice Fund.

The group organized a response when it heard about Deer’s presentation at UW-L, Carroll said.

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Carroll stopped vaccinating her children when her son fell ill after receiving a vaccine and developed autism months later, she said.

“If Brian Deer is going to come to America and start trying to sell his story, people have a right to ask questions of the person he is accusing,” Carroll said.

Wakefield is scheduled to speak 1 p.m. at a location yet to be determined.

Deer is scheduled to speak at 5:30 p.m. Thursday and 3:30 p.m. Friday at UW-L’s Centennial Hall.

UW-L faculty invited Deer because they were intrigued by his findings and the landmark effect they had on the health profession, Winfrey said.

“There’s a number of scientific frauds that have been exposed,” Winfrey said.

In seven years of reporting for multiple publications, Deer exposed conflicts of interest Wakefield hid from fellow doctors and questionable practices he used to conduct his research.

UW-L has received several responses since inviting Deer to speak. Winfrey admits Deer’s work is controversial, despite overwhelming support from the scientific community.

“We are a university,” he said. “We value and encourage people to look at both sides of issues and make informed decisions.”

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(366) comments

Twyla

If any are still reading here - you may be interested to know that the Congressional Committee on Oversight and Government Reform held a hearing last week discussing the federal response to autism. Much of the hearing focused on vaccines and autism. The hearing was filmed by C-Span and is available to see here:
http://www.c-spanvideo.org/program/309672-1

Although quite long in total, it consists of short segments which can be easily accessed via the "Timeline". This hearing shows that the concerns which parents have been voicing for years are now becoming mainstream. These are powerful congresspeople – Republicans and Democrats – asking the difficult questions and expressing concern about a possible relationship between vaccines and autism, and about the failure of the federal government to take appropriate action.

Twyla

An excellent letter:

OPEN LETTER to the Sponsors of Brian Deer’s Lectures at The University of Wisconsin, La Crosse, October 2012
Written by Jennifer VanDerHorst Larson
Friday, 26 October 2012 09:07

http://canaryparty.net/index.php/the-news/118-open-letter-to-the-sponsors-of-brian-deers-lectures-at-the-university-of-wisconsin-la-crosse-october-2012

Twyla

In case the above link doesn't work, here is a link to Jennifer VanDerHorst Larson's excellent letter to Brian Deer at the Age of Autism site, where it is posted today:

Canary Party Responds To Brian Deer's Rebuttal
http://www.ageofautism.com/2012/10/canary-party-responds-to-brian-deer-rebuttal.html

Jennifer takes the time to respond to many of Brian Deer's statements in detail. In addition, there is embedded in this article a video of Dr. Wakefield speaking at Brandeis University.

Twyla

Please also see this same letter from Jennifer VanDerHorst Larson posted on Age of Autism today, along with a video of Dr. Wakefield speaking at Brandeis University.
http://www.ageofautism.com/2012/10/canary-party-responds-to-brian-deer-rebuttal.html

Taylor

I see that Brian Deer has posted an item at his website which seems to reply pretty much to everything here. Well done Mr Deer (but it took you long enough!)

http://briandeer.com/solved/vanderhorst-larson.htm

Mofmars333

Hardly a debate & why is that? Because every time one is arranged the pro vaccine side backs out when the pressure from those behind the cover up stop them because they cannot have the truth come out in public forum in that way. Now with the title of this article being so mis-leading it does set the playing field for a true debate which WILL NOT be escaped from due to the depth of bull Deer has stepped into. Not with the masses watching thanks to the Wakefield controversy where he knowingly sacrificed his career due to the fact he loves children more than money. The jig is up & Lying Brian Deer will have to debate. LOL. Mark my words & just watch!

Dyson

Well it is "not a debate" because Deer was scheduled to give his talk at the University about fraud and MMR, so Wakefield tried to hold a rally in competition to Deer's, where he could put his lame side of the story to a handful of acolytes, bused in as though it was a rally for a third world dictator's political speech. Debates are held with both parties present.

As for online debate - tell us why antivax/ProWakefield websites like Age of Autism ban all adverse comments, yet science based sites like science-based medicine and respectful insolence welcome debate and challenges to their viewpoints, and nobody is banned from commenting?

liquidambar

Dyson;
You have to be exhausted???
You were here was it Friday night really late and I checked back in and you are still here??? How is that possible?

I am curious about this too. You said they people at Wakefield's rally was buse in like a dicator of a third world country.
A dictator of a third world country has an army to pick them up and put them on the bus -- I don't think Wakefield has an army to do that. Perhaps he has tons of money??? That he just pays these parents to get on the bus???
Maybe he got some homeless people to get on the bus - he is going to offer them hotdogs --- wonder were he got the money for those hotdogs?

And where is those science =based medicine debates? Right Brian - Left Brian Haaaaaa a or other websites around that have poor parents of vaccine damage kids that just want to pour out thier hearts - to tell the tradegy to someone - to give details -- to find out what went wrong and why and we get hateful, smart alec remarks back in turn.

Dyson

Do you think the good people of La Crosse spontaneously turned up in the park to hear Wakers speak?
Maybe they bused some guys in from Hamilton.

As for money- he has the drwakefield justice fund, which has been raising money for him. Maybe he could use some to get a decent haircut.

Twyla

re: "As for online debate - tell us why antivax/ProWakefield websites like Age of Autism ban all adverse comments, yet science based sites like science-based medicine and respectful insolence welcome debate..."

Dyson, that is because the bloggers with concerns about vaccine are generally not mean spirited like many of the bloggers who are pro-vaccine. If AoA didn't filter comments, they would be over-run with hundreds of obnoxious comments. If Respectful Insolence is able to post all comments, that is a credit to the thoughtful, sincere people who have concerns about vaccines.

Also, anyone who ventures into Respectful Insolence with different opinions encounters so much meanness and closed-mindedness that they decide there is no point in posting there.

Science Mom

Dyson, that is because the bloggers with concerns about vaccine are generally not mean spirited like many of the bloggers who are pro-vaccine.

Bwahahaha! Oh yes everyone who pens an article and comments at AoA is so warm and fuzzy, relating their experiences with the utmost erudition, rationale and integrity. Yea right Twyla, pull the other one; it's got bells on it.

Twyla

Wakefield didn't just try to hold a rally. He held a rally. It wasn't like a third world dictator's speech. Parents organized and attended the rally because they are passionate about what happened to their children.

Science Mom

You mean all twenty or so of them? I think third world dictators speeches attract orders of magnitude more.

Dyson

True, it was a rally, of sorts.
Videos show Moms trying to tell stories on the mike, while disinterested passers-by wander aimlessly around (or not so aimlessly - some went up to a table to pick up copies of some book (Probably "Callous Disregard", hundreds of copies of which remain unsold from the print run).
Around 50-60 people, tops.

Mofmars333

The witch hunt against Wakefield was obvious to those paying attention & now it is time for the real truth to come out in the wash.

ASD Researcher

The Question of Research.

The allegation was that these children were research lab rats * (Research project – Project 172-96) ... it's a point that's stuck in the public's mind. Is it so ?

This is what the UK High Court stated ...

"At the heart of the GMC's case against Professor Walker-Smith were two simple propositions: the investigations undertaken under his authority on eleven of the twelve Lancet children were done as part of a research project – Project 172-96 –
which required, but did not have, Ethics Committee approval; and they were clinically inappropriate."

What did Justice Mitting conclude ...

"For the reasons given above, both on general issues and the Lancet paper and in relation to individual children, the panel's overall conclusion that Professor Walker-Smith was guilty of serious professional misconduct was flawed, in two respects: inadequate and superficial reasoning and, in a number of instances, a wrong conclusion."

As I have explained, the medical records provide an equivocal answer to most of the questions which the panel had to decide. The panel had no alternative but to decide whether Professor Walker-Smith had told the truth to it and to his colleagues, contemporaneously.

"The GMC's approach to the fundamental issues in the case led it to believe that that was not necessary – an error from which many of the subsequent weaknesses in the panel's determination flowed. It had to decide what Professor Walker-Smith thought he was doing: if he believed he was undertaking research in the guise of clinical investigation and treatment, he deserved the finding that he had been guilty of serious professional misconduct and the sanction of erasure; if not, he did not, unless, perhaps, his actions fell outside the spectrum of that which would have been considered reasonable medical practice by an academic clinician. Its failure to address and decide that question is an error which goes to the root of its determination.

The panel's determination cannot stand. I therefore quash it. Miss Glynn, on the basis of sensible instructions, does not invite me to remit it to a fresh Fitness to Practice panel for redetermination. The end result is that the finding of serious professional misconduct and the sanction of erasure are both quashed.

* Hyperbole - exaggeration used for effect.

Dyson

Thanks for confirming what we have been saying - that Justice Mitting merely had to determine that on balance Walker Smith believed the tests he was doing in a number of cases were not research but deemed clinically appropriate. Walker Smith persuaded Mitting this was so.

However, that provides Wakefield with a huge problem - it doesn't get over the fact that the research did not have ethical approval, and that in some instances the tests were not clinically appropriate. Even Walker Smith determined that Child 12 should not be investigated, but Wakers went ahead and did it anyway, without ethical approval, and in contravention of his honorary contract with the hospital which stipulated he should not determine clinical matters for patients.

Whichever way you look at it, Walker Smith tipped Wakers into the garbage truck.

No wonder Wakefield could not appeal.

ASD Researcher

I suppose any reader can see how I outline a clear and coherent argument , evidenced by the UK High and your rather 'surly' reply.

In regards to Child 12 perhaps you can outline some sort of argument. Here's some questions to start ..

Which senior physician / medical officer undertook the LP ?

Which senior physician / medical officer undertook the LP ?

Which senior nurse signed off on the procedures ?

Did any parent complain to the GMC in regards to those procedures ?

Can you show me anywhere in the GMC transcripts where the board interviewed any of the key hospital personnel to make a clear determination on that matter ?

------------------------------------

What does Justice Mitting say ...

"Despite Professor Walker-Smith's direction that no MRI scan or lumbar puncture should be performed, both were performed on 9th January 1997. The clinical notes contain no explanation for this change and none of the clinicians who gave evidence were able to remember or explain the reason.

Simple clerical error would certainly be the most reasonable explanation.

But 'conspiracy theory ' reads better.

Dyson

"Medical negligence", gross professional misconduct and unspeakable incompetence are the phrases that spring to everyone else's mind.

Presumably you are happy to dismiss these atrocities with a wave of the hand and deference to "must have been a clerical error... no harm done I hope"?

Hardly inspiring confidence in your rigorous examination of medical practise.

Science Mom

""Yes but the Lancet paper was predicated upon the receipt of MMR*...""

"You could argue that, but as the children were referred to a tertiary gastroenterology unit for clinical work up the more likely predication would be severe GI disease. That was evidenced by Justice Mitting and in the Lancet paper title itself.

Also it would be difficult to find a group of children without MMR at that time. There were in existence mass vaccinations of children.

*There were also one child who received monovalent measles immunisation"

JRS, you continue to obfuscate and try to distract. But you ignore the fact that most of the Lancet children had been pre-assembled by Richard Barr and handed over to Wakefield to find some damning evidence that MMR caused autism. They were not referred to Royal Free in the consecutive fashion that Wakefield claimed and found proved guilty of.

Wakefield claimed the measles portion of the triple jab continued to replicate, cause "leaky gut", proteins including measles vaccine virus then zoomed to the brain to cause autism (keeping it simple for the "evidence-based science" crowd). Except that no replicating measles vaccine virus was actually found, no leaky gut and no evidence of "vaccine-induced autism". There was no "severe GI disease". The only commonality between the Lancet children and current research findings is that they have intestines. The Lancet results are not reproducible insofar as the histopathology and you have Wakefield to thank for that. Please stop smearing good scientists with your obsession to prove Wakefield was "on to something" because even those investigators want nothing to do with Wakefield.

Dyson

You have it wrong SciMom.

You see, the fact that autistic kids get bowel issues is proof that Wakefield was right, because he said they got a different type of bowel issue too. So absolutely everything he says is gospel true, like absolutely 4eva.

And if I Wakefield says that a plane runs on liquid aerofuel that is a mixture of 1 part peacock feathers, 1 part sunshine and 2 parts titanium white paint, then the fact that other people say planes run on aviation fuel is proof he is right.

Science Mom

I do like that analogy Dyson, very apt. But I fear for you that you would be able to negotiate their mental gymnastics so adroitly. :D

ASD Researcher

It would be a with a touch of irony then that I present former BMJ 'star witness'.

Intestinal permeability: an overview.
Bjarnason I, MacPherson A, Hollander D.
Source

Department of Clinical Biochemistry, King's College School of Medicine, London, England.

Abstract

The noninvasive assessment of intestinal permeability in humans has a 20-year history.

Because the tests are increasingly used in clinical practice and research and because there is much controversy, we reviewed the literature and outlined the potential and possible shortcomings of these procedures. Data was obtained from personal files and from a systemic search through MEDLINE and EMBASE. The principle of the differential urinary excretion of orally administered test markers is explained with reference to the desired physicochemical properties of the markers and how the principle can be exploited to allow assessment of various other gastrointestinal functions. The use of intestinal permeability tests for diagnostic screen for small bowel disease and assessment of responses to treatment, the pathogenesis of disease, normal intestinal physiology, and the effect of drugs and toxins on the intestine is described and reviewed.

The controversy surrounding the anatomic location of the permeation pathways that the markers use is highlighted. Noninvasive tests of intestinal permeability have fulfilled early promises of usefulness in clinical practice and research. There is now a need for integrated research into the basic mechanisms of regulatory control of the intestinal barrier function.

Of course he later appeared as star witness ...

"he says that the forms don't clearly support charges that Wakefield deliberately misinterpreted the records. "The data are subjective. It's different to say it's deliberate falsification," he says."

hmmm ... Professor of Pathology and Professor of Paediatric Gastroenetrology actually saw all the material in regards to the children's bowel diseases.

That's what professional clinicians do ... and that's why the good Professor Bjarnason was a bit "wishy washy" *

As a Professor in Gastroenterology he knows Intestinal permiability is a real physiological condition as we all do. As is colitis , as are the Inflammatory Bowel Disease in autistic children.

I'm surprised anyone would argue against it.

* Hyperbole

Dyson

I rest my case.

According to this individual ("ASD researcher", who is someone called John Richard Smith, and NOT an autism researcher at all), the fact that autistics can have bowel issues is proof Wakefield was right.
He hasn't a clue.

Dyson

Another analogy would be:
Claiming a Black & Decker power tool is the same as a slinky little black skirt, because they both use the same color word in their description.

ASD Researcher

Although I'm primarily concerned with the allegations that were made against John Walker-Smith and that were subsequently quashed by the High Court it is obvious that the misinformation about this case is still being disseminated.

1. "But you ignore the fact that most of the Lancet children had been pre-assembled by Richard Barr"

Setting aside your hyperbolic language the argument you make relies on a vast collection of parents , children , solicitors , lawyers and QC's being involved in a vast conspiracy to ... get their children's severe bowel disorders treated

2. Not all the parents were of the same opinion as to a role of MMR, nor for that matter the clinicians. That's a large hole in the conspiracy theory

3. Critics such as yourself have never been able to point out specifically which parents had entered into formal litigation proceedings ie by court writ lodged at the UK high Court. That is a curious large hole in the conspiracy theory.

"handed over to Wakefield to find some damning evidence that MMR"

1. Andy Wakefield was employed as an objective expert witness and that all his work and opinion about it would be judged in the UK high Court.

Coincidentally the same High Court that exonerated Professor John Walker-Smith

2. Richard Barr and Andy Wakefield had approached both the Her Majesty's government and her opposition. They were rebuffed by the government

3. Most importantly you forget that evidence was actually present in the clinical notes taken and the medical records. That evidence was never tested in court.

----------------------------------------------------------

They were not referred to Royal Free in the consecutive fashion that Wakefield claimed and found proved guilty of.

The UK High Court Judgement

"We describe a pattern of colitis and ileal-lymphoid-nodular hyperplasia in children with developmental disorders. Intestinal and behavioural pathologies may have occurred together by chance, reflecting a selection bias in a self-referred group; however the uniformity of the intestinal pathological changes and the fact that previous studies have found intestinal dysfunction in children with autistic-spectrum disorders, suggests that the connection is real and reflects a unique disease process."

Justice Mitting

The statement made by the panel in paragraph 32c that it was Professor Walker-Smith who had described the referral process in the Lancet paper as "routine" was wrong.

It put its stretched meaning of the wording of part of the paper into his mouth and then found that it was irresponsible and misleading.

This was not a legitimate finding.

The findings in paragraphs 32a that the referrals of four children were not routine because the referring doctors did not mention intestinal symptoms in their referral letters was factually accurate as to the contents of the referral letters, but of no significance.

In each case, Professor Walker-Smith elicited gastrointestinal symptoms at his outpatients clinic. The finding at paragraph 32a that all four children "lacked a history of gastrointestinal symptoms" is wrong unless the panel intended only to refer to the contents of the referral letters.

The finding in paragraph 32b(ii) was correct, but, on its own, of little significance. (The genesis of the referral is explained in paragraphs 81 and 82 of this judgment).

The panel's finding that the description of the patient population in the Lancet paper was misleading would only have been justified if its primary finding that all of the Lancet children were referred for the purposes of research as part of Project 172-96 is sustainable. Because, for the reasons which I have given, it was not, this aspect of its findings must also fall.

Science Mom

"Setting aside your hyperbolic language the argument you make relies on a vast collection of parents , children , solicitors , lawyers and QC's being involved in a vast conspiracy to ... get their children's severe bowel disorders treated"

Hyperbolic language really? No, the so-called conspiracy wasn't that deep. And the children's bowel disorders were so severe that they had to stop at the lawyer's office before getting their children seen? Dr. Walker-Smith's reputation was surely known and yet none of them sought him out before Richard Barr and Wakefield. Dr. Walker-Smith had no idea that Wakefield had previous contact with these ten children and their parents when they arrived at Royal Free.

2. Not all the parents were of the same opinion as to a role of MMR, nor for that matter the clinicians. That's a large hole in the conspiracy theory

Nah, only ten of them did, their lawyer and Wakefield. What's your point and how is that "a large hole in the conspiracy theory"? By the way, the relationship is well-documented it isn't a conspiracy theory.

3. Critics such as yourself have never been able to point out specifically which parents had entered into formal litigation proceedings ie by court writ lodged at the UK high Court. That is a curious large hole in the conspiracy theory.

Oh I see so because I don't name names of children whose records I don't have access to, it's just some big black hole? Really Smith? And you don't think that this is also well documented by say the UK court and GMC just to name a couple? Honestly, you might be a little more articulate than these other goofball Wakefield apologists here but you don't have any more sense.

As to the rest of your mental meandering, the Barr-Wakefield relationship is well-documented in the GMC transcripts and most of the parents sought legal aid well before they specialised medical consultation at Royal Free. Now I know that Walker-Smith and Wakefield both begin with Wa-, have an l, i, e and k in there but they are two entirely different people. You keep using Walker-Smith's appeal as though it is for Wakefield too. It isn't. Justice Miting's decision was for Walker-Smith's role in the Lancet nonsense, not Wakefield. Walker-Smith, along with the other co-authors knew nothing about Wakefield's arrangement with Barr nor that most of the children that came to RF were pre-arranged. No conspiracy theory, just a greedy, grasping, unethical physician, a dubious lawyer and easily-manipulated parents.

ASD Researcher

"Hyperbolic language really?"

Yes ... a deliberate exaggeration used for effect.

" And the children's bowel disorders were so severe that they had to stop at the lawyer's office before getting their children seen?"

If you think slurs against parents of children with severe autism and severe bowel disease makes your case stronger then you will not find any sympathy here.

Dr. Walker-Smith's reputation was surely known and yet none of them sought him out before

Professor Walker-Smith

If you read the documentation in the GMC and the UK High Court quashing you will see only too clearly what steps were taken to ensure the proper medical treatment for these children. If you are unfamiliar with how you proceed to a tertiary medical facility under the UK medical system I'm sure I can help you out ... but to briefly state, you just can't knock on his door .

Dr. Walker-Smith had no idea that Wakefield had previous contact with these ten children and their parents when they arrived at Royal Free.

Professor Walker-Smith. Of insignificance Walker-Smith completed his clinical duties professionally and honestly.

The accusation was that he had not ... it was quashed.

It reinforces again that the children were examined for their severe bowel diseases / disorders

You have also not shown that the parents had launched any litigation via UK High Court writ or that there intention was something other than the full clinical work up and treatment of their children's bowel diseases , whatever the cause or pathology

----------------------------------------------------

" Nah, only ten of them did, their lawyer and Wakefield. "

If that is your opinion please provide the evidence that supports that. Even if they had an opinion on the causation ... they sent their children to a Paediatric Gastroenterologist Unit not a virologist.

That's another hole you are going to fill in your narrative.

-------------------------

By the way, the relationship is well-documented it isn't a conspiracy theory.

Of course it isn't. It is the legitimate and judicial way in which these matters are settled. The public are entitled to access the law to have disputes surrounding medical matters settled.

---------------------------

Oh I see so because I don't name names of children whose records I don't have access to, it's just some big black hole?

Yes

And you don't think that this is also well documented by say the UK court and GMC just to name a couple?

Put it on the table.

--------------------------------------

the Barr-Wakefield relationship is well-documented in the GMC transcripts

Of course it is - he was contracted to carry out a number of research tasks to define whether there was a case to be dealt with at a judicial level acting as an expert witness.

That's what people do in medical litigation.

Here's some legal commentary published in the BMJ

"I do not know how ******* thinks that solicitors who are acting for more than one client with a common complaint should obtain medical evidence. The parents had not gone to the Royal Free 'precisely to blame MMR, wanting (an expert) to help their children and their claims'. Like most clients, they had a theory about how their child's condition had been adversely affected and so they went to an independent expert in an appropriate field seeking an objective assessment to see if there was a link, because they all felt that the changes in their children's behavioural changes were associated in time with the MMR vaccination. "

"Again, as I understand it, Dr Wakefield was quite genuinely concerned by his findings and thought they should be urgently flagged up for wider investigation. I cannot see that this stance was anything more than the natural reaction of any concerned clinician who thought there might be a link.

Justice Mitting's decision was for Walker-Smith's role in the Lancet nonsense, not Wakefield.

Then I might think you haven't read the Justice Mittings findings with a critical reflection on what they might mean to Andy Wakefield's case.

... just a greedy, grasping, unethical physician, a dubious lawyer and easily-manipulated parents.

That's what some would like the narrative to portray but it's a lot more complicated than that.

lilady

I'm just loving all these verbose nonsensical spamming comments.

Make certain you put the video of Andy's "press conference" up on all your media outlets websites. We could use some laughs.

ASD Researcher

Autism Research where are we headed ?

"The money that the Federal government can devote to research through the NIH is finite. The IACC (Interagency Autism Coordinating Council) is dedicated to bringing all stakeholders together including governmental agencies, private foundations, parents of autistic children and those who have an autism diagnosis, to coordinate programs and research projects to investigate the antenatal causes of autism and to research viable treatments to help autistic youngsters and adults to reach their highest potential."

Those of us working actively in the autistic community in research and other roles understand the significance of much of the recent surrounding autism.

1. Genetic studies remain important but our understanding of a 'single gene' interaction has changed significantly over the past two years. Professor Sir Michael Rutter admitted to a European conference that this likelihood of direct gene effect has come to some stagnancy with around 10 - 15 % of autism linked with CNV's etc.

Focus is now being turned to the interactions of hundreds of genes and gene networks significantly one involves neurology the other the immune system.

Transcriptomic analysis of autistic brain reveals convergent molecular pathology

http://www.ncbi.nlm.nih.gov/pubmed/21614001

Using high-throughput RNA sequencing we demonstrate dysregulated splicing of A2BP1-dependent alternative exons in the ASD brain. Moreover, using a published autism genome-wide association study (GWAS) data set, we show that the neuronal module is enriched for genetically associated variants, providing independent support for the causal involvement of these genes in autism.

In contrast, the immune-glial module showed no enrichment for autism GWAS signals, indicating a non-genetic aetiology for this process. Collectively, our results provide strong evidence for convergent molecular abnormalities in ASD, and implicate transcriptional and splicing dysregulation as underlying mechanisms of neuronal dysfunction in this disorder.

What does that mean in plain english ...

In that paper, Dan found that the specially expressed genes in autism fell into two groups, one having to do with synapses and neuronal function, and the second having to do with glia and immune function. This place immune function once more at the heart of autism gene network activity.

Aberrant NF-KappaB Expression in Autism Spectrum Condition: A Mechanism for Neuroinflammation

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3098713/

Autism spectrum condition (ASC) is recognized as having an inflammatory component.

Post-mortem brain samples from patients with ASC display neuroglial activation and inflammatory markers in cerebrospinal fluid, although little is known about the underlying molecular mechanisms.

In summary, NF-κB is aberrantly expressed in orbitofrontal cortex in patients with ASC , as part of a putative molecular cascade leading to inflammation, especially of resident immune cells in brain regions associated with the behavioral and clinical symptoms of ASC.

* Autism spectrum condition (ASC)

Expression Profiling of Autism Candidate Genes during Human Brain Development Implicates Central Immune Signaling Pathways

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0024691

We hypothesized that focusing gene interaction networks on ASD-implicated genes that are highly expressed in the developing brain may reveal core mechanisms that are otherwise obscured by the genomic heterogeneity of the disorder.

Strikingly, immune signaling through NFκB, Tnf, and Jnk was central to ASD networks at multiple levels of our analysis, and cell-type specific expression suggested glia—in addition to neurons—deserve consideration.

This work provides integrated genomic evidence that ASD-implicated genes may converge on central cytokine signaling pathways.

----------------------------------------------

Discussion

Interestingly, there is also mounting evidence at the cellular and tissue levels that more in depth investigation of an immune component is warranted in ASD

For instance, multiple studies have demonstrated altered cytokine profiles in ASD patients and altered TGF-B concentration in serum and CSF correlates with disease severity

Others have described various autoimmune phenomena including autoantibodies to neural antigens and maternal-fetal cross-reactive neural antibodies.

There is also indication of altered innate cellular immunity in ASD , such as differences in gene expression and altered response to immunostimlulatory ligands in both natural killer and monocytic cells from ASD patients.

Post-mortem brain tissue from ASD patients shows increased microglial density in grey matter, an activated morphology, and secretion of a cytokine profile consistent with a pro-inflammatory state, most prominent in the cerebellum

Moreover, microglia from MeCP2- null mice—a model of the Autism Spectrum Disorder Rett Syndrome—produce a conditioned media that damages synaptic connectivity via a glutamate-excitotoxicity mechanism.

While all of this work provides post-hoc evidence for altered immune response in ASD, our results suggest a direct link between implicated genes in ASD and molecular pathways involved in immune signaling.

This considerable attention to the immune response in previous ASD research has resulted in two prevailing theories: one suggests exogenous factor(s) stimulate neuro-inflammation during development, while the other postulates autoimmune activation causes ASD pathology

However, it is equally possible—as our results support—that the mutations described in ASD result in aberrant signaling regulation of immune cells during neurodevelopment. This could result in cell-autonomous activation and/or improper response to otherwise nominal stimuli, such as occurs in the autoinflammatory syndromes

Jenny Allan

Thank you ASD researcher. I found your comments interesting and refreshingly free from ad hominem and other denigrating comments concerning other posters evidence and points of view. The following is an excerpt from the 1998 Wakefield et al paper which caused all the controversy. I think this shows very clearly that scientific evidence and opinions have now gone full circle:-
"Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children
Volume 351, Number 9103 28 February 1998 A J Wakefield, S H Murch, A Anthony, J Linnell, D M Casson, M Malik, M Berelowitz, A P Dhillon, M A Thomson, P Harvey, A Valentine, S E Davies, J A Walker-Smith
A genetic predisposition to autistic-spectrum disorders is suggested by over-representation in boys and a greater concordance rate in monozygotic than in dizygotic twins.15 In the context of susceptibility to infection, a genetic
association with autism, linked to a null allele of the complement (C) 4B gene located in the class III region of the major-histocompatibility complex, has been recorded by Warren and colleagues.24 C4B-gene products are crucial for the activation of the complement pathway and protection against infection: individuals inheriting one or two C4B null alleles may not handle certain viruses appropriately, possibly including attenuated strains"

ASD Researcher

Hi Jenny

Thanks for your kind words.

If more people are able to set aside the vaccine issue and look at other aspects of the Lancet paper they will see how valuable it is to the autism and disabilities communities, children , parents and carers.

We are on the verge on some exciting breakthroughs in treatment and care for a significant number of ASD children.

We all have differing views and are trying to address many issues that this one paper generated. As to the piece you refer only recently Leigh Needleman and Kimberley McCallister published this paper ...

The major histocompatibility complex and autism spectrum disorder.

http://www.ncbi.nlm.nih.gov/pubmed/22760919

Autism spectrum disorder (ASD) is a complex disorder that appears to be caused by interactions between genetic changes and environmental insults during early development.

A wide range of factors have been linked to the onset of ASD, but recently both genetic associations and environmental factors point to a central role for immune-related genes and immune responses to environmental stimuli.

Specifically, many of the proteins encoded by the major histocompatibility complex (MHC) play a vital role in the formation, refinement, maintenance, and plasticity of the brain.

Manipulations of levels of MHC molecules have illustrated how disrupted MHC signaling can significantly alter brain connectivity and function.

Thus, an emerging hypothesis in our field is that disruptions in MHC expression in the developing brain caused by mutations and/or immune dysregulation may contribute to the altered brain connectivity and function characteristic of ASD. This review provides an overview of the structure and function of the three classes of MHC molecules in the immune system, healthy brain, and their possible involvement in ASD

One of the most obvious relationships is ... autoimmune diseases.

Defining the Role of the MHC in Autoimmunity: A Review and Pooled Analysis

http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1000024

The major histocompatibility complex (MHC) is one of the most extensively studied regions in the human genome because of the association of variants at this locus with autoimmune, infectious, and inflammatory diseases.

However, identification of causal variants within the MHC for the majority of these diseases has remained difficult due to the great variability and extensive linkage disequilibrium (LD) that exists among alleles throughout this locus, coupled with inadequate study design whereby only a limited subset of about 20 from a total of approximately 250 genes have been studied in small cohorts of predominantly European origin.

We have performed a review and pooled analysis of the past 30 years of research on the role of the MHC in six genetically complex disease traits – multiple sclerosis (MS), type 1 diabetes (T1D), systemic lupus erythematosus (SLE), ulcerative colitis (UC), Crohn's disease (CD), and rheumatoid arthritis (RA)
– in order to consolidate and evaluate the current literature regarding MHC genetics in these common autoimmune and inflammatory diseases.

We corroborate established MHC disease associations and identify predisposing variants that previously have not been appreciated. Furthermore, we find a number of interesting commonalities and differences across diseases that implicate both general and disease-specific pathogenetic mechanisms in autoimmunity.

Science is such a wonderful thing and is constantly amazing us with it's complexity and it's interactions. We should all embrace science.

Science Mom

"If more people are able to set aside the vaccine issue and look at other aspects of the Lancet paper they will see how valuable it is to the autism and disabilities communities, children , parents and carers."

Yes but the Lancet paper was predicated upon the receipt of MMR and even though Wakefield took the PCR results out of this one, he merely published that along with more erroneous PCR results in other studies. His findings do not reflect the work that is being done now.

ASD Researcher

Science Mom

"Yes but the Lancet paper was predicated upon the receipt of MMR*..."

You could argue that, but as the children were referred to a tertiary gastroenterology unit for clinical work up the more likely predication would be severe GI disease. That was evidenced by Justice Mitting and in the Lancet paper title itself.

Also it would be difficult to find a group of children without MMR at that time. There were in existence mass vaccinations of children.

*There were also one child who received monovalent measles immunisation

lilady

The subject of this blog is the fact that investigative journalist Brian Deer was invited to UW-Lacrosse to discuss his investigation of Andrew Wakefield.

Mr. Wakefield's contacts at the Age of Autism, quickly arranged to rent a golf shed near the University for Mr. Wakefield to hold another of his tawdry cheap publicity "press conferences". Presumably "Team Wakefield" at the Age of Autism notified local media outlets about this impromptu "press conference" and we have this headline "Vaccine-Autism Debate Coming to La Crosse".

There is no debate about the subject of vaccines causing autism. The "debate" exists only in the minds of the notorious anti-vaccine organization here and in the U.K., in the minds of conspiracy theorists and in the minds of credulous parents who refuse to believe
that their child's autism was present in utero and present at birth.

We have wasted precious time and resources on studies conducted in the United States, in the U.K. and throughout the world that attempted, unsuccessfully, to replicate Wakefield fraudulent research results.

The money that the Federal government can devote to research through the NIH is finite. The IACC (Interagency Autism Coordinating Council) is dedicated to bringing all stakeholders together including governmental agencies, private foundations, parents of autistic children and those who have an autism diagnosis, to coordinate programs and research projects to investigate the antenatal causes of autism and to research viable treatments to help autistic youngsters and adults to reach their highest potential.

Wakefield's case is closed. He is a disgraced former doctor who lost his license to practice in the U.K. He had the opportunity to appeal the GMC decision and he didn't. He commenced a defamation suit against Mr. Deer in the U.K., then pleaded with the court to allow him to discontinue the lawsuit. The court in the U.K. ordered Wakefield to pay all of Mr. Deer's legal costs.

Here again, is the link to the GMC Fitness to Practice Hearing determination regarding Andrew Wakefield, which resulted in the revocation of his medical license. It is not "debatable":

http://www.gmc-uk.org/Wakefield_SPM_and_SANCTION.pdf_32595267.pdf

Twyla

There is a debate. So far on this blog 317 comments debating the subject of vaccines causing autism. And lots of debate elsewhere, too.

lilady

No Twyla...that "debate", if there ever was one, ended years ago. Evidence-based science has prevailed. Time for you and your band of anti-vaccination bloggers and cranks to move on...and take Wakefield with you.

lookinglass

No Lilady...that"debate" if there ever was one, ended years ago. Evidence-based science has prevailed. Time for you and your band of pro-vaccination bloggers and cranks to move on...and take Deer with you.

lookinglass

Twyla when I said there was "no debate" in my post hours ago, I meant that there was, and never will be,any possibility of debate in its best and truest form with this lot of pro Deer accolytes . These automatons are not scientists, they are seek and destroy missiles. with a penchant for using sarcasm and abuse when they start feeling insecure, which is what bullying children do in a kids playground. They think it's clever. A lot of the adolescent criticism and rubbish that they throw at us can so easily and legitimately be thrown back at them. Honi soit qui mal y pense? But we don't. Except I did just now, to that sad little Lilady in order to prove the point, but she won't get it. They actually imagine we have a highly oranised attack team, like some sort of elite band of SAS with a base camp at AOA. Hilarious.
So....no debate then. But some good constructive information coming from ASD and yourself. Thankyou both.

Science Mom

"Evidence-based science has prevailed."

And what is this pray tell?

whiteandnerdy

Twyla,

Sure there are still debates.

Like how many anti-vaccs will end up convicted felons?

And why do some parents not care about the anti-vacc fraud?

W&N

whiteandnerdy

Twyla,

Sure there are still debates.

Like how many anti-vaccs will end up convicted felons?

And why do some parents not care about the anti-vacc fraud?

W&N

whiteandnerdy

Lookingglass,

We can't all be scientists, but we are all functionally literate....

We can all read the Lancet paper and see how Wakefield lied about his funding.

We can all read the Omnibus transcripts and see how families were lied to with false testing results, etc, etc.

But you are right, there is no debate....there is no possible rational conversation... with a person that cares so little for our children that they won't even read the words.

W&N

AutismNewsBeat

Flat Earth Debate Coming to LaCrosse!

ASD Researcher

The BMJ interpretation is not supported.

It now seems likely that the BMJ were premature in their diagnosis and interpretation of what is quite complex interactions between physiology and neurology in those children.

For those who are unfamiliar Professor John Walker-Smith and his team of paediatric gastroenterologists were clinicians at one the UK's most prestigious teaching hospitals the Royal Free. (Now University College London)

When they physically examined the children , interviewed the parents for patient history and undertook varying medical examinations including EEG's, colonoscopies and LP's they concluded that there was an association between the childrens behaviour and their guts.

Particularly significant was the findings by the team including Professor Amar Dhillon pathologist of inflammation in the small intestine and other regions of the gastrointestinal tract.

What they witnessed was children apparently developing normally , then regressing ie losing skills , behaviours and speech, this coincided with the GI conditions.

They noted as GI conditions worsened so did regression , as GI conditions were treated GII conditions improved but so did the child's Autistic Behaviours as well as speech , language and communication.

That simple link between autism, GI disease has been proven quite simply not only by the scientific evidence but by any any parent with a very sick child. In sections of medical science it's called 'sickness behaviour'.

What was noted was that these children were not just suffering the day to day GI symptoms that 'normal' children, have they showed on expert examination by professors in paediatric gastroenterology and pathology the signs of inflammation - Colitis.

Not just one person looked at all the pathology material and undertook the colonoscopies this was a team of very professional , honest , skilled and eminent medical officers.

Three important findings -

the children had autism

the children regressed ie their behaviour , speech communication worsened.

the children had signs of inflammation or significant bowel disorder

------------------------------------------------------

If the interpretation of the BMJ is correct in the scientific evidence there should not be any evidence that any of these three factors are present.

The evidence speaks against the BMJ interpretation

1. The specific children were diagnosed in the Autistic Spectrum Disorder (ASD) range.

This is evidenced in the findings of Justice Mitting here

http://www.bailii.org/ew/cases/EWHC/Admin/2012/503.html

2. Regression in ASD and GI is evidenced as above by Justice Mitting and also in the scientific literature for example -

Impaired Carbohydrate Digestion and Transport and Mucosal Dysbiosis in the Intestines of Children with Autism and Gastrointestinal Disturbances

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174969/

"Regression (loss of language and/or other skills following acquisition) is reported in 20% to 40% of individuals with autism, and some studies suggest higher rates of GI symptoms in ASD subjects with regression than those without regression [27]. Eighty-seven percent of AUT-GI subjects in our study had behavioral regression"

It is well worth reading that again because this was the second study that found an almost identical per centage (88%)

Eighty-seven percent of AUT-GI subjects in our study had behavioral regression


3. the children had signs of inflammation or significant bowel disorder

This evidenced first by balancing that the work and pathology was undertaken by a team of tertiary medical professionals. To which one of their jobs was to train other doctors to the highest levels of skill in their fields.

Secondly they had between them a vast number of years of experience particularly in examination of children and GI disorders.

Thirdly they were the ones that actually saw the patients themselves , their physical symptomatology , their small intestines through colonoscopy and the pathology that was taken.

Most notably systemic inflammation in not only the gut but the brain is a fully recognised and important feature of Autistic Spectrum Disorders.

Not only is it described in cohorts of childrens as found in this study by Harvard researchers ...

The Co-Morbidity Burden of Children and Young Adults with Autism Spectrum Disorders

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0033224

They significantly found and this is a reminder that these finding do not apply to all ASD children ...

19.44% of ASD patients had epilepsy as compared to 2.19% in the overall hospital population

2.43% of ASD with schizophrenia vs. 0.24% in the hospital population

inflammatory bowel disease (IBD) 0.83% vs. 0.54%

bowel disorders (without IBD) 11.74% vs. 4.5%

CNS/cranial anomalies 12.45% vs. 1.19%

diabetes mellitus type I (DM1) 0.79% vs. 0.34%

muscular dystrophy 0.47% vs 0.05%

sleep disorders 1.12% vs. 0.14%

Autoimmune disorders (excluding DM1 and IBD) were not significantly different at 0.67% vs. 0.68%

------------------------

They also found as the child grew older into adulthood Inflammatory Bowel Disease became more common... worryingly so did Schizophrenia (linked to inflammatory conditions in the brain)

Three of the studied comorbidities increased significantly when comparing ages 0–17 vs 18–34

Schizophrenia (1.43% vs. 8.76%),

diabetes mellitus type I (0.67% vs. 2.08%)

IBD (0.68% vs. 1.99%)

whereas sleeping disorders, bowel disorders (without IBD) and epilepsy did not change significantly.

-------------------------------------------------------

If the BMJ interpretation is correct we should not see the types of inflammatory disorders evident in ASD children , unfortunately we do.These are very sick children.

IBD is an inflammatory disease

Schizophrenia is strongly linked to inflammation

Diabetes (http://www.sciencedaily.com/releases/2007/11/071106133106.htm)

Muscular Dystrophy - (http://www.sciencedaily.com/releases/2010/05/100526103801.htm)

-------------------------------------------------------

Simply all the evidence speaks specifically on the issue of Autism , GI and Inflammation to those published by John Walker-Smith in the Lancet paper

None speaks to the BMJ.

----------------------------------------------

Addendum

Even the genetics speak loudly to the John Walker-Smith interpretation ...

Regional susceptibility to TNF-α induction of murine brain inflammation via classical IKK/NF-κB signalling.

It is becoming clear that inflammation plays a significant role in a number of neurological and psychiatric conditions. Post mortem brain samples in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis, schizophrenia and most recently autism spectrum condition, all exhibit neuroglial activation and inflammatory markers within the CSF.

There's a lot more evidence, but what is most important that the science and medical care of very sick children is not steam rolled by people trying to prove another agenda.

People need to look and set aside the vaccine issue - the outcomes for these children that have autism is poor. Recent research shows they are 9x more likely to die prematurely.

4x more likely to suffer Schizophrenia.

Rates of anxiety and depression are much much larger than the general population. Inflammation is a factor in some GI and Inflammatory Bowel Diseases are , there is a complex and as yet fully elucidated interaction between many factors , environment , physiology , neurology ... setting aside our prejudices will benefit all.

Talk to you paediatricians , talk about GI and inflammation or immune system dysfunction ...

Continue to vaccinate your children as I have done with my family but if you have specific worries talk to professional medical officers. Access those people that work specifically with Autistic children for instance - University of California Davis MIND Institute.

http://www.ucdmc.ucdavis.edu/mindinstitute/

All the best to the autism and disabilities communities. Listen , think, be critical.


ASD Researcher

In Reply to ndavis

I'm not sure your colleagues would ignore the clear scientific evidence and the professional diagnosis of medical officers at a tertiary teaching hospital.

Which one would they balance ? Professor John Walker-Smith or Dr Mark Berelowitz

Is Professor John Walker-Smith who took the records surrounding the gastrointestinal results and a Professor in Paediatric Gastroenterology likely to make errors of judgement or clinical practice ?

or Dr Mark Berelowitz Consultant Child and Adolescent Psychiatrist MB,BCh, MPhil, MRCPsych, FRCPsych (http://www.expertsearch.co.uk/cgi-bin/find_expert?1255 )

I think any medical or scientific professional in 2012 understands that there is a complex relationship between the gut, GI disease and ASD behaviour in those very special children.

Complex medical diagnosis of children cannot be made by either by journalists or doctors that have not witnessed or physically examined the patients. Or for that matter interviewed the patients before them. Or for that matter seen the varying pathology materials , blood tests , EEG's ...

-------------------------------

As to your statements made -

"Deer was discussing the particular children in the Lancet study rather than all children with ASD."

...and Mr Deer has no qualifications in medicine or has trained as a scientist, ironic isn't it. Nor has he medically examined the children or undertaken a medical diagnosis of the children.

"However, you elected to cast the argument as something like this..."

It's called evidenced based medicine. Comparing like populations ASD children with the same GI issues.

"therefore (3) Deer lied. That’s sad. "

Excuse me I never said Mr Deer lied quite the opposite. He's presented a case he carefully examined and put together over a number of years. But what he and the British Medical Journal did was not take into account was the scientific evidence surrounding regression in ASD GI patients.

Nor did they allow for physical medical diagnosis of the children or parental interviews that would have clarified and answered their own questions.

Nor has he had access to the range of physical evidence such as pathology , blood, urinary and other samples / slides.

More importantly they did not allow the very doctors that did examine the children at the time a chance to elucidate their diagnosis and findings.

People are able to make up their own minds on these questions of science and weigh up what evidence I have presented and the evidence that was presented in the BMJ.

I have an opinion that the BMJ case on this matter is particularly weak, the interpretation is weak , the diagnostic medical evidence is weak, the published research shows it to be weak ... you always have the opportunity as a scientist to show my interpretation is in error.

ndavis

That's just wacky talk.

"[W]hat [Deer] and the British Medical Journal did was not take into account was the scientific evidence surrounding regression in ASD GI patients."

You have again conflated the evidence from 11 individual patients with the broader population, including those examined at a later date and according to differing criteria. That's nonsensical--as you should know.

You wrote: "People are able to make up their own minds on these questions of science and weigh up what evidence I have presented and the evidence that was presented in the BMJ." That's true--but, unfortunately, most people have no more training or expertise in these areas than you have, so they are no more likely than you are to be able to understand these issues--and you have shown that you are not an "ASD researcher" in any sense of the term except that of "someone with an internet connection."

Yellowriver

http://www.ageofautism.com/2012/10/researcher-wakefield-in-lacrosse-oct-4-to-detail-uk-reporters-fraud.html

Science Mom

And the point of your pointless spam is Yellowriver? So Wakefield is giving a sad little "press conference" in a park shed because he is very very upset with Brian Deer who is presenting a "how to" in investigative journal at a University auditorium by invitation. The visual dichotomy is delicious.

lilady

Sheer unadulterated spamming from Yellowriver...who works for the Autism Media Channel which is thoroughly anti-vaccine.

ASD Researcher

"That's just wacky talk."

If you can't reply in a mature and balanced way then it says more about you then it does about me.

"You have again conflated the evidence from 11 individual patients with the broader population, including those examined at a later date and according to differing criteria. That's nonsensical--as you should know."

The Lancet study was indeed a small case study , but was also supported by an additional patient population numbering between some 60 - 100. The additional medical evidence found in those children through colonoscopy and pathology gave additional support to their additional findings.

"That's nonsensical--as you should know."

No that's the pragmatics of examining paediatric populations and rare diseases and conditions. That's science and the investigation of ASD aetiology and pathology is a continuing journey of scientific and medical exploration.

Anyone with experience in autism knows the difficulties we all face in researching this area.

"That's true--but, unfortunately, most people have no more training or expertise in these areas than you have, so they are no more likely than you are to be able to understand these issues"

I'll just point out that you have not shown any scientific evidence to the contrary.

That speaks louder than any assumptions or immature slurs on what my professional and personal qualifications are in this area.

Dyson

"The additional medical evidence found in those children through colonoscopy and pathology gave additional support to their additional findings."

So in which medical journal was that fraud published then?

Yellowriver

"The launch of Professor John Walker-Smith's book - "Enduring Memories" will be held on Saturday 6th October from 5 to 6pm at The Village Bookshop , 475 High Road Woodford Green as part of the Woodford Festival. Copies will be available for 6th October. A "MUST READ"!!!!"

lilady

Spamming for John Walker-Smith new book?

ASD Researcher

Would make excellent reading of a proud and honest man who has steered us on a the most exciting research in Autism.

Dyson

More like an aging icon who was duped by a younger colleague into taking part in fraudulent research.

whiteandnerdy

For lookingglass,

"There is only lies, lies and more lies from.." the anti-vaccs....but then running a healthcare scam does require lying to people.

Still sites like this are very helpful.

Anyone with an honest interest in our children can easily find the Lancet's information for Authors:
http://www.thelancet.com/lancet-information-for-authors

And read Wakefield's paper:
http://feingold.org/Research/PDFstudies/RETRACTED-Wakefield1998html.pdf

All it takes is the integrity to read the words to see that Wakefield lied.

Further, it is clear from the postings of the anti-vaccs like you, Twyla etc just don't care that he engaged in fraud.

Rather helpful for revealing the true nature of the anti-vaccs.

Thanks,
W&N

Science Mom

"Science Mom, Dr. Wakefield is not the basis of our unity or identity. He is just a brave, compassionate, highly intelligent, well educated doctor who researched his patients' health conditions and dared to not back down."

Oh he most certainly is or you wouldn't be performing the mental contortions worthy of a gold medal to keep him in the spotlight. He's using all of you by perpetuating the brave maverick doctor patina. He's lied, he's manufactured data, he ordered invasive, non-indicated testing on special needs children, he's used special needs children as guinea pigs for his goat nostrum, he's taken unauthorised blood samples from children and then made fun of them. And here the lot of you are defending this sleaze and speaks volumes as to your own scruples.

"The injustice done to him is terrible. He should be working and winning accolades and helping to make progress in treating serious GI issues."

The only injustice is that it took so long to get him away from children. The real and ethical physicians and scientists who seek proper approval and who seek appropriate and ethical funding and who perform robust studies and publish them are the ones making inroads to discovering autism aetiology and co-morbidities that may accompany autism. Those are the ones you should be celebrating, thanking and contributing to. Tell us Twyla, what has your de-licensed hero done for autists and what will he ever do?

"Science Mom, you think you can differentiate between the "truly vaccine-injured children" and the not truly vaccine-injured based on a parent's comments? That's not scientific at all."

Oh Twyla, the paragon of science and truth. Yea, it's not hard to elucidate the likely scenario of a child's so-called "vaccine injury" when parents vomit their children's medical histories all over the internet and/or become NVICP petitioners. Too bad these parents have no respect for their children's right to privacy but then again, they are the same ones who dehumanise their special needs children and treat them as gruesome science experiments.

lilady

@ Science Mom: I've asked Twyla, who is a "guest journalist" at Age of Autism to provide information about her own child. She claims her was "vaccine injured". She steadfastly refuses to answer my questions about her child..i.e., how old her child was when he was diagnosed with an ASD and when he was diagnosed with a genetic developmental syndrome.

whiteandnerdy

Credit where credit is due...Twyla keeps posting under the same handle.

Very useful since....to put it kindly....the gross, systematic errors in her sources have been pointed out many times.

Most people are willing to fact-check and find her behavior very helpful in understanding the anti-vacc fraud.

W&N

Yellowriver

"The launch of Professor John Waleker-Smith's book - "Enduring Memories" will be held on Saturday 6th October from 5 to 6pm at The Village Bookshop , 475 High Road Woodford Green as part of the Woodford Festival. Copies will be available for 6th October. A "MUST READ"!!!!"

Yellowriver

Sorry typo error should have been Prof John Walker-Smith's book

Twyla

Science Mom, your hostile rants are anything but scientific. All you do is throw slurs at everyone. It is very tiresome. Perhaps you should change your user name to something like, "Venemous Mudslinger", to be more accurate.

Science Mom

By whose directive am I to maintain some kind of script Twyla? I have provided numerous citations to relevant and original documentation unlike you who can only regurgitate AoA drek. Your moaning about my statements is positively outlandish considering your direct actions and the lovely people you are involved with who:
Threaten a sceptical blogger with rape with broken thermometer.
Consistently send and praise a boy to harass speakers at presentations.
Post photo-shopped pictures of your perceived enemies dining on a dead baby.
Disrupt national meetings with your wailing and gnashing of teeth because they have moved on and won't recommend funding for vaccinesdidit.
Harass your perceived enemies at their places of employment.
Threaten violence.
Write incessantly and fabricate 'evidence' that your perceived enemies are pharma shills.
Support horrible and abusive "treatments" for autistic children.

And that's just a short list of your so-called 'autism advocacy' Twyla. You don't get to claim any moral high ground here.

ASD Researcher

The British Medical Journal

Stated emphatically ...

"First to crack was “regressive autism,” the bedrock of his allegations.

Regression in autism has been investigated in many papers but of particular note is two papers undertaken by independent researchers and scientists that examined the same type of ASD children that Professor John Walker-Smith and Andrew Wakefield did, those with severe GI complaint. For instance as per Justice Mittings findings* in Walker-Smith's appeal.

*(I have dwelt at length upon the case of child 2, because it was the case upon which both sides placed greatest reliance.)

"Child 2 was born on 29th July 1988. MMR vaccine was given on 8th November 1989. Global developmental delay was first diagnosed in February 1991. Diarrhoea was first noted in the general practice records in January 1992. ,"Autistic-like regression" was first suggested in a joint report of April 1992 by Dr. Cass a Senior Paediatric Registrar and Miss Price a Speech Therapist at the Woolfson Centre."

Here's the independent research ... Columbia University 2008.

"Median AUT onset age was 13.5 (7.0) months (Table 2). Cases had a high rate of CPEA-defined behavioral regression (loss of language and/or other skills following acquisition), 88%, compared to published rates of 20–40% for the general ASD population"

in 2011 virtually the same authors from Columbia University undertook another comprehensive study. Once again examining ASD children with severe GI diseases / disorders.

"Regression (loss of language and/or other skills following acquisition) is reported in 20% to 40% of individuals with autism, and some studies suggest higher rates of GI symptoms in ASD subjects with regression than those without regression [27]. Eighty-seven percent of AUT-GI subjects in our study had behavioral regression "


Professor John Walker-Smith found 9 of 12 children exhibited regression, 75%

Columbia University 2008 found - 88% (actually more than Professor John Walker-Smith)

Columbia University 2011 found 87%

The BMJ in 2011 (supplementary data) confirmed only 1 / 12 = 8.3%

*Questioned marked 5 / 12 = 41.6%

Science is always complex and often produces more questions than answers.

That's why we sometimes need to defend innocence through the courts.

http://www.bailii.org/ew/cases/EWHC/Admin/2012/503.html

Professor John Walker-Smith

The panel's conclusion that Professor Walker-Smith's conduct was contrary to the clinical interests of child 2 depends upon the conclusions analysed above. Because they are inadequate or wrong, this conclusion falls with them.

-----------------------------------------------------

Footnote - Did treatment of bowel disorders reduce autistic behaviours ...

Dr Wozencroft Day 77 (General Medical Council)correspondence

“On 7th April I saw [Child 2] again with his mother. I observed a striking change in him.

Twice in the course of the interview, he made eye contact with me. As we walked down the corridor towards my office, his mum gave him a specific instruction about how he should walk. He changed his walk accordingly. In the course of the discussion, he made two verbal interventions which, on the face of it, appeared to be relevant to the matter his mother was discuss with me.

I had never seen [Child 2] responding in such an ordinary way. Something has made a significant difference to him since our last interview. Mother believes that it is the medical treatment he has been receiving from the Royal Free Hospital."

ASD Researcher

Did I forget to mention that Harvard researchers (2012) found that autistic children in hospital care had twice the rate of Inflammatory Bowel Disease and that when they grew the rate was three times.

They also found a lot more bowel disorders (without IBD) 11.74% vs. 4.5%.

Diseases with inflammatory components - schizophrenia , diabetes , muscular dystrophy...

These are very sick children. It is a reminder that if John Walker-Smith and Andrew Wakefield study and data was fraudulent why do we see the numbers of IBD , GI disorders , inflammatory diseases ...

Science Mom

Citation pretend ASD researcher?

lilady

Citationless Pretend ASD Researcher is cherry-picking and misinterpreting again:

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0033224

Abstract Top

Objectives

Use electronic health records Autism Spectrum Disorder (ASD) to assess the comorbidity burden of ASD in children and young adults.

Study Design

A retrospective prevalence study was performed using a distributed query system across three general hospitals and one pediatric hospital. Over 14,000 individuals under age 35 with ASD were characterized by their co-morbidities and conversely, the prevalence of ASD within these comorbidities was measured. The comorbidity prevalence of the younger (Age<18 years) and older (Age 18–34 years) individuals with ASD was compared.

Results

19.44% of ASD patients had epilepsy as compared to 2.19% in the overall hospital population (95% confidence interval for difference in percentages 13.58–14.69%), 2.43% of ASD with schizophrenia vs. 0.24% in the hospital population (95% CI 1.89–2.39%), inflammatory bowel disease (IBD) 0.83% vs. 0.54% (95% CI 0.13–0.43%), bowel disorders (without IBD) 11.74% vs. 4.5% (95% CI 5.72–6.68%), CNS/cranial anomalies 12.45% vs. 1.19% (95% CI 9.41–10.38%), diabetes mellitus type I (DM1) 0.79% vs. 0.34% (95% CI 0.3–0.6%), muscular dystrophy 0.47% vs 0.05% (95% CI 0.26–0.49%), sleep disorders 1.12% vs. 0.14% (95% CI 0.79–1.14%). Autoimmune disorders (excluding DM1 and IBD) were not significantly different at 0.67% vs. 0.68% (95% CI −0.14-0.13%). Three of the studied comorbidities increased significantly when comparing ages 0–17 vs 18–34 with p<0.001: Schizophrenia (1.43% vs. 8.76%), diabetes mellitus type I (0.67% vs. 2.08%), IBD (0.68% vs. 1.99%) whereas sleeping disorders, bowel disorders (without IBD) and epilepsy did not change significantly.

Conclusions

The comorbidities of ASD encompass disease states that are significantly overrepresented in ASD with respect to even the patient populations of tertiary health centers. This burden of comorbidities goes well beyond those routinely managed in developmental medicine centers and requires broad multidisciplinary management that payors and providers will have to plan for.

lilady

Why didn't you link to the BMJ article ASD Researcher? Still *cherry-picking*, eh?

Here's is the article, published in the BMJ, that clearly shows Wakefield deliberately labeled some of his study subjects as having "regressive autism". The article shows how he deliberately falsified chart notes to indicate "regressive autism" that appeared right after the MMR triple jab was administered, how the parents were referred (through JABS an anti-vaccine organization and through the lawyer that Wakefield received payments totaling $750.000 (USD) from.

And, most important Wakefield linked the "autistic enterocolitis" exclusively to the triple antigen MMR jab...in preparation for the marketing of his own single antigen measles vaccine.

http://briandeer.com/solved/bmj-wakefield-1-2.htm

How the case against the
MMR vaccine was fixed

First to crack was “regressive autism,” the bedrock of his allegations. “Bear in mind that we are dealing with regressive autism in these children, not of classical autism where the child is not right from the beginning,” he later explained, for example, to a United States congressional committee.

But only one—child 2—clearly had regressive autism. Three of nine so described clearly did not. None of these three even had autism diagnoses, either at admission or on discharge from the Royal Free.

The paper did not reveal that two of this trio were brothers, living 60 miles south of the hospital. Both had histories of fits and bowel problems recorded before their MMR vaccinations. The elder, child 6, aged 4 years at admission, had Asperger’s syndrome, which is distinct from autism under DSM-IV, is not regressive, and was confirmed on discharge. His brother, child 7, was admitted at nearly 3 years of age without a diagnosis, and a post-discharge letter from senior paediatric registrar and Lancet coauthor David Casson summarised: “He is not thought to have features of autism.”

The third in the trio, child 12, was enrolled on the advice of the brothers’ mother—reported in media to be a JABS activist, and who had herself “only relatively recently” blamed the vaccine. Child 12 was aged 6 at admission and had previously been assessed for possible Asperger’s syndrome at Guy’s Hospital, London, by a renowned developmental paediatrician. She diagnosed “an impairment in respect of language”—an opinion left undisturbed by Berelowitz.

Mrs 12 was a GMC witness at its mammoth hearing, which between July 2007 and May 2010 ran for 217 days. She explained that the brothers’ mother had made her suspicious of MMR and had given her Barr’s and Wakefield’s names. Mrs 12 then approached them and filed a statement for legal aid before her son was referred.

“It was like a jigsaw puzzle—it suddenly seemed to fit into place,” she told the panel, describing how she concluded, four years after the boy was vaccinated, that MMR was to blame for his problems. “I had this perfectly normal child who, as I could see, for no apparent reason started to not be normal.”

The 12 children were admitted between July 1996 and February 1997, and others had connections not revealed in the paper, almost as striking as the trio’s. The parents of child 9 and child 10 were contacts of Mrs 2, who ran a group that campaigned against MMR. And child 4 and child 8 were admitted—without outpatient appointments—for ileocolonoscopy and other invasive procedures, from one Tyneside general practice, 280 miles from the Royal Free, after advice from anti-MMR campaigners.

Pre-existing problems

Both child 4 and child 8 were among the eight whose parents were reported to have blamed the vaccine. But although the paper specified that all 12 children were “previously normal,” both had developmental delays, and also facial dysmorphisms, noted before MMR vaccination.

In the case of child 4, who received the vaccine at age 4 years, Wakefield played down problems, suggesting that early issues had resolved. “Child four was kept under review for the first year of life because of wide bridging of the nose,” he reported in the paper. “He was discharged from follow-up as developmentally normal at age 1 year.”

But medical records, presented by the GMC, give a different picture for this child. Reports from his pre-MMR years were peppered with “concerns over his head and appearance,” “recurrent” diarrhoea, “developmental delay,” “general delay,” and restricted vocabulary. And although before his referral to Wakefield his mother had inquired about vaccine damage compensation, his files include a report of a “very small deletion within the fragile X gene,” and a note of the mother’s view that her concerns about his development had begun when he was 18 months old.

“In general, his mother thinks he developed normally initially and subsequently his problems worsened, and he lost some of his milestones, but he subsequently improved on a restrictive exclusion diet,” wrote his general practitioner, William Tapsfield, referring the boy, then aged 9, after a phone conversation with Wakefield. “The professionals who have known [child 4] since birth don’t entirely agree with this, however, and there is a suggestion that some of his problems may have started before vaccination.”

Similarly with child 8, who was also described in the Lancet as having overcome problems recorded before vaccination. “The only girl . . . was noted to be a slow developer compared with her older sister,” the paper said. “She was subsequently found to have coarctation of the aorta. After surgical repair of the aorta at the age of 14 months, she progressed rapidly, and learnt to talk. Speech was lost later.”

But Wakefield was not a paediatrician. He was a former trainee gastrointestinal surgeon with a non-clinical medical school contract. And his interpretation differed from that of local consultants (including a developmental paediatrician and a geneticist) who had actually looked after the girl. Her doctors put the coarctation side by side with the delay and dysmorphism, and noted of her vocabulary that, before MMR at 18 months, she vocalised only “two or three words.”

“[Child 8’s] mother has been to see me and said you need a referral letter from me in order to accept [child 8] into your investigation programme,” the general practitioner, Diana Jelley, wrote to Wakefield at referral, when the girl was aged 3 and a half years. “I would simply re-iterate . . . that both the hospital and members of the primary care team involved with [child 8] had significant concerns about her development some months before she had her MMR.”

The girl’s general practice notes also provide insight into the background to the 12 children’s referrals. After person(s) unknown told Mrs 8 that her daughter may have inflammatory bowel disease, Jelley wrote: “Mum taking her to Dr Wakefield, Royal Free Hospital for CT scans/gut biopsies ?Crohn’s—will need ref letter—Dr W to phone me. Funded through legal aid.”

The child was “pale”

The remaining five children served Wakefield’s claims no better. There was still no convincing MMR syndrome. Child 1, aged 3 years when he was referred to London, lived 100 miles from the Royal Free, and had an older brother who was diagnosed as autistic. Child 1’s recorded story began when he was aged 9 months, with a “new patient” note by general practitioner Andrea Barrow. One of the mother’s concerns was that he could not hear properly—which might sound like a hallmark presentation of classical autism, the emergence of which is often insidious. Indeed, a Royal Free history, by neurologist and coauthor Peter Harvey, noted “normal milestones” until “18 months or so.”

Child 1 was vaccinated at 12 months of age, however. Thus neither 9 nor 18 months helped Wakefield’s case. But in the Lancet, the “first behavioural symptom” was reported “1 week” after the injection, holding the evidence for the lawsuit on track.

Step 1 to achieve this: two and a half years after the child was vaccinated, Walker-Smith took an outpatient history. Although the mother apparently had no worries following her son’s vaccination, the professor elicited that the boy was “pale” 7-10 days after the shot. He also elicited that the child “possibly” had a fever, and “may” have been delirious, as well as pale.

“It’s difficult to associate a clear historical link with the MMR and the answer to autism,” Walker-Smith wrote to the general practitioner, with a similar letter to Wakefield, “although [Mrs 1] does believe that [child 1] had an illness 7-10 days after MMR when he was pale, ?fever, ?delirious, but wasn’t actually seen by a doctor.”

Step 2: for the Lancet, Wakefield dropped the question marks, turning Walker-Smith’s queries into assertions. And, although Royal Free admission and discharge records refer to “classical” autism, step 3, the former surgeon reported “delirium” as the first “behavioural symptom” of regressive autism, with, step 4, a “time to onset” of 7 days.

So here—behind the paper—is how Wakefield evidenced his “syndrome” for the lawsuit, and built his platform to launch the vaccine scare.

“It is significant that this syndrome only appeared with the introduction of the polyvalent MMR vaccine in 1988 rather than with the monovalent measles vaccine introduced in 1968,” he claimed in one of a string of patents he filed for businesses to be spun from the research. “This indicates that MMR is responsible for this condition rather than just the measles virus.”

Three of the four remaining children were seen in outpatients on the same day—in November 1996. None of their families were reported in the paper as blaming the vaccine. Child 5, from Berkshire, aged 7 at admission, had received MMR at 16 months. The paper reported concerns at 18 months, but the medical records noted fits and parental worries at 11 months. Child 9, aged 6, from Jersey, also had MMR at 16 months. His mother dated problems from 18-20 months. Child 10, aged 4, from south Wales, contracted a viral infection, which was suspected by parents and doctors to have caused his disorder, four months after his vaccination.

“Behavioural changes included repetitive behaviour, disinterest in play or head banging,” said a question and answer statement issued by the medical school, concerning the Lancet 12, on the day of the paper’s publication.
Case selection

Another discrepancy to emerge during the GMC hearing concerned the number of families who blamed MMR. The paper said that eight (1, 2, 3, 4, 6, 7, 8, and 11) linked developmental issues with the vaccine. But the total in the records was actually 11. The parents of child 5, 9 and 12 were also noted at the hospital as blaming the vaccine, but their stated beliefs were omitted from the journal.



Science Mom

Is there a particular reason that you didn't cite the Columbia U paper pretend professor ASD researcher blackheart? Here it is: http://www.plosone.org/article/info%3Adoi/10.1371/journal.pone.0003140

Some researcher you are. Don't you know what selection bias and generalisability are?

lilady

Do you mean this paper, pretend professor ASD researcher blackheart?

http://www.plosone.org/article/info%3Adoi/10.1371/journal.pone.0003140

Abstract

Background:

The presence of measles virus (MV) RNA in bowel tissue from children with autism spectrum disorders (ASD) and gastrointestinal (GI) disturbances was reported in 1998. Subsequent investigations found no associations between MV exposure and ASD but did not test for the presence of MV RNA in bowel or focus on children with ASD and GI disturbances. Failure to replicate the original study design may contribute to continued public concern with respect to the safety of the measles, mumps, and rubella (MMR) vaccine.

Methodology/Principal Findings:

The objective of this case-control study was to determine whether children with GI disturbances and autism are more likely than children with GI disturbances alone to have MV RNA and/or inflammation in bowel tissues and if autism and/or GI episode onset relate temporally to receipt of MMR. The sample was an age-matched group of US children undergoing clinically-indicated ileocolonoscopy. Ileal and cecal tissues from 25 children with autism and GI disturbances and 13 children with GI disturbances alone (controls) were evaluated by real-time reverse transcription(RT)-PCR for presence of MV RNA in three laboratories blinded to diagnosis, including one wherein the original findings suggesting a link between MV and ASD were reported. The temporal order of onset of GI episodes and autism relative to timing of MMR administration was examined. We found no differences between case and control groups in the presence of MV RNA in ileum and cecum. Results were consistent across the three laboratory sites. GI symptom and autism onset were unrelated to MMR timing. Eighty-eight percent of ASD cases had behavioral regression.

Conclusions/Significance:

This study provides strong evidence against association of autism with persistent MV RNA in the GI tract or MMR exposure. Autism with GI disturbances is associated with elevated rates of regression in language or other skills and may represent an endophenotype distinct from other ASD.

ASD Researcher

So you are accepting this paper on it's scientific merits then.

'Autism with GI disturbances is associated with elevated rates of regression in language or other skills and may represent an endophenotype distinct from other ASD.'

Thanks you just made my case ...Science Mom will be pleased that you have joined me.

ASD Researcher

Science Mom

One begins to suspect that your google skills whilst showing some improvement need further work.

There are in fact two studies 1. that looked at the question of MMR and GI titled.

Lack of Association between Measles Virus Vaccine and Autism with Enteropathy: A Case-Control Study

http://www.plosone.org/article/info%3Adoi/10.1371/journal.pone.0003140

it clearly stated for ...

Median AUT onset age was 13.5 (7.0) months (Table 2). Cases had a high rate of CPEA-defined behavioral regression (loss of language and/or other skills following acquisition), 88%, compared to published rates of 20–40% for the general ASD population

2. the second paper published in 2011

Impaired carbohydrate digestion and transport and mucosal dysbiosis in the intestines of children with autism and gastrointestinal disturbances.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3174969/

"Regression (loss of language and/or other skills following acquisition) is reported in 20% to 40% of individuals with autism, and some studies suggest higher rates of GI symptoms in ASD subjects with regression than those without regression [27]. Eighty-seven percent of AUT-GI subjects in our study had behavioral regression

Some researcher you are. Don't you know what selection bias and generalisability are?

Yes but unless you can show evidence to the contrary it will have to stand. You seem to have a hard time taking the scientific and medical evidence from paediatric gastroenterologists into balance ?

You can always pitch your questions to Brent Williams at Columbia University. I'm sure he'll be interested.

There's also lots of other evidence about the significance of the GI tract disease and disorder in Autism ... thank goodness for the children with severe disabilities that we had doctors and professors like John Walker-Smith to begin the process that has led to better care and treatment for very sick children.

---------------------------

Anxiety, Sensory Over-Responsivity, and Gastrointestinal Problems in Children with Autism Spectrum Disorders.

http://www.ncbi.nlm.nih.gov/pubmed/22850932

Twenty-four percent of the sample experienced at least one type of chronic GI problem (constipation, abdominal pain, bloating, diarrhea, and/or nausea lasting three or more months).

Children with each type of GI problem had significantly higher rates of both anxiety and sensory over-responsivity.

Sensory over-responsivity and anxiety were highly associated, and each provided unique contributions to the prediction of chronic GI problems in logistic regression analyses.

The results indicate that anxiety, sensory over-responsivity and GI problems are possibly interrelated phenomenon for children with ASD, and may have common underlying mechanisms.

ndavis

not an ASD Researcher:

Honestly, most readers will recognize that if you are compelled to resort to obfuscation and misdirection in an effort to support your argument, you have a weak argument. As you undoubtedly understand, Deer was discussing the particular children in the Lancet study rather than all children with ASD.

However, you elected to cast the argument as something like this: (1) Deer wrote that several of the Lancet 12 did not have black hair; (2) independent research shows that many children with ASD who were not among in the Lancet 12 have black hair; therefore (3) Deer lied.

That’s sad.

Deer based his specific claims on the medical records of (11 of the 12) Lancet children, as disclosed in the Fitness to Practice (Misconduct) that resulted in Wakefield being struck off. You discuss other children.

ASD Researcher

Top posted. I must admit I don't think you've examined this issue for very long or am I mistaken ?

Mark McA

Wakefraud was caught red-handed falsifying his research FOR MONEY. He stood to make millions if he could convince enough people to avoid the MMR. Look it up.

Anti-vaxxers may still believe the lies, but they also believe germs don't cause disease... (Google "Age of Autism Germ Theory" and see for yourself.)

Nutters.

Twyla

No, he wasn't. No, he didn't.

Most people with vaccine concerns are not "anti-vaxxers" and do believe that germs cause disease.

Again, for more info on Dr. Andrew Wakefield:

"An Elaborate Fraud Series: Brian Deer, BMJ, Murdoch, Dr. Andrew Wakefield"
http://www.ageofautism.com/exclusives.html

"Who is Dr. Andrew Wakefield" - by Mary Holland
http://vaccineepidemic.com/images/vech25.pdf
footnotes:
http://vaccineepidemic.com/images/vech25notes.pdf

"Articles of Interest"
http://www.wesupportandywakefield.com/

lilady

We have read the GMC transcripts and the GMC decision to revoke his license, Twyla.

We have read Brian Deer's articles and he has proven that Wakefield was "on the payroll" for a his "expertise" on autistic enterocolitis...even before he saw children at the Royal Free Hospital and ordered all the not-medically-indicated invasive, painful and sometimes dangerous tests.

He sought fame and fortune and he got what he deserved; infamy and disgrace.

Twyla

He sought to help children with autism and severe bowel disease. He sought to understand their conditions better.

He did not order the diagnostic tests - John Walker Smith did that. World renowned pediatric gastroenterologist John Walker Smith, who was recently vindicated in court and his license to practice medicine restored.

He did earn a living from his expertise on bowel disease - no crime in that.

The parents praised the treatment their children received and said that:

"All of our children were referred to Professor Walker-Smith in the proper way in order that their severe, long-standing and distressing gastroenterological symptoms could be fully investigated and treated by the foremost paediatric gastroenterologists in the UK. Many of us had been to several other doctors in our quest to get help for our children but not until we saw Professor Walker-Smith and his colleagues were full investigations undertaken.

"We were all treated with utmost professionalism and respect by all three of these doctors. Throughout our children’s care at the Royal Free Hospital we were kept fully informed about the investigations recommended and the treatment plans which evolved. All of the investigations were carried out without distress to our children, many of whom made great improvements on treatment so that for the first time in years they were finally pain free."
http://www.ageofautism.com/2010/02/no-parent-ever-complained-to-gmc-public-statement-from-lancet-families-supports-the-mmr3.html

Also see:
http://www.cryshame.com/

whiteandnerdy

Twyla,

Or one could read what the court actual said.....that vaccines don't cause autism and in fact the court explicitly questioned the integrity of those that claim otherwise.

Similarly one can easily find that Walker-Smith agrees that vaccines don't cause autism....and how the children were not referred in the proper way...but rather in a clearly fraudulent way.

Again....all your references are from notorious anti-vaccs and they are clearly strangers to the truth....this is obvious to anyone that cares enough to fact-check.

W&N

Science Mom

"He did not order the diagnostic tests - John Walker Smith did that. World renowned pediatric gastroenterologist John Walker Smith, who was recently vindicated in court and his license to practice medicine restored."

You sure about that Twyla? Funny how the evidence is to the contrary:

"The Panel has already found proved that Dr Wakefield’s Honorary Consultant appointment was subject to a stipulation that he would not have any involvement in the clinical management of patients. On five occasions (child 2, 4, 5, 12 and 7) he ordered investigations on children, when he had no paediatric qualifications, and in contravention of the limitations on his appointment. The Panel considered this alone constituted a breach of trust of patients and employers alike."

From: http://www.gmc-uk.org/Wakefield_SPM_and_SANCTION.pdf_32595267.pdf


"He did earn a living from his expertise on bowel disease - no crime in that."

Except he took a lot of money from the LAB to manufacture evidence to support a court case, didn't declare it and falsified data. That is a crime in the real world. But he was "just doing it for the children" right Twyla?

"The parents praised the treatment their children received and said that: "

Not all the parents praised him and the ones that did had a vested interest (read: money from a lawsuit) in what Wakefield manufactured.

lookinglass

Twyla thanks for putting up the links, especially the one by Mary Holland, a brilliant study, the best I have come across. I had to type it in though as none of these links are working for me, don't know about others.

whiteandnerdy

As you very well know Wakefield's fraud includes:
(i) Lying about his funding/conflict of interests in the Lancet paper,
(ii) Falsifying testing results,
(iii) Fabricating clinical data,

In short, pretty much everything Wakefield has done on autism.

Your links are clearly not truthful. But rather obvious misinformation from folks that make money deceiving parents.

Bottom line: the facts are all public record for anyone interested in the truth.

W&N

lookinglass

White and, what an appropriate name,.Nerdy
Bottom line is my friend. you are talking a load of b--lls. And there is more than enough proof to the contrary to your fraudulent allegations out there for all to see, if you or your like can be bothered to read.

whiteandnerdy

Hey Lookingglass,

This is really, really simple. Take point (i).

The Lancet's instructions to authors:
" All sources of funding should be declared as an acknowledgment at the end of the text."

Further, the funding sources must be detailed in the Author Statements letter that Wakefield signed and sent to the Lancet's editors.

If you are correct, then you will be able to point out in the Lancet paper where Wakefield acknowledged the funding.

If you can't point this disclosure out then Wakefield's paper is fraudulent and he must have lied to the editors and hid his funding.

Of course if you don't care then we will get the standard anti-vaccs vent that does anything but deal with the facts.

W&N

lookinglass

Oh WTFR am I bothering with this stupidity on here? I am bothering because Twyla has done sterling work on here for hours all by herself (or himself?) and I wanted him/her to know that some of us out here appreciate it.
There is no GREAT DEBATE. There is only lies, lies and more lies from one fraudulent non medical journalist with a massive narcisstic personality disorder and a personal hatred of the one man who will not talk to him because he has better things to do. It really is pointess all you Deer accolytes immediately hurling abuse right back at this poster because what does it achieve? Nada. Nil. Nothing my friends. You followers of the Gospel according to Brian will shortly be made aware of how fraudulent his doctrines are, but I know that even if you were told by your President tomorrow that Wakefield is innocent of all charges, you would still not be convinced. If Andrew Wakefield was completely exonerated by the GMC tomorrow, your absolute trust in this sad trumped up boastful little Pullitzer Prize (Ha!) winning journalist, is so entrenched it will never be removed, not even surgically. So where is the debate? There isn't one. There never has been one. There never will be one.
I am not a scientist or a medic. Neither do I have an autistic member of my family thanks be to God. I do have M.E. however and believe there are links with ASD and all auto immune diseases. I am an artist and a writer, with a totally different mindset to scientists, (but I admire some of them!) and I am here because I hope to learn more about my own condition and because I do not follow the herd when it comes to drugs (or anything else) and because I have grandchildren and because I am someone who once met Wakefield. (I spent my adult lfe in the vicinity of the much admired and much loved Royal Free Hospital, situated in a beautiful leafy part of north London on the edge of Hampstead Heath. A few of my friends had babies there and one died there.)
I liike this man. I know that he is honest, and caring and utterly trustworthy. There is the truth and there are lies. But I also know for sure that in the end people believe what they want to believe. I want to beleve in my gut instincts. And I do. That's all one can say. W e each follow our own path in life.

Science Mom

@ lookinglass, Twyla has done nothing but post propaganda from AoA, a known repository for pseudoscience and Wakefield worship. Do you honestly think that Brian Deer is the only source? He is an authoritative source on Wakefield's fraud and his work has withstood scrutiny from legal challenges. There are numerous scientific studies that cannot find any link between MMR and autism, none published by Brian Deer. These data, taken together paint the whole picture of how Wakefield fixed the data and why.

I agree with you on one point though; there is no debate. If Deer is so angry with Wakefield for "not talking to him because he has better things to do" then why does Wakefield follow him around and keep suing him? Why do his sad rump of disciples keep writing about him?

Science Mom

Twyla, why don't you tell us what Immunospecifics Biotechnologies Ltd is, who started it and what the business plan and products were.

Can you really not see how ridiculous your links are? Self-serving tosh that cannot withstand a shred of scrutiny. Why aren't you citing real media stories and original research? Can't find your way out of that box?

ASD Researcher

Why not ... here's the patent application with the full name and address of the Royal Free Hospital at the top as the Patent Holder.

Perhaps you should look up Intellectual Property rights

http://www.bmj.com/highwire/filestream/402391/field_highwire_fragment_image_l/0.jpg

Now over to you show us the documentation on Wakefield's supposed trust account ?

Science Mom

"Why not ... here's the patent application with the full name and address of the Royal Free Hospital at the top as the Patent Holder."

Yea, two little problems there (also pretend professor) blackheart, Royal Free didn't even know they were listed as the patent holder until after the fact. And they relinquished all rights to Wakefield when he left RF because they didn't want that dirt on their hands: http://wakefieldgmctranscripts.blogspot.com/2012/02/gmc-fitness-to-practice-hearing-for.html

The second problem is is that if you are going to try and save Twyla from further embarrassment, you shouldn't embarrass yourself by not even answering the question. What is Immunospecifics Biotechnologies, Ltd. who started it and what the business plan and products were.

lilady

Lest we forget young Jack Piper...who suffered irreparable harm from Wakefield's "team" at the Royal Free Hospital.

http://www.dailymail.co.uk/news/article-500659/500-000-payout-autistic-boy-left-fighting-life-used-MMR-guinea-pig.html

£500,000 payout for autistic boy left fighting for life after being used as an MMR guinea pig

By RACHEL ELLIS

Last updated at 21:43 08 December 2007

An autistic boy has won a £500,000 payout after a hospital at the centre of an MMR scandal carried out an operation that was "not clinically justified".

Jack Piper, then five, was left battling for life after the procedure, which his parents claim was carried out to establish links between his condition and bowel problems.

His bowel was perforated in more than 12 places during surgery at the Royal Free Hospital in Hampstead, North London.

At the time, the hospital was at the centre of a controversy after employee Dr Andrew Wakefield claimed that the triple measles, mumps and rubella (MMR) jab was linked to autism and bowel problems.

High Court papers alleged the colonoscopy procedure performed on Jack in 1998 was "not clinically indicated or justified".

They also claimed the "principal reason" for the surgery was to further research into links between autism and bowel conditions rather than Jack's clinical needs.

The documents also claimed that Jack's parents were not warned of the risks of the procedure or the "controversial and uncertain" link between autism and bowel conditions.

This meant the surgery was performed "without lawful consent" and was an "assault" on Jack.

The Royal Free Hospital insists that staff had gone through all the pros and cons with Jack's parents.

The colonoscopy was suggested by Professor Simon Murch.

He is being investigated by the General Medical Council over allegations that he carried out invasive tests including colonoscopies on 11 other children contrary to their best clinical interests.

Prof Murch, now professor of paediatrics and child health at Warwick Medical School, denies the charges.

If he is found guilty of serious professional misconduct, he could be struck off.

High Court judge David Mitchell last week approved a £482,300 cash settlement made to Jack by the Royal Free Hampstead NHS Trust.

The hospital admitted the operation itself was negligent and gave Jack and his family a public apology.

Claims by his parents that they could not give proper consent for the operation, and that the procedure amounted to assault, were not tested in court.

The NHS hospital could end up with a bill for a further £1million, depending on Jack's future care needs.

Jack, who lived in Hertfordshire before his family moved to York, had the operation, which went "catastrophically wrong", in November 1998.

He then spent two weeks in intensive care at Great Ormond Street Hospital in Central London.

He suffered multiple organ failure, including kidney and liver problems, a swollen brain and neurological problems. He has also developed epilepsy and suffered stomach ulcers.

The botched operation "significantly increased" his dependence on others.

Now aged 14, Jack needs round-the-clock care.

His father, Russell, said: "The award gives us, as a family, the best opportunity to ensure Jack's future quality of life is the best it can be in difficult circumstances."

A spokesperson for the Royal Free Hospital said: "The claim was settled amicably with Jack's family.

"The trust wishes Jack and his family the very best for the future."

How many more children will be harmed by Wakefield and his supporters?


Twyla

Press Release
Dr. Wakefield's response to The Mail on Sunday

I was saddened by the story of Jack Piper in today's Mail on Sunday, a national UK newspaper. Although I personally never had any dealings with Jack, nor any responsibility for or role in his care, I am aware of the fact that he suffered both a perforation during colonoscopy and a difficult post-operative recovery. Jack's care was negligent and this fact was admitted by the Royal Free Hospital. Extraordinarily, the consultant paediatric gastroenterologist responsible for performing the colonoscopy (not Dr. Simon Murch) left the procedure in the hands of an inexperienced junior doctor while he went off to perform a similar procedure in a private hospital. Strangely, this fact finds no mention in the article. While perforation is a rare but recognised complication of colonoscopy, in this instance its occurrence was inexcusable, negligent, and the basis for Jack's settlement.

Sadly and inaccurately, Jack's story portrays him as a victim of 'MMR experimentation' and a picture of me accompanies the story. I am informed that Jack was assessed by Dr. Murch at his parent's request, on the basis of his unexplained bowel symptoms. Dr. Murch clearly considered a colonoscopy to be clinically indicated. I had no role in any of these decisions, but have no reason to doubt Dr. Murch's expert judgment.

The case was settled on the basis of clinical negligence. The issues of experimentation and lack of informed consent were not tested in court, nor should they have been since they have no merit. But what a perfect opportunity to weave another lie into the gossamer of this tragic tale.

Andrew Wakefield

lilady

Typical weaselly words from your hero Wakefield. He's blaming Jack Piper's parents...in essence stating that they lied.

What are the clinical indications to perform colonoscopies on children, Twyla?

What are the clinical indications to perform lumbar punctures on children, Twyla?

Please provide links to the clinical indications for these invasive, painful, sometimes dangerous tests on children.

Twyla

Not weaselly words - quite straightforward. He states that he,"personally never had any dealings with Jack, nor any responsibility for or role in his care". Nothing weaselly about those words.

Why on earth are you asking me about colonoscopies? I'm not a gastroenterologist.

But, I obediently looked for some links. Here is one:

"The safety and effectiveness of colonoscopy in the investigation of lower gastrointestinal tract pathology in children has been established for more than 2 decades in Korea. Skill and experience have since advanced to the point that both diagnostic and therapeutic colonoscopy are now routinely performed by most pediatric gastroenterologists... Investigation of inflammatory bowel disease, whether for diagnosis or follow-up evaluation, and suspected colonic polyps are the most common indication for pediatric colonoscopy. The child who presents with signs and symptoms of lower gastrointestinal disorder should undergo colonoscopy with biopsy to make the diagnosis, as well as to help determine the appropriate therapy...

"In conclusion, the child who presents with signs and symptoms of lower GI disorder should undergo colonoscopy with biopsy to make the diagnosis, as well as to help determine the appropriate therapy. Colonoscopy is a safe procedure in the pediatric population."
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005213/

lilady

Here's what Wakefield had to say about the reason he ordered colonoscopies on the children in his study, Twyla. Check out Deer's website for the indications for performing colonoscopies on a child, that were in existence in the U.K. at the time of his tenure at the the Royal Free Hospital

http://briandeer.com/wakefield/andi-interview.htm

You still haven't supplied the clinical indications for performing a lumbar puncture on a child, Twyla.

It seems to me that you are defending Wakefield as a compassionate brave maverick doctor whose license to practice medicine was unfairly and unjustifiably revoked by the GMC...without ever researching for yourself whether or not the tests that he ordered which were painful, invasive and not-medically-indicated were justified. You should have read the GMC transcripts Twyla.

Dyson

"colonoscopy is a safe procedure in the pediatric population"

Yeah, I bet that's what the researchers said to Jack's parents before they chopped him up.

Twyla

I was remembering today how Keith Olbermann had called Dr. Wakefield the "Worst Person in the World" on an episode of his show Countdown, but then did an about face when he realized the extent of Brian Deer's conflict of interest: "The guy who wrote the article about the investigation [Deer] never mentioned he was the complainant who precipitated the investigation." So the next day, Brian Deer received the bronze medal for "Worst Person in the World".

See the video of Keith Olbermann here:
http://lacrossetribune.com/news/local/vaccine-autism-debate-coming-to-la-crosse/article_88fe3612-0a92-11e2-bf97-0019bb2963f4.html?mode=comments

Read David Kirby's excellent article about this here:
http://www.huffingtonpost.com/david-kirby/keith-olbermann-todays-be_b_166103.html

Science Mom

""The guy who wrote the article about the investigation [Deer] never mentioned he was the complainant who precipitated the investigation." "

Still making that silly claim Twyla. Why don't you explain to our viewing audience how Brian Deer was the complainant. Please provide the complaint that Mr. Deer submitted; surely you have it somewhere in your link dumps.

AutismNewsBeat

Here is Brian Deer's Feb., 2009 response to Olbermann's slander:

"You were apparently supplied with your baseless allegations by a New York-based freelance journalist, David Kirby, who has made substantial sums of money through attacking childhood vaccines, and who is an advisor to Wakefield. Extraordinarily, you even supplied Kirby with a copy of the script of your attack on me, prior to broadcast, and thus appear to have acted in cahoots with him. Kirby was sufficiently motivated, and stupid, to publish your script on a website before the item was aired.

"Your defamation of me has been taken up by others, and you are plainly responsible for this. You have no possible defence, since your claims are simply false. They were fabricated and placed with you by antivaccine campaigners and cranks. You can argue no privilege or free speech right to make such false allegations, not least since you published them with complete disregard for their truth or falsity. NBC’s lawyers will no doubt explain to you the particular difficulties of such conduct in the UK jurisdiction."

whiteandnerdy

Or, someday you might try fact-checking. As has been pointed out many times before, the GMC has been very clear--Deer was not the complainant.

Why don't you care that your anti-vacc sources get pretty much everything wrong?

W&N

AutismNewsBeat

Olbermann caves to anti-vaccine lobby

http://autism-news-beat.com/archives/318

truthtalker

This really is not about Wakefield. His study has been replicated and supported by countless others around the world. Yet you never hear this acknowledged. Those who are determined to deny the link between vaccines and autism will continue to twist the data, statistics, lie through their teeth and whatever else they must do to disprove a connection. They do not care about the children, but their own interests. Here is a list of some of the studies that support Wakefield's original case study.
Science and Research

Regressive Autism, Ileal-Lymphoid Nodular Hyperplasia, Measles Virus and MMR Vaccine
Summary of Published Studies Offering Evidence for Linkages

By David Thrower

(download pdf)

This note summarizes:
• clinical evidence for the link between autism and a novel form of inflammatory bowel disease
• clinical evidence for the link between inflammatory bowel disease and measles virus
• clinical evidence for the link between measles virus and vaccination with MMR
• some of the other wider safety concerns over MMR

(A) The Link Between Autism and a Novel Form of Inflammatory Bowel Disease

There is now ample evidence, confirmed by independent groups of researchers, of a link between regressive autism and a novel form of inflammatory bowel disease. Full publication references are at the end of these notes.
• The possible association between MMR vaccine, regressive autism and intestinal symptoms was first recounted by parents to Dr. Andrew Wakefield, a UK gastroenterologist at the Royal Free Hospital, London, in 1995. The first group of children presenting in this way to Wakefield and colleagues at the Royal Free were reported in The Lancet as a clinical case series in February 1998 (1). Although the interpretation put on this paper at the time was the subject of intense controversy - particularly in the absence of corroborative clinical research by other researchers at that time - the strong evidence of a hitherto-unreported link between autism and a novel intestinal disease, ileal-lymphoid nodular hyperplasia, has not been disputed, and still stands as an important initial clue as to the causes of regressive autism.

• A group of researchers led by Horvath (2) subsequently independently reported in 1999 upon patients with autism who had gastrointestinal symptoms, including a study of 36 children with autism that found grade I or II reflux esophagitis in 25 (69.4%), chronic gastritis in 15 (42%) and chronic duodenitis in 24 (67%).

• Further research published in September 2000 (3) by Wakefield, Anthony et al confirmed that ileal-lymphoid nodular hyperplasia (ILNH) was found in 54 out of 58 (93%) children with autism or other disorders (50 with autism, 5 Aspergers, 2 disintegrative disorder, one ADHD, one schizophrenia, one dyslexia), but only 5 out of 35 (14.3%) normal controls, pointing to a very strong ILNH-autism link.

• Research published in 2001 by Furlano, Anthony et al (4) reported on ileocolonoscopy performed on 21 consecutively-evaluated children with autistic spectrum disorders and bowel symptoms, and made “blinded” comparisons with 8 children who had a histologically normal ileum and colon, plus 10 developmentally-normal children with ILNH, 15 with Crohn's Disease, and 14 with ulcerative colitis. The study confirmed a distinct lymphocytic colitis in the children with ASD, in which the epithelium appeared particularly affected, offering further corroboration for gut epithelial dysfunction in autism.

• Research reported in 2001 by Buie (5) reported that, as a result of over 400 gastrointestinal endoscopies with biopsies and evaluation of digestive enzyme function, on children with autism, he had found the presence of chronic inflammation of the intestinal tract, although the incidence was less frequent than in the Royal Free Hospital group of patients reported by Wakefield et al, and that biopsy results indicated the presence of chronic inflammation of the digestive tracts, including esophagitis, gastritis and enterocolitis. Ileal lymphoid nodular hyperplasia, as first found by the Royal Free study, had been found in 15 of 89 children examined for it.

• A review (6) published in September 2002 by Wakefield, Anthony, Montgomery et al noted that as early as 1986, a researcher named Soddy had noted that recurrent gastrointestinal upsets were a constant feature of autistic children, and that in a systematic analysis of an unselected population of 385 children on the autistic spectrum, clinically-significant gastrointestinal symptoms occurred in 46%, compared with 10% of 97 developmentally-normal controls, strongly suggesting a gastrointestinal-autism link. Mucosal lesions in the small and large intestine were consistent with an autoimmune pathology, and suggested the possibility of an autoimmune response leading to cerebral damage.

• A June 2002 presentation (7) by Krigsman to the US Congressional Committee on Government Reform reported that a large percentage of his autistic patients suffered from chronic unexplained gastrointestinal symptoms. Of 43 patients, the majority had a clear history of developmental regression, after previous normal development, suffering gradual or precipitous decline between age 12 months and 18 months. Most regressive children also exhibited poor growth. Patients had undergone colonoscopy. Findings were that the lymphoid nodules of the terminal ileum were markedly enlarged, thus confirming the early work of the Royal Free team. Evaluation of biopsy specimens confirmed that 65% had colitis, 51% had active colitis, 40% had chronic colitis, 7% had eosinophilic colitis, 90% had lymphoid nodular hyperplasia of the terminal ileum, and 35% had neither active nor chronic nor eosinophilic colitis. Patterns of inflammation were patchy and unpredictable, but findings were similar and consistent from patient to patient within affected sub-groups.

• A November 2003 paper (8) published by Ashwood, Murch et al reported on the examination of 52 affected autistic children, compared with 25 histologically-normal developmentally-normal controls and a further 54 histologically-inflamed but developmentally-normal controls. Analysis of intestinal biopsies in regressive-autistic children indicated a novel lymphocytic enterocolitis with autoimmune features, though the precise linkage between the finding and cognitive functions still remained unclear. The study concluded that it provided further evidence of a pan-enteric mucosal immunopathology in children with regressive autism, that is distinct from other previously-known inflammatory bowel diseases.

• An April 2004 paper (9) by Torrente, Anthony et al identified, following earlier reports of lymphocytic colitis and small bowel enteropathy in children with regressive autism, that the gastritis in regressive autism was clearly distinct from that in Crohn's and other conditions, pointing to a distinctive form of gastritis being linked with regressive autism.

• A November 2004 paper (10) by Ashwood, Anthony et al found that molecules (cytokines) produced by immune cells in the intestine, that cause or control inflammation, showed an abnormal pattern in autistic children compared with non-autistic children. The pattern was different to other forms of intestinal inflammation, and the disease resembled a longstanding viral disease of the intestine, not unlike the intestinal inflammation seen on patients with other viral infections such as HIV-associated enteropathy (intestinal disease) that often accompanies infection with HIV.

• A February 2005 paper (11) by Jyonouchi, Geng et al further confirmed the original ileal-lymphoid nodular hyperplasia/regressive autism link first reported by the Wakefield team in 1998. The study again found evidence of marked inflammatory and immune abnormalities in children with autism associated with gastrointestinal symptoms.

• An April 2005 published letter (12) by Balzola, Barbon et al , Pan-Enteric IBD-Like Disease in a Patient with Regressive Autism Shown for the First Time by the Wireless Capsule Enteroscopy - Another Piece in the Jigsaw of this Gut/Brain Syndrome? , reported that a 28-year-old male with regressive autism, severe constipation, bloating, abdomen distension and symptoms of gastroesophageal reflux was examined. Gastroscopy under general anaesthesia revealed hemorrhagic gastritis with inflammatory pseudopolypsthat had reached the pylorum, with a pearl-necklace appearance, and a panenteric IBD-like disease consistent with previously-published descriptions of autistic enterocolitis was finally diagnosed. The wireless capsule images were the first to be obtained beyond the limits of the duodenum and terminal ileum, and demonstrated the potential for the entire bowel to be implicated in this inflammatory disease.

• A May 2005 study (13) by Balzola, Daniela et al reported on 9 consecutive patients (range 7-30 years) with autism and chronic intestinal symptoms (abdominal pain, bloating, constipation and/or diahorrea). Routine blood and stool tests and gastroscopy and colonoscopy with multiple biopsies were performed under sedation, and wireless enteroscopy capsules were used in three of the adult patients. Gastroscopy revealed mucosal gastritis in 4 patients, esophagitis in 1 patient and duodenitis in 1 patient, and histological findings showed chronic inflammation of the stomach and duodenum in 6 patients, inconsistent with celiac disease. The authors reported that preliminary findings were strongly consistent with previous descriptions of autistic enterocolitis, and supported a not-coincidental occurrence. They showed for the first time a small-intestinal involvement, suggesting a pan-enteric localization of this new inflammatory bowel disease.

• Also in 2005, a further paper (14) by Wakefield, Ashwood et al was published, assessing ileocolonic lymphoid nodular hyperplasia in ASD and normal control children. Some 148 consecutive children with ASD, with gastrointestinal symptoms, were investigated by ileocolonoscopy, with 74 ASD children and 23 normal controls undergoing upper gastrointestinal endoscopy. The presence of lymphoid nodular hyperplasia was significantly greater in ASD children compared with controls, in the ileum (129 out of 144, compared with 8 out of 27 controls), and in the colon (88 out of 148, compared with 7 out of 30 controls). Comparative percentages were 90% vs 30% and 59% vs 23%. This was whether or not controls had co-existent colonic inflammation. The severity of ILNH was significantly greater in ASD children compared with controls, with moderate-to-severe ILNH present in 98 out of 144 ASD children compared with 4 out of 27 controls; percentages were 68% and 15%. On histopathological examination, hyperplasic lymphoid follicles were significantly more prevalent in the ileum of ASD children (84 out of 138, or 61%) compared with normal controls (2 out of 23, or 9%). The data thus further corroborated the finding that ileal lymphoid nodular hyperplasia is a significant pathological finding in autistic children.

• Additionally in 2005, a study (15) was published by Gonzalez, Lopez et al , seeking evidence of immunological alterations in 68 autistic children ages 22 months to 11 years and presenting with digestive systems, and examining biopsies from their digestive tracts. Endoscopies and colosopies were undertaken, with biopsies of the esophagus, stomach, duodenum and colon, with verification of presence of inflammation, eosiophil infiltration, lymphoid nodular hyperplasia and CD-4 and CD-8 cells. The results were that lymphoid nodular hyperplasia was discovered in 2/68 esophagus, 6/68 stomachs, 8/68 duodenums and 36/68 (53%) of colons. Eosiophil infiltration with more than 20 eosiphils per field were found in 3/68 eosphagus, 1/68 stomach, 8/68 duodenum and 24/68 (35%) colons. Inflammatory reactions were found in 56/68 (82%) esophogitis, 64/68 (94%) gastritis, and all (100%) presented with duodenitis and colitis. CD-4/CD-8 relationship existed of >3 in 42/68 (62%) and <1 in 16/68. The authors concluded that the children presented immunological and immunohistochemical alterations of the biopsies of their digestive tracts, and that there was a significant finding of lymphoid nodular hyperplasia, eosiophilinfiltration, and that prevalence of greater CD-4 than CD-8 cells in the inflammation of the intestinal wall demonstrated in favour of a Th2 type allergic reaction.

Taken together, the above now provide very convincing evidence from a number of wholly-independent groups of researchers of a link between the novel inflammatory bowel disease of ileal lymphoid nodular hyperplasia and regressive autism.

(B) The Link Between Inflammatory Bowel Disease and Measles Virus

These autism/inflammatory bowel disease findings were followed by findings that linked the novel form of inflammatory bowel disease with persistent measles virus in the gut of affected children:
• A paper (16) by Uhlmann, Sheils et al , noting that measles virus nucleoprotein (N antigen) had been detected in association with follicular dendritic cells (FDC) in patients, and seeking molecular confirmation of this result, found that :solution phase RT PCR yielded specific measles virus N gene amplification in affected children (10/10), and identified distinct measles virus genome in FDC reactive follicular centres by in-cell RNA amplification. None of the normal controls showed any evidence of measles virus genome. The data highlighted a possible causal link between measles virus infection and ileo-colonic lymphoid nodular hyperplasia in affected children.

• A paper (17) presented in the year 2000 by Singh to the US House of Representatives Committee on Government Reform reported a hyperimmune response to the measles virus, with an association between measles virus antibody levels and incidence of brain autoantibody.

• An April 2000 paper (18) presented by O'Leary to the Committee on Government Reform reported the investigation whether measles virus was present n the gut biopsies of autistic children, and if so, where and how much. The paper reported that the biopsies of 24 out of 25 (96%) of the autistic children examined were positive for measles virus, and that amongst normal (non-autistic) controls, only 1 out of 15 children (6.6%) were positive, strongly suggesting a connection between measles virus and autism.

• A February 2002 paper (19) by Uhlmann, Wakefield, O'Leary et al investigated the presence of persistent measles virus in the intestinal tissue of 91 autistic patients with new-variant inflammatory bowel disease (ileal-lymphoid nodular hyperplasia, or ILNH). Patient samples were provided by the Royal Free Hospital, London. The patients were ages 3-14, and 77 out of 91 were male. There were 70 developmentally-normal controls ages 0-17 years, 47 out of 70 being boys. Of these, 19 had normal ileal biopsies, 13 had mild non-specific chronic inflammatory changes, 3 had ILNH and had been investigated for abdominal pain, 8 had Crohn's Disease, one had ulcerative colitis, and 26 had undergone appendicectomy for abdominal pain including appendicitis. The results were that 75 out of 91 patients with a histologically-confirmed diagnosis of ileal-lymphoid nodular hyperplasia and enterocolitis were positive for measles virus in their intestinal tissue, compared with 5 out of 70 controls. Using TaqMan RT-PCR techniques, 70 out of 91 affected children were positive for measles virus, compared with 4 out of 70 controls. Of the controls, measles virus was not detected in normal children or children with isolated ileal-lymphoid nodular hyperplasia. However, 4 out of 26 appendicectomy samples harboured measles virus genome; the study suggested that the prevalence of measles virus in the general population warranted further investigation. The study concluded that the data confirmed an association between the presence of gut pathology and of measles virus in children with developmental disorder. The study did not exclude the presence of alternative infections to measles virus.

• A February 2004 paper (20) presented by Singh to the US Institute of Medicine, Washington DC, measured antibodies in autistic children to five viruses, measles, mumps, rubella, CMV and human herpes virus 6. Researchers found that the antibody level of the measles virus alone, and not the other four, was significantly higher in autistic children than in normal children. The research also found a correlation between measles antibody and brain autoimmunity, which was marked by myelin basic protein antibodies. The two markers correlated in over 90% of the autistic children tested for them, suggesting a causal link between measles virus and autoimmunity in autism. The serology to other viruses and other brain autoantibodies did not show this correlation. This suggested a temporal link of measles virus in the etiology of autism.

An early-report presentation by Walker, Hepner et al , at the International Meeting for Autism Research, Montreal, June 2006, reported that PCR analysis on terminal ileum biopsy tissue from an initial 82 patients found 70 (85%) positive for measles virus f-gene amplicon. These preliminary results confirm earlier findings of measles virus RNA in the terminal ileum. Full publication of this study is anticipated.

The above studies provide significant evidence for a link between measles virus and ileal lymphoid nodular hyperplasia, with the latter's earlier-demonstrated onward link with regressive autism.

(C) The Link Between Measles Virus and Vaccination with MMR
• A July 2002 paper (21) presented by O'Leary reported that the strain of measles virus used in MMR had been detected in the gut tissue of 12 autistic children. Medical histories had indicated that each of the children had developed autism after the date of receipt of MMR, and none had exhibited outward signs of measles infection before becoming autistic.

• An April 2000 study (22) by Kawashima, Takayuki et al confirmed that, amongst 8 patients with Crohn's Disease, 3 patients with ulcerative colitis and 9 patients with autistic enterocolitis, and 8 children who were either healthy or who had SSPE, SLE or HIV-1, 1 out of 8 patients with CD, 1 out of 3 patients with UC and 3 out of 9 patients with autism were positive for measles virus. Controls were all negative. The sequences from patients with CD shared the characteristics of wild-strain measles virus. The sequences from patients with UC and from patients with autism were consistent with vaccine strain measles virus. These results were consistent with patients' medical histories, and point to a connection between autism and vaccine-strain measles virus.

• A May 2002 paper (23) by Singh, Nelson, Jensen and Bradstreet found that a significant percentage of autistic children examined had antibodies to myelin basic protein (up to 88% positive) and to MMR (up to 65% positive). Normal children did not exhibit these antibodies. The analysis of paired samples (serum and cerebral spinal fluid from 7 autistic children also revealed a high degree of serological association between MMR and myelin basic protein. Some 50% of CSF had MMR antibodies, 86% of CSF had MBP antibodies, 75% of sera had MMR antibodies and 100% of sera had MBP antibodies. Therefore there was a strong correlation between MMR antibodies and myelin basic protein antibodies. By using monoclonal antibodies, the authors characterized that the MMR antibodies were due to the measles sub-unit, but not to the mumps or rubella sub-units, of MMR. In the light of this, the authors suggested that in some cases of autism, MMR might cause autoimmunity, and it might be doing so by bringing on an atypical measles infection that manifests neurological symptoms.

• An earlier 1999 paper (24) by Bitnun has previously and independently confirmed the presence of measles virus in the brain tissue of a previously-healthy child following exposure to MMR, when the child had no history of wild measles infection.

• A February 2004 paper (25) by Bradstreet, O'Leary, Sheils et al to the US Institute of Medicine, and subsequently published later that year, reported that three children with regressive autism had undergone cerebrospinal fluid assessment, including for measles virus. All three had had concomitant onset of gastrointestinal symptoms and had already had measles virus genomic RNA detected in biopsies of ileal-lymphoid nodular hyperplasia. None of the cases nor non-autistic controls had any history of measles exposure other than possibly via MMR. Serum and cerebrospinal fluid samples were also evaluated for antibodies to measles virus and myelin basic protein. The result was that measles virus f-gene was present in the cerebrospinal fluid of all three autistic cases but not in non-autistic controls. Further, serum anti-myelin basic protein autoantibodies were detected in all children with autistic encephalopathy. Anti-MBP and measles virus antibodies were detected in the CSF of two cases, but the third had neither. The study concluded that the findings were consistent with a measles-virus etiology for autistic encephalopathy, indicating the possibility of a virally-driven cerebral immunopathology in some cases of regressive autism. The virus genome found in the autistic children was “exclusively consistent with vaccine strain”.

• A May 2006 study (26) by Wakefield, Stott and Limb investigated the hypothesis as to whether a dose-response effect of measles-containing vaccine on intestinal pathology existed. If it did exist, this would constitute evidence of a causal association. In the study, children with normal early development and autistic-like developmental regression were divided into two groups. Children were divided into two groups: some 23 re-exposed children, i.e. those who had received more than one dose of a measles-containing vaccine (MCV), and 23 children who had received only one dose of MCV. The groups were matched for sex, age and time that had elapsed from first exposure to time of endoscopy. Comparisons made included secondary gastrointestinal (GI) and related physical symptoms, and “observer-blinded” scores of endoscopic and histological disease. The results were that re-exposed children scored significantly higher than only-once-exposed for secondary physical symptoms, including incontinence, presence of severe ileal-lymphoid nodular hyperplasia, the number of biopsies with epithelial damage, and number of children with acute inflammation. Markers of acute inflammation include number of children affected, and proportion of biopsies affect. The conclusion of the study was that the data confirmed a re-challenge effect (i.e. a double-hit effect) of measles-containing vaccines on symptoms, and also confirmed a biological gradient effect upon intestinal pathology. These findings thus link exposure to measles-containing vaccines to autistic-like regression and enterocolitis. (Note: it was stated in April 2001 by the Vaccine Safety Committee of the US Institute of Medicine that in the context of MMR and autism “challenge re-challenge would constitute strong evidence of an association”.)

Taken together, with the Walker, Hepner et al study, the above points to MMR as the means by which measles virus enters and persists in the gut, leading to ileal-lymphoid nodular hyperplasia, and in turn leading to regressive autism. The evidence to fully explain the complete causational mechanism by which this occurs is still emerging, and clearly requires further urgent research.

The intestinal disease has the features of a viral disease. Measles virus is known to infect the intestine, and produces the features described originally by Wakefield and colleagues in 1998.

All the findings described in the 1998 Lancet report by the Wakefield team - including the discovery of a possible new type of inflammatory bowel disease, have therefore been subsequently independently confirmed by other researchers in the US, in Italy and in Venezuela.

The studies suggest that in some children, brain damage leading to autism may be secondary to, or occur in parallel with, a disease in the intestine, and that vaccine strain measles virus has become the prime suspect in this complex investigation.

The findings to date have important implications for our understanding and treatment of the complex disorder of regressive autism.

(D) Wider Safety Concerns Over MMR:

It is also instructive to examine the original, and any subsequent, safety studies of MMR.
• An authoritative independent review by the Cochrane Collaboration (27) of the safety studies of MMR vaccine concluded that “the design and reporting of safety outcomes in MMR vaccine studies, both pre- and post-marketing, are largely inadequate”. It further confirmed that neither before nor after the introduction of the MMR vaccine were proper safety trials carried out.

• A more recent review (28) from the same organization identified that safety studies for the single measles vaccine were better than those conducted for MMR: “We found only limited evidence of safety of MMR compared to the single component vaccines, that had a low risk of bias”. The authors of the Cochrane reviews were highly critical of the safety studies of MMR, which they stated “need to be improved”. Cochrane mentioned a specific concern that safety studies followed up the children involved for no more than three weeks, except for one study that lasted just six weeks.

• Concern over MMR's safety has been expressed (29) by a key former scientific adviser to the UK licensing authorities. Dr. Peter Fletcher , former Principal Medical Officer in the (then) UK Medicines Division, who was medical assessor to the Committee on Safety of Medicines, commented: “Evidence on safety was very thin” , and “Too few children were followed for a sufficient time... Big numbers were necessary, and computerised databases were already in place to permit this, but it was not done... Caution should have ruled the day... There should have been strong encouragement to conduct a 12-month observational study on 10,000-15,000 children...” (this was not done) "The granting of a product licence was premature.”

• A year-2000 review (30 by Wakefield & Montgomery examined early safety studies of MMR, by Buynak et al 1969, Stokes et al 1971, Minekawa et al 1974, Schwartz et al 1975, Crawford and Gremillion 1981, and Miller et al 1987. The Buynak study identified viral “interference”, but the follow-up period was only 12 days. The Stokes study revealed persistent gastrointestinal problems in the US trial children, but the follow-up was only 28 days. Stokes compared 228 MMR children with 106 unvaccinated controls. Data, from Philadelphia and Costa Rica and San Salvador, was merged - a major methodological error. Gastroenteritis was found to be significantly more common in the Philadelphia vaccines (24%) compared with the unvaccinated Philadelphia controls (5.6%). No significant difference was found between the vaccinated and the unvaccinated in Costa Rica and San Salvador because of high ambient levels of gastroenteritis anyway (50% in vaccines, 44% in controls). Combining all the data masked these instructive differences. There was also significant “unrelated” illness in 39% of Philadelphia vaccines (otitis, allergy, viral infection, abdominal pain), compared with 12.2% in controls. The potential relevance of this was not seen at time. The Minekawa study confirmed viral interference. The follow-up period was only 15 days. The Schwartz study also merged its data, so provided insufficient insight, and again follow-up was only 21 days. The study looked at two different populations, 282 children in Ohio and 926 children in Santo Domingo, Dominican Republic. Again, the merging of data from different countries was a serious error. No data was provided to permit analysis of adverse events. Crawford and Gremillion's study of USAF recruits confirmed viral interference, but the follow-up period was only 19 days. Some 512 vaccines were compared with 835 unvaccinated controls. The study noted increased fever and diarrhoea in those that received measles and rubella vaccines simultaneously. But the potential effect of trivalent vaccine was only seen as additive instead of potentially synergistic - a key point. The Eddes study (a small UK study) in 1991 compared reactions to MMR with monovalent measles vaccine. High rates of gastrointestinal disorders (41.9% and 37.8%) were found, but the authors dismissed these as normal background illness. The Dr. Elizabeth Miller study noted that diarrhoea was common (26% of vaccinees), but the follow-up again was only 21 days. This was a major missed opportunity to follow up a large cohort. The Stokes, Schwartz, Miller and Eddes studies were therefore all too small or too superficial to pick up uncommon adverse events. The Plesner et al study of gait disturbance following MMR ( Acta Paediatrica , 2000, 89, 58-63) confirmed an association, and indicated that more severe cerebellar ataxias following MMR may be associated with residual cognitive deficits.

Cochrane was forced to conclude that “the safety record of MMR is probably best attested by its almost universal use.” Or to put it another way, “the best evidence of MMR's safety we can find is that fact that it's being widely used” - hardly a scientific test of a product's actual safety, particularly when the evidence of problems is through a hitherto-unsuspected link between MMR and autism, that would not have been monitored prior to 1998.

References

( on the link between autism and a novel form of inflammatory bowel disease )

(1) Wakefield et al, Inflammatory Bowel Disease Study Group, Royal Free Hospital London, Ileal Lymphoid Nodular Hyperplasia, Non Specific Colitis and Pervasive Development Disorder in Children , Lancet, 28th February 1998

(2) Horvath, Papadimitiou et al, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Gastrointestinal Abnormalities in Children With Autistic Disorder , Journal of Pediatrics, 1999 November, Vol 135 (5), pp559-563

(3) Wakefield, Anthony et al, Enterocolitis in Children with Developmental Disorders , American Journal of Gastroenterology, Sept 2000, Vol 95, No. 9, pp2285-2295

(4) Furlano, Anthony et al, Colonic CD8 and T-Cell Infiltration With Epithelial Damage in Children with Autism , Journal of Pediatrics, 2001; 138; No. 3, 366-372

(5) Paper by Dr. Timothy Buie, Harvard Massachusetts General Hospital, presented to the Oasis 2001 Conference for Autism, Portland, Oregon, November 2001

(6) Wakefield, Anthony, Montgomery et al, Inflammatory Bowel disease Study Group, Royal Free Hospital, University College Medical School, London, and Coombe Women's Hospital and Trinity College Dublin, The Concept of Enterocolonic Encepalopathy, Autism and Opioid Receptor Ligands , Aliment Pharmacological Ther, 16: pp663-674

(7) Presentation by Krigsman to the US Congressional Committee on Government Reform's June 2002 hearing, The Status of Research into Vaccine Safety and Autism, held in Washington DC

(8) Ashwood, Murch et al, Royal Free Hospital, London, Intestinal Lymphocyte Populations in Children with Regressive Autism: Evidence for Extensive Mucosal Immunopathology , Journal of Clinical Immunology, Vol 23 No. 6 Nov 2003 pp504-517

(9) Torrente, Anthony et al, Centre for Pediatric Gastroenterology, Royal Free Hospital and University College Medical School, London, Focal-Enhanced Gastritis in Regressive Autism, With Features Distinct from Crohn's and Helicobacter Pylori Gastritis , American Journal of Gastroenterology, Vol 99, Issue 4, p598, April 2004

(10) Ashwood, Anthony et al, Spontaneous Mucosal Lymphocyte Cytokine Profiles in Children with Autism and Gastrointestinal Symptoms: Mucosal Immune Activation and Reduced Counter-Regulatory Interleukin-10 , Journal of Clinical Immunology, Vol 24, No. 6, November 2004

(11) Jyonouchi, Geng et al, Department of Pediatrics, New Jersey Medical School, Dysregulated Innate Immune Responses in Young Children with Autistic Spectrum Disorders - Their Relationship in Gastrointestinal Symptoms and Dietary Intervention , Neuropsychobiology, February 2005, 51 (2) pp77-85

(12) Letter by Balzola, Barbon et al, Department of Gastroenterology, Department of Neuropsychiatry for Children, Department of Pediatric Gastroenterology and Department of Biomedical Sciences and Human Oncology, University of Turin, Pan-Enteric IBD-Like Disease in a Patient with Regressive Autism Shown for the First Time by the Wireless Capsule Enteroscopy - Another Piece in the Jigsaw of this Gut/Brain Syndrome? , American Journal of Gastroenterology, 2005; 100 (4) p979

(13) Balzola, Daniela et al, Department of Gastroenterology, Department of Neuropsychiatry for Children, Department of Pediatric Gastroenterology and Department of Biomedical Science and Human Oncology, University of Turin, Autistic Enterocolitis - Autistic Enterocolitis: Confirmation of a New Inflammatory Bowel Disease in an Italian Cohort of Patients , paper presented to the American Gastroenterological Association, May 2005 and published in Gastroenterology 2005: 128 Suppl 2, A-303

(14) Wakefield, Ashwood et al, The Significance of Ileo-Colonic Lymphoid Nodular Hyperplasia in Children with Autistic Spectrum Disorder , European Journal of Gastroenterology and Hepatology, 2005, Vol 17 No. 8

(15) Gonzalez, Lopez et al, Endoscopic and Histological Characteristics of the Digestive Mucosa in Autistic Children with Gastrointestinal Symptoms: Preliminary Report , G.E.N. Suplemento Especial de Pediatria, no. 1, 2005; pp41-47


( on the link between inflammatory bowel disease and measles virus )

(16) Uhlmann, Sheils et al, Department of Pathology, Coombe Women's Hospital Dublin, Trinity College Dublin and Royal Free Hospital London, Measles Virus in Reactive Lympho-Nodular Hyperplasia and Ileo-colitis of Children

(17) Paper presented by Dr. Vijendra Singh, University of Michigan College of Pharmacy, to the US House of Representatives Committee on Government Reform, Washington DC, 2000

(18) Paper presented by Professor John O'Leary, Dublin Women's Hospital, to the US House of Representatives Committee on Government Reform, Washington DC, April 2000

(19) Paper By Uhlmann, Wakefield, O'Leary et al, Potential Viral Pathogenic Mechanism For New Variant Inflammatory Bowel Disease , Journal of Clinical Pathology, Molecular Pathology, 2002, 55, 0-6, published 6th February 2002

(20) Paper by Singh, Department of Biology Center for Integrated Biosystems, Utah State University, Logan, Autism, Vaccines and Immune Reactions , presented to the Institute of Medicine, Washington DC, February 2004


( on the link between measles virus and vaccination with MMR )

(21) Paper presented by O'Leary, Coombe Women's Hospital and Trinity College Dublin to the Pathological Society of Great Britain and Ireland, July 2002

(22) Kawashima, Takayuki et al, Detection and Sequencing of Measles Virus from Peripheral Mononuclear Cells from Patients with Inflammatory Bowel Disease and Autism , Digestive Diseases & Science, Vol 45, No. 4, April 2000, pp723-729

(23) Singh, Nelson, Jensen and Bradstreet, Abnormal Measles Serology and Autoimmunity in Autistic Children , Journal of Allergy and Clinical Immunology 109 (1) S232, January 2002, and also presented to the 102nd General Meeting of the American Society for Microbiology, Salt Lake City, Utah, May 2002

(24) Bitnun et al, Measles Inclusion-Body Encephalitis Caused by the Vaccine Strain of Measles Virus , Clinical Infectious Diseases Journal, 1999, 29 855-61 (October)

(25) Bradstreet, O'Leary, Sheils et al, Detection of Measles Virus Genomic RNA in Cerebrospinal Fluid in Children with Regressive Autism by TaqMan RT-PCR: A Report of Three Cases , summarized at the Institute of Medicine, February 2004 and subsequently published as Bradstreet, Dahr et al, Detection of Measles Virus Genomic RNA in Cerebrospinal Fluid of Children with Regressive Autism: A Report of Three Cases , Journal of American Physicians and Surgeons, Vol 9, No. 2 Summer 2004

(26) Wakefield, Stott and Limb, Gastrointestinal Comorbidity, Autistic Regression and Measles-Containing Vaccines; Positive Re-challenge and Biological Gradient , Medical Veritas 3 (2006) 796-802

Again, taken with the latest study by Walker, Hepner et al, this now provides evidence that it is highly likely that MMR vaccine is the source of the measles virus that is in turn linked via significant evidence with ileal lymphoid nodular hyperplasia, which in turn is strongly and convincingly linked with regressive autism.

( on wider safety concerns over MMR vaccine )

(27) Jefferson, Price et al, Unintended Events Following Immunisation with MMR; A Systematic Review , Vaccine, 2003; 21: pp3954-3960

(28) Demicheli, Jefferson et al, Vaccine For Measles, Mumps and Rubella in Children (Review) , The Cochrane Collaboration, published Wiley & Sons, UK, from The Cochrane Library, 2005, Issue 4, art. No. CD004407

(29) Commentary by Dr. Peter Fletcher, Journal of Adverse Drug Reactions & Toxicology, 2001, 20 (1), 47 63 Oxford University

(30) Wakefield & Montgomery Through A Glass Darkly (A Look Back At MMR's Safety Trials), Journal of Adverse Drug Reactions, 2000 19(4), 265-283

truthtalker

Sorry for the double post.

Mark McA

Don't worry, nobody read them.

AutismNewsBeat

The only thing those studies prove is that autistic people have intestines.

truthtalker

It does not matter how many studies are done. Those who insist on denying a link between vaccines and autism will continue to shift the data, statistics, lie through their teeth, and whatever else they must do to protect themselves and their precious vaccine dogma. Here are just some of the studies that support/replicate the work and claims of Wakefield.
Science and Research

Regressive Autism, Ileal-Lymphoid Nodular Hyperplasia, Measles Virus and MMR Vaccine
Summary of Published Studies Offering Evidence for Linkages

By David Thrower

This note summarizes:
• clinical evidence for the link between autism and a novel form of inflammatory bowel disease
• clinical evidence for the link between inflammatory bowel disease and measles virus
• clinical evidence for the link between measles virus and vaccination with MMR
• some of the other wider safety concerns over MMR

(A) The Link Between Autism and a Novel Form of Inflammatory Bowel Disease

There is now ample evidence, confirmed by independent groups of researchers, of a link between regressive autism and a novel form of inflammatory bowel disease. Full publication references are at the end of these notes.
• The possible association between MMR vaccine, regressive autism and intestinal symptoms was first recounted by parents to Dr. Andrew Wakefield, a UK gastroenterologist at the Royal Free Hospital, London, in 1995. The first group of children presenting in this way to Wakefield and colleagues at the Royal Free were reported in The Lancet as a clinical case series in February 1998 (1). Although the interpretation put on this paper at the time was the subject of intense controversy - particularly in the absence of corroborative clinical research by other researchers at that time - the strong evidence of a hitherto-unreported link between autism and a novel intestinal disease, ileal-lymphoid nodular hyperplasia, has not been disputed, and still stands as an important initial clue as to the causes of regressive autism.

• A group of researchers led by Horvath (2) subsequently independently reported in 1999 upon patients with autism who had gastrointestinal symptoms, including a study of 36 children with autism that found grade I or II reflux esophagitis in 25 (69.4%), chronic gastritis in 15 (42%) and chronic duodenitis in 24 (67%).

• Further research published in September 2000 (3) by Wakefield, Anthony et al confirmed that ileal-lymphoid nodular hyperplasia (ILNH) was found in 54 out of 58 (93%) children with autism or other disorders (50 with autism, 5 Aspergers, 2 disintegrative disorder, one ADHD, one schizophrenia, one dyslexia), but only 5 out of 35 (14.3%) normal controls, pointing to a very strong ILNH-autism link.

• Research published in 2001 by Furlano, Anthony et al (4) reported on ileocolonoscopy performed on 21 consecutively-evaluated children with autistic spectrum disorders and bowel symptoms, and made “blinded” comparisons with 8 children who had a histologically normal ileum and colon, plus 10 developmentally-normal children with ILNH, 15 with Crohn's Disease, and 14 with ulcerative colitis. The study confirmed a distinct lymphocytic colitis in the children with ASD, in which the epithelium appeared particularly affected, offering further corroboration for gut epithelial dysfunction in autism.

• Research reported in 2001 by Buie (5) reported that, as a result of over 400 gastrointestinal endoscopies with biopsies and evaluation of digestive enzyme function, on children with autism, he had found the presence of chronic inflammation of the intestinal tract, although the incidence was less frequent than in the Royal Free Hospital group of patients reported by Wakefield et al, and that biopsy results indicated the presence of chronic inflammation of the digestive tracts, including esophagitis, gastritis and enterocolitis. Ileal lymphoid nodular hyperplasia, as first found by the Royal Free study, had been found in 15 of 89 children examined for it.

• A review (6) published in September 2002 by Wakefield, Anthony, Montgomery et al noted that as early as 1986, a researcher named Soddy had noted that recurrent gastrointestinal upsets were a constant feature of autistic children, and that in a systematic analysis of an unselected population of 385 children on the autistic spectrum, clinically-significant gastrointestinal symptoms occurred in 46%, compared with 10% of 97 developmentally-normal controls, strongly suggesting a gastrointestinal-autism link. Mucosal lesions in the small and large intestine were consistent with an autoimmune pathology, and suggested the possibility of an autoimmune response leading to cerebral damage.

• A June 2002 presentation (7) by Krigsman to the US Congressional Committee on Government Reform reported that a large percentage of his autistic patients suffered from chronic unexplained gastrointestinal symptoms. Of 43 patients, the majority had a clear history of developmental regression, after previous normal development, suffering gradual or precipitous decline between age 12 months and 18 months. Most regressive children also exhibited poor growth. Patients had undergone colonoscopy. Findings were that the lymphoid nodules of the terminal ileum were markedly enlarged, thus confirming the early work of the Royal Free team. Evaluation of biopsy specimens confirmed that 65% had colitis, 51% had active colitis, 40% had chronic colitis, 7% had eosinophilic colitis, 90% had lymphoid nodular hyperplasia of the terminal ileum, and 35% had neither active nor chronic nor eosinophilic colitis. Patterns of inflammation were patchy and unpredictable, but findings were similar and consistent from patient to patient within affected sub-groups.

• A November 2003 paper (8) published by Ashwood, Murch et al reported on the examination of 52 affected autistic children, compared with 25 histologically-normal developmentally-normal controls and a further 54 histologically-inflamed but developmentally-normal controls. Analysis of intestinal biopsies in regressive-autistic children indicated a novel lymphocytic enterocolitis with autoimmune features, though the precise linkage between the finding and cognitive functions still remained unclear. The study concluded that it provided further evidence of a pan-enteric mucosal immunopathology in children with regressive autism, that is distinct from other previously-known inflammatory bowel diseases.

• An April 2004 paper (9) by Torrente, Anthony et al identified, following earlier reports of lymphocytic colitis and small bowel enteropathy in children with regressive autism, that the gastritis in regressive autism was clearly distinct from that in Crohn's and other conditions, pointing to a distinctive form of gastritis being linked with regressive autism.

• A November 2004 paper (10) by Ashwood, Anthony et al found that molecules (cytokines) produced by immune cells in the intestine, that cause or control inflammation, showed an abnormal pattern in autistic children compared with non-autistic children. The pattern was different to other forms of intestinal inflammation, and the disease resembled a longstanding viral disease of the intestine, not unlike the intestinal inflammation seen on patients with other viral infections such as HIV-associated enteropathy (intestinal disease) that often accompanies infection with HIV.

• A February 2005 paper (11) by Jyonouchi, Geng et al further confirmed the original ileal-lymphoid nodular hyperplasia/regressive autism link first reported by the Wakefield team in 1998. The study again found evidence of marked inflammatory and immune abnormalities in children with autism associated with gastrointestinal symptoms.

• An April 2005 published letter (12) by Balzola, Barbon et al , Pan-Enteric IBD-Like Disease in a Patient with Regressive Autism Shown for the First Time by the Wireless Capsule Enteroscopy - Another Piece in the Jigsaw of this Gut/Brain Syndrome? , reported that a 28-year-old male with regressive autism, severe constipation, bloating, abdomen distension and symptoms of gastroesophageal reflux was examined. Gastroscopy under general anaesthesia revealed hemorrhagic gastritis with inflammatory pseudopolypsthat had reached the pylorum, with a pearl-necklace appearance, and a panenteric IBD-like disease consistent with previously-published descriptions of autistic enterocolitis was finally diagnosed. The wireless capsule images were the first to be obtained beyond the limits of the duodenum and terminal ileum, and demonstrated the potential for the entire bowel to be implicated in this inflammatory disease.

• A May 2005 study (13) by Balzola, Daniela et al reported on 9 consecutive patients (range 7-30 years) with autism and chronic intestinal symptoms (abdominal pain, bloating, constipation and/or diahorrea). Routine blood and stool tests and gastroscopy and colonoscopy with multiple biopsies were performed under sedation, and wireless enteroscopy capsules were used in three of the adult patients. Gastroscopy revealed mucosal gastritis in 4 patients, esophagitis in 1 patient and duodenitis in 1 patient, and histological findings showed chronic inflammation of the stomach and duodenum in 6 patients, inconsistent with celiac disease. The authors reported that preliminary findings were strongly consistent with previous descriptions of autistic enterocolitis, and supported a not-coincidental occurrence. They showed for the first time a small-intestinal involvement, suggesting a pan-enteric localization of this new inflammatory bowel disease.

• Also in 2005, a further paper (14) by Wakefield, Ashwood et al was published, assessing ileocolonic lymphoid nodular hyperplasia in ASD and normal control children. Some 148 consecutive children with ASD, with gastrointestinal symptoms, were investigated by ileocolonoscopy, with 74 ASD children and 23 normal controls undergoing upper gastrointestinal endoscopy. The presence of lymphoid nodular hyperplasia was significantly greater in ASD children compared with controls, in the ileum (129 out of 144, compared with 8 out of 27 controls), and in the colon (88 out of 148, compared with 7 out of 30 controls). Comparative percentages were 90% vs 30% and 59% vs 23%. This was whether or not controls had co-existent colonic inflammation. The severity of ILNH was significantly greater in ASD children compared with controls, with moderate-to-severe ILNH present in 98 out of 144 ASD children compared with 4 out of 27 controls; percentages were 68% and 15%. On histopathological examination, hyperplasic lymphoid follicles were significantly more prevalent in the ileum of ASD children (84 out of 138, or 61%) compared with normal controls (2 out of 23, or 9%). The data thus further corroborated the finding that ileal lymphoid nodular hyperplasia is a significant pathological finding in autistic children.

• Additionally in 2005, a study (15) was published by Gonzalez, Lopez et al , seeking evidence of immunological alterations in 68 autistic children ages 22 months to 11 years and presenting with digestive systems, and examining biopsies from their digestive tracts. Endoscopies and colosopies were undertaken, with biopsies of the esophagus, stomach, duodenum and colon, with verification of presence of inflammation, eosiophil infiltration, lymphoid nodular hyperplasia and CD-4 and CD-8 cells. The results were that lymphoid nodular hyperplasia was discovered in 2/68 esophagus, 6/68 stomachs, 8/68 duodenums and 36/68 (53%) of colons. Eosiophil infiltration with more than 20 eosiphils per field were found in 3/68 eosphagus, 1/68 stomach, 8/68 duodenum and 24/68 (35%) colons. Inflammatory reactions were found in 56/68 (82%) esophogitis, 64/68 (94%) gastritis, and all (100%) presented with duodenitis and colitis. CD-4/CD-8 relationship existed of >3 in 42/68 (62%) and <1 in 16/68. The authors concluded that the children presented immunological and immunohistochemical alterations of the biopsies of their digestive tracts, and that there was a significant finding of lymphoid nodular hyperplasia, eosiophilinfiltration, and that prevalence of greater CD-4 than CD-8 cells in the inflammation of the intestinal wall demonstrated in favour of a Th2 type allergic reaction.

Taken together, the above now provide very convincing evidence from a number of wholly-independent groups of researchers of a link between the novel inflammatory bowel disease of ileal lymphoid nodular hyperplasia and regressive autism.

(B) The Link Between Inflammatory Bowel Disease and Measles Virus

These autism/inflammatory bowel disease findings were followed by findings that linked the novel form of inflammatory bowel disease with persistent measles virus in the gut of affected children:
• A paper (16) by Uhlmann, Sheils et al , noting that measles virus nucleoprotein (N antigen) had been detected in association with follicular dendritic cells (FDC) in patients, and seeking molecular confirmation of this result, found that :solution phase RT PCR yielded specific measles virus N gene amplification in affected children (10/10), and identified distinct measles virus genome in FDC reactive follicular centres by in-cell RNA amplification. None of the normal controls showed any evidence of measles virus genome. The data highlighted a possible causal link between measles virus infection and ileo-colonic lymphoid nodular hyperplasia in affected children.

• A paper (17) presented in the year 2000 by Singh to the US House of Representatives Committee on Government Reform reported a hyperimmune response to the measles virus, with an association between measles virus antibody levels and incidence of brain autoantibody.

• An April 2000 paper (18) presented by O'Leary to the Committee on Government Reform reported the investigation whether measles virus was present n the gut biopsies of autistic children, and if so, where and how much. The paper reported that the biopsies of 24 out of 25 (96%) of the autistic children examined were positive for measles virus, and that amongst normal (non-autistic) controls, only 1 out of 15 children (6.6%) were positive, strongly suggesting a connection between measles virus and autism.

• A February 2002 paper (19) by Uhlmann, Wakefield, O'Leary et al investigated the presence of persistent measles virus in the intestinal tissue of 91 autistic patients with new-variant inflammatory bowel disease (ileal-lymphoid nodular hyperplasia, or ILNH). Patient samples were provided by the Royal Free Hospital, London. The patients were ages 3-14, and 77 out of 91 were male. There were 70 developmentally-normal controls ages 0-17 years, 47 out of 70 being boys. Of these, 19 had normal ileal biopsies, 13 had mild non-specific chronic inflammatory changes, 3 had ILNH and had been investigated for abdominal pain, 8 had Crohn's Disease, one had ulcerative colitis, and 26 had undergone appendicectomy for abdominal pain including appendicitis. The results were that 75 out of 91 patients with a histologically-confirmed diagnosis of ileal-lymphoid nodular hyperplasia and enterocolitis were positive for measles virus in their intestinal tissue, compared with 5 out of 70 controls. Using TaqMan RT-PCR techniques, 70 out of 91 affected children were positive for measles virus, compared with 4 out of 70 controls. Of the controls, measles virus was not detected in normal children or children with isolated ileal-lymphoid nodular hyperplasia. However, 4 out of 26 appendicectomy samples harboured measles virus genome; the study suggested that the prevalence of measles virus in the general population warranted further investigation. The study concluded that the data confirmed an association between the presence of gut pathology and of measles virus in children with developmental disorder. The study did not exclude the presence of alternative infections to measles virus.

• A February 2004 paper (20) presented by Singh to the US Institute of Medicine, Washington DC, measured antibodies in autistic children to five viruses, measles, mumps, rubella, CMV and human herpes virus 6. Researchers found that the antibody level of the measles virus alone, and not the other four, was significantly higher in autistic children than in normal children. The research also found a correlation between measles antibody and brain autoimmunity, which was marked by myelin basic protein antibodies. The two markers correlated in over 90% of the autistic children tested for them, suggesting a causal link between measles virus and autoimmunity in autism. The serology to other viruses and other brain autoantibodies did not show this correlation. This suggested a temporal link of measles virus in the etiology of autism.

An early-report presentation by Walker, Hepner et al , at the International Meeting for Autism Research, Montreal, June 2006, reported that PCR analysis on terminal ileum biopsy tissue from an initial 82 patients found 70 (85%) positive for measles virus f-gene amplicon. These preliminary results confirm earlier findings of measles virus RNA in the terminal ileum. Full publication of this study is anticipated.

The above studies provide significant evidence for a link between measles virus and ileal lymphoid nodular hyperplasia, with the latter's earlier-demonstrated onward link with regressive autism.

(C) The Link Between Measles Virus and Vaccination with MMR
• A July 2002 paper (21) presented by O'Leary reported that the strain of measles virus used in MMR had been detected in the gut tissue of 12 autistic children. Medical histories had indicated that each of the children had developed autism after the date of receipt of MMR, and none had exhibited outward signs of measles infection before becoming autistic.

• An April 2000 study (22) by Kawashima, Takayuki et al confirmed that, amongst 8 patients with Crohn's Disease, 3 patients with ulcerative colitis and 9 patients with autistic enterocolitis, and 8 children who were either healthy or who had SSPE, SLE or HIV-1, 1 out of 8 patients with CD, 1 out of 3 patients with UC and 3 out of 9 patients with autism were positive for measles virus. Controls were all negative. The sequences from patients with CD shared the characteristics of wild-strain measles virus. The sequences from patients with UC and from patients with autism were consistent with vaccine strain measles virus. These results were consistent with patients' medical histories, and point to a connection between autism and vaccine-strain measles virus.

• A May 2002 paper (23) by Singh, Nelson, Jensen and Bradstreet found that a significant percentage of autistic children examined had antibodies to myelin basic protein (up to 88% positive) and to MMR (up to 65% positive). Normal children did not exhibit these antibodies. The analysis of paired samples (serum and cerebral spinal fluid from 7 autistic children also revealed a high degree of serological association between MMR and myelin basic protein. Some 50% of CSF had MMR antibodies, 86% of CSF had MBP antibodies, 75% of sera had MMR antibodies and 100% of sera had MBP antibodies. Therefore there was a strong correlation between MMR antibodies and myelin basic protein antibodies. By using monoclonal antibodies, the authors characterized that the MMR antibodies were due to the measles sub-unit, but not to the mumps or rubella sub-units, of MMR. In the light of this, the authors suggested that in some cases of autism, MMR might cause autoimmunity, and it might be doing so by bringing on an atypical measles infection that manifests neurological symptoms.

• An earlier 1999 paper (24) by Bitnun has previously and independently confirmed the presence of measles virus in the brain tissue of a previously-healthy child following exposure to MMR, when the child had no history of wild measles infection.

• A February 2004 paper (25) by Bradstreet, O'Leary, Sheils et al to the US Institute of Medicine, and subsequently published later that year, reported that three children with regressive autism had undergone cerebrospinal fluid assessment, including for measles virus. All three had had concomitant onset of gastrointestinal symptoms and had already had measles virus genomic RNA detected in biopsies of ileal-lymphoid nodular hyperplasia. None of the cases nor non-autistic controls had any history of measles exposure other than possibly via MMR. Serum and cerebrospinal fluid samples were also evaluated for antibodies to measles virus and myelin basic protein. The result was that measles virus f-gene was present in the cerebrospinal fluid of all three autistic cases but not in non-autistic controls. Further, serum anti-myelin basic protein autoantibodies were detected in all children with autistic encephalopathy. Anti-MBP and measles virus antibodies were detected in the CSF of two cases, but the third had neither. The study concluded that the findings were consistent with a measles-virus etiology for autistic encephalopathy, indicating the possibility of a virally-driven cerebral immunopathology in some cases of regressive autism. The virus genome found in the autistic children was “exclusively consistent with vaccine strain”.

• A May 2006 study (26) by Wakefield, Stott and Limb investigated the hypothesis as to whether a dose-response effect of measles-containing vaccine on intestinal pathology existed. If it did exist, this would constitute evidence of a causal association. In the study, children with normal early development and autistic-like developmental regression were divided into two groups. Children were divided into two groups: some 23 re-exposed children, i.e. those who had received more than one dose of a measles-containing vaccine (MCV), and 23 children who had received only one dose of MCV. The groups were matched for sex, age and time that had elapsed from first exposure to time of endoscopy. Comparisons made included secondary gastrointestinal (GI) and related physical symptoms, and “observer-blinded” scores of endoscopic and histological disease. The results were that re-exposed children scored significantly higher than only-once-exposed for secondary physical symptoms, including incontinence, presence of severe ileal-lymphoid nodular hyperplasia, the number of biopsies with epithelial damage, and number of children with acute inflammation. Markers of acute inflammation include number of children affected, and proportion of biopsies affect. The conclusion of the study was that the data confirmed a re-challenge effect (i.e. a double-hit effect) of measles-containing vaccines on symptoms, and also confirmed a biological gradient effect upon intestinal pathology. These findings thus link exposure to measles-containing vaccines to autistic-like regression and enterocolitis. (Note: it was stated in April 2001 by the Vaccine Safety Committee of the US Institute of Medicine that in the context of MMR and autism “challenge re-challenge would constitute strong evidence of an association”.)

Taken together, with the Walker, Hepner et al study, the above points to MMR as the means by which measles virus enters and persists in the gut, leading to ileal-lymphoid nodular hyperplasia, and in turn leading to regressive autism. The evidence to fully explain the complete causational mechanism by which this occurs is still emerging, and clearly requires further urgent research.

The intestinal disease has the features of a viral disease. Measles virus is known to infect the intestine, and produces the features described originally by Wakefield and colleagues in 1998.

All the findings described in the 1998 Lancet report by the Wakefield team - including the discovery of a possible new type of inflammatory bowel disease, have therefore been subsequently independently confirmed by other researchers in the US, in Italy and in Venezuela.

The studies suggest that in some children, brain damage leading to autism may be secondary to, or occur in parallel with, a disease in the intestine, and that vaccine strain measles virus has become the prime suspect in this complex investigation.

The findings to date have important implications for our understanding and treatment of the complex disorder of regressive autism.

(D) Wider Safety Concerns Over MMR:

It is also instructive to examine the original, and any subsequent, safety studies of MMR.
• An authoritative independent review by the Cochrane Collaboration (27) of the safety studies of MMR vaccine concluded that “the design and reporting of safety outcomes in MMR vaccine studies, both pre- and post-marketing, are largely inadequate”. It further confirmed that neither before nor after the introduction of the MMR vaccine were proper safety trials carried out.

• A more recent review (28) from the same organization identified that safety studies for the single measles vaccine were better than those conducted for MMR: “We found only limited evidence of safety of MMR compared to the single component vaccines, that had a low risk of bias”. The authors of the Cochrane reviews were highly critical of the safety studies of MMR, which they stated “need to be improved”. Cochrane mentioned a specific concern that safety studies followed up the children involved for no more than three weeks, except for one study that lasted just six weeks.

• Concern over MMR's safety has been expressed (29) by a key former scientific adviser to the UK licensing authorities. Dr. Peter Fletcher , former Principal Medical Officer in the (then) UK Medicines Division, who was medical assessor to the Committee on Safety of Medicines, commented: “Evidence on safety was very thin” , and “Too few children were followed for a sufficient time... Big numbers were necessary, and computerised databases were already in place to permit this, but it was not done... Caution should have ruled the day... There should have been strong encouragement to conduct a 12-month observational study on 10,000-15,000 children...” (this was not done) "The granting of a product licence was premature.”

• A year-2000 review (30 by Wakefield & Montgomery examined early safety studies of MMR, by Buynak et al 1969, Stokes et al 1971, Minekawa et al 1974, Schwartz et al 1975, Crawford and Gremillion 1981, and Miller et al 1987. The Buynak study identified viral “interference”, but the follow-up period was only 12 days. The Stokes study revealed persistent gastrointestinal problems in the US trial children, but the follow-up was only 28 days. Stokes compared 228 MMR children with 106 unvaccinated controls. Data, from Philadelphia and Costa Rica and San Salvador, was merged - a major methodological error. Gastroenteritis was found to be significantly more common in the Philadelphia vaccines (24%) compared with the unvaccinated Philadelphia controls (5.6%). No significant difference was found between the vaccinated and the unvaccinated in Costa Rica and San Salvador because of high ambient levels of gastroenteritis anyway (50% in vaccines, 44% in controls). Combining all the data masked these instructive differences. There was also significant “unrelated” illness in 39% of Philadelphia vaccines (otitis, allergy, viral infection, abdominal pain), compared with 12.2% in controls. The potential relevance of this was not seen at time. The Minekawa study confirmed viral interference. The follow-up period was only 15 days. The Schwartz study also merged its data, so provided insufficient insight, and again follow-up was only 21 days. The study looked at two different populations, 282 children in Ohio and 926 children in Santo Domingo, Dominican Republic. Again, the merging of data from different countries was a serious error. No data was provided to permit analysis of adverse events. Crawford and Gremillion's study of USAF recruits confirmed viral interference, but the follow-up period was only 19 days. Some 512 vaccines were compared with 835 unvaccinated controls. The study noted increased fever and diarrhoea in those that received measles and rubella vaccines simultaneously. But the potential effect of trivalent vaccine was only seen as additive instead of potentially synergistic - a key point. The Eddes study (a small UK study) in 1991 compared reactions to MMR with monovalent measles vaccine. High rates of gastrointestinal disorders (41.9% and 37.8%) were found, but the authors dismissed these as normal background illness. The Dr. Elizabeth Miller study noted that diarrhoea was common (26% of vaccinees), but the follow-up again was only 21 days. This was a major missed opportunity to follow up a large cohort. The Stokes, Schwartz, Miller and Eddes studies were therefore all too small or too superficial to pick up uncommon adverse events. The Plesner et al study of gait disturbance following MMR ( Acta Paediatrica , 2000, 89, 58-63) confirmed an association, and indicated that more severe cerebellar ataxias following MMR may be associated with residual cognitive deficits.

Cochrane was forced to conclude that “the safety record of MMR is probably best attested by its almost universal use.” Or to put it another way, “the best evidence of MMR's safety we can find is that fact that it's being widely used” - hardly a scientific test of a product's actual safety, particularly when the evidence of problems is through a hitherto-unsuspected link between MMR and autism, that would not have been monitored prior to 1998.

References

( on the link between autism and a novel form of inflammatory bowel disease )

(1) Wakefield et al, Inflammatory Bowel Disease Study Group, Royal Free Hospital London, Ileal Lymphoid Nodular Hyperplasia, Non Specific Colitis and Pervasive Development Disorder in Children , Lancet, 28th February 1998

(2) Horvath, Papadimitiou et al, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, Gastrointestinal Abnormalities in Children With Autistic Disorder , Journal of Pediatrics, 1999 November, Vol 135 (5), pp559-563

(3) Wakefield, Anthony et al, Enterocolitis in Children with Developmental Disorders , American Journal of Gastroenterology, Sept 2000, Vol 95, No. 9, pp2285-2295

(4) Furlano, Anthony et al, Colonic CD8 and T-Cell Infiltration With Epithelial Damage in Children with Autism , Journal of Pediatrics, 2001; 138; No. 3, 366-372

(5) Paper by Dr. Timothy Buie, Harvard Massachusetts General Hospital, presented to the Oasis 2001 Conference for Autism, Portland, Oregon, November 2001

(6) Wakefield, Anthony, Montgomery et al, Inflammatory Bowel disease Study Group, Royal Free Hospital, University College Medical School, London, and Coombe Women's Hospital and Trinity College Dublin, The Concept of Enterocolonic Encepalopathy, Autism and Opioid Receptor Ligands , Aliment Pharmacological Ther, 16: pp663-674

(7) Presentation by Krigsman to the US Congressional Committee on Government Reform's June 2002 hearing, The Status of Research into Vaccine Safety and Autism, held in Washington DC

(8) Ashwood, Murch et al, Royal Free Hospital, London, Intestinal Lymphocyte Populations in Children with Regressive Autism: Evidence for Extensive Mucosal Immunopathology , Journal of Clinical Immunology, Vol 23 No. 6 Nov 2003 pp504-517

(9) Torrente, Anthony et al, Centre for Pediatric Gastroenterology, Royal Free Hospital and University College Medical School, London, Focal-Enhanced Gastritis in Regressive Autism, With Features Distinct from Crohn's and Helicobacter Pylori Gastritis , American Journal of Gastroenterology, Vol 99, Issue 4, p598, April 2004

(10) Ashwood, Anthony et al, Spontaneous Mucosal Lymphocyte Cytokine Profiles in Children with Autism and Gastrointestinal Symptoms: Mucosal Immune Activation and Reduced Counter-Regulatory Interleukin-10 , Journal of Clinical Immunology, Vol 24, No. 6, November 2004

(11) Jyonouchi, Geng et al, Department of Pediatrics, New Jersey Medical School, Dysregulated Innate Immune Responses in Young Children with Autistic Spectrum Disorders - Their Relationship in Gastrointestinal Symptoms and Dietary Intervention , Neuropsychobiology, February 2005, 51 (2) pp77-85

(12) Letter by Balzola, Barbon et al, Department of Gastroenterology, Department of Neuropsychiatry for Children, Department of Pediatric Gastroenterology and Department of Biomedical Sciences and Human Oncology, University of Turin, Pan-Enteric IBD-Like Disease in a Patient with Regressive Autism Shown for the First Time by the Wireless Capsule Enteroscopy - Another Piece in the Jigsaw of this Gut/Brain Syndrome? , American Journal of Gastroenterology, 2005; 100 (4) p979

(13) Balzola, Daniela et al, Department of Gastroenterology, Department of Neuropsychiatry for Children, Department of Pediatric Gastroenterology and Department of Biomedical Science and Human Oncology, University of Turin, Autistic Enterocolitis - Autistic Enterocolitis: Confirmation of a New Inflammatory Bowel Disease in an Italian Cohort of Patients , paper presented to the American Gastroenterological Association, May 2005 and published in Gastroenterology 2005: 128 Suppl 2, A-303

(14) Wakefield, Ashwood et al, The Significance of Ileo-Colonic Lymphoid Nodular Hyperplasia in Children with Autistic Spectrum Disorder , European Journal of Gastroenterology and Hepatology, 2005, Vol 17 No. 8

(15) Gonzalez, Lopez et al, Endoscopic and Histological Characteristics of the Digestive Mucosa in Autistic Children with Gastrointestinal Symptoms: Preliminary Report , G.E.N. Suplemento Especial de Pediatria, no. 1, 2005; pp41-47


( on the link between inflammatory bowel disease and measles virus )

(16) Uhlmann, Sheils et al, Department of Pathology, Coombe Women's Hospital Dublin, Trinity College Dublin and Royal Free Hospital London, Measles Virus in Reactive Lympho-Nodular Hyperplasia and Ileo-colitis of Children

(17) Paper presented by Dr. Vijendra Singh, University of Michigan College of Pharmacy, to the US House of Representatives Committee on Government Reform, Washington DC, 2000

(18) Paper presented by Professor John O'Leary, Dublin Women's Hospital, to the US House of Representatives Committee on Government Reform, Washington DC, April 2000

(19) Paper By Uhlmann, Wakefield, O'Leary et al, Potential Viral Pathogenic Mechanism For New Variant Inflammatory Bowel Disease , Journal of Clinical Pathology, Molecular Pathology, 2002, 55, 0-6, published 6th February 2002

(20) Paper by Singh, Department of Biology Center for Integrated Biosystems, Utah State University, Logan, Autism, Vaccines and Immune Reactions , presented to the Institute of Medicine, Washington DC, February 2004


( on the link between measles virus and vaccination with MMR )

(21) Paper presented by O'Leary, Coombe Women's Hospital and Trinity College Dublin to the Pathological Society of Great Britain and Ireland, July 2002

(22) Kawashima, Takayuki et al, Detection and Sequencing of Measles Virus from Peripheral Mononuclear Cells from Patients with Inflammatory Bowel Disease and Autism , Digestive Diseases & Science, Vol 45, No. 4, April 2000, pp723-729

(23) Singh, Nelson, Jensen and Bradstreet, Abnormal Measles Serology and Autoimmunity in Autistic Children , Journal of Allergy and Clinical Immunology 109 (1) S232, January 2002, and also presented to the 102nd General Meeting of the American Society for Microbiology, Salt Lake City, Utah, May 2002

(24) Bitnun et al, Measles Inclusion-Body Encephalitis Caused by the Vaccine Strain of Measles Virus , Clinical Infectious Diseases Journal, 1999, 29 855-61 (October)

(25) Bradstreet, O'Leary, Sheils et al, Detection of Measles Virus Genomic RNA in Cerebrospinal Fluid in Children with Regressive Autism by TaqMan RT-PCR: A Report of Three Cases , summarized at the Institute of Medicine, February 2004 and subsequently published as Bradstreet, Dahr et al, Detection of Measles Virus Genomic RNA in Cerebrospinal Fluid of Children with Regressive Autism: A Report of Three Cases , Journal of American Physicians and Surgeons, Vol 9, No. 2 Summer 2004

(26) Wakefield, Stott and Limb, Gastrointestinal Comorbidity, Autistic Regression and Measles-Containing Vaccines; Positive Re-challenge and Biological Gradient , Medical Veritas 3 (2006) 796-802

Again, taken with the latest study by Walker, Hepner et al, this now provides evidence that it is highly likely that MMR vaccine is the source of the measles virus that is in turn linked via significant evidence with ileal lymphoid nodular hyperplasia, which in turn is strongly and convincingly linked with regressive autism.

( on wider safety concerns over MMR vaccine )

(27) Jefferson, Price et al, Unintended Events Following Immunisation with MMR; A Systematic Review , Vaccine, 2003; 21: pp3954-3960

(28) Demicheli, Jefferson et al, Vaccine For Measles, Mumps and Rubella in Children (Review) , The Cochrane Collaboration, published Wiley & Sons, UK, from The Cochrane Library, 2005, Issue 4, art. No. CD004407

(29) Commentary by Dr. Peter Fletcher, Journal of Adverse Drug Reactions & Toxicology, 2001, 20 (1), 47 63 Oxford University

(30) Wakefield & Montgomery Through A Glass Darkly (A Look Back At MMR's Safety Trials), Journal of Adverse Drug Reactions, 2000 19(4), 265-283

truthout

lilady you say people who chelate are child abusers.

On the CDC web site it states " if you get to much Mercury, it is necessary to chelate "


The founder of Autism Speaks grandson, christian could not speak. He starts chelation and
he begins to speak again. That's his mothers words, in an interview.

If they had not chelated the children from the 1900's to 1950's with pinks they would have died with pinks. They had Mercury poisoning, coming from the teething powders.

The product used to chelate pinks, was as Trine said an industrial compound.

That's the same words Trine used to describe OSR #2 a Industrial compound.

This FDA email was a FOIA email "were afraid the public will perceive us asleep at the switch for decades,for allowing this dangerous compound to remain in the vaccines"

Shouldn't Trine write about the FDA, allowing a dangerous compound to remain in the vaccines for children for Decades.

You really don't know anything about this, issue do you?

lilady

truthout: Get yourself some help. You've had and continue to have delusional hallucinations.

Stop abusing your child...you've already harmed your. If you have religious faith speak to someone to confess your sins for having abused your child

truthout

Watch this video, there is a surprise at the very end and it is totally awesome.

http://www.youtube.com/watch?v=qDjiUvVbzNg&feature=related

Now after you watch this, think about the one who put that in the heavens for all to see forever as a testament to what he did, just for you.

lilady

You're not on a religion blog truthout. Try to stay on topic and stop posting religious song videos.

ASD Researcher

Dear Matt Carey

First to your questions - "Who is we".

Simply the general public , some but not all members of the autism community and at a more personal level my family and I.

"Do you represent Prof. John Walker-Smith and/or Prof. Murch?"

I have represented their 'side' and supported both Professors in public and private many many times.

I have also asked the same questions to the General Medical Council and the British Medical Journal.

"Who are you to ask for an apology as "we"?"

A father, a member of the autism community, a member of the general public and a social justice advocate for those voices that are disenfranchised from this debate.

If you wish to discuss Andrew Wakefield then you'll have to address the issues surrounding Professor John Walker-Smith and Professor Simon Murch first.

The UK High Court decision is linked below.

http://www.bailii.org/ew/cases/EWHC/Admin/2012/503.html

regards

* Dad with an autisitic son who is fully vaccinated on time and schedule as is the rest of his family. I have never 'blamed' vaccines for my son's condition.

Science Mom

"I have represented their 'side' and supported both Professors in public and private many many times.

I have also asked the same questions to the General Medical Council and the British Medical Journal."

You don't really understand what the bar is for "represents" do you? Fawning over some people you really like and writing creepy letters to organisations doesn't elevate you to the status of demanding anything from anybody. You've misrepresented yourself too many times for that anyhow.

ASD Researcher

I see nothing untoward in advocating for social justice, particularly in areas of disability and ethics.

More often than not those who live in the wider disabilities communities do not have a voice to express their concerns to those in public offices and business. That was just one issue at hand.

Intelligent and critical community members recognise that issues often portrayed in the media are usually only representative of one side, advocating and showing another side , in this case the personal and professional honesty of two professors of paediatric gastroeneterology is not 'fawning' but the modelling of a more balanced ethical approach to sometimes 'controversial issues.

As to the charge of misrepresenting myself I no longer take much note of how conclusions on my personal or professional life came about. Except to say that they are in error ... but you remain obviously in the dark as to why because you make assumptions before you think and reflect.

Science Mom

Two professors? No, you are a Wakefield apologist who is co-opting the situations of his co-defendants. You are trying to create false-balance. There is no longer any controversy regarding Wakefield, Walker-Smith and Murch. There was once but the matter has been settled and those deserving, vindicated.

Of course you wouldn't want to take note of my charges of your misrepresenting yourself. You are not an "ASD researcher"; you have never published nor collaborated with any ASD scientists. Googling abstracts and posting link dumps and inane associations between legitimate research scientists and your raison d'etre Wakefield does not make you a researcher. That is a privilege that is earned through requisite education and well, actually conducting research. And for that you should be ashamed of yourself and sounds like you are but not enough to admit your wrong-doing and cease from continuing.

ASD Researcher

Dear Matt Carey

If what you say is true when can we expect a full and unconditional and sincere apologies in regards to Professor John Walker-Smith and Professor Simon Murch.

When can we expect a clear, unconditional, acknowledgement that both those doctors acted at all times professionally and ethically and treated severely disabled children with the requisite care and compassion.

When can we expect an unconditional apology to the parents in the recognition that their children were suffering serious bowel and GI conditions and that their actions in seeking medical assistance from paediatric gastroenterologists was both right and proper. Whether or not they associated a link to MMR.

When can we expect an acknowledgement that the observations of Professor John Walker-Smith and Professor Simon Murch made and published in regards to inflammatory changes (colitis) in autistic children were given honestly and professionally based on their skill and expertise as leading and eminent paediatric gastroenterologists.

When can we expect a clear acknowledgment that 'regression' in autistic children with severe bowel disease / disorders is a real medical condition as confirmed independently by paediatric gastroenterologists working in other research institutions notably Columbia University, New York.

regards

Dad with an Autistic son

Matt Carey

"If what you say is true when can we expect a full and unconditional and sincere apologies in regards to Professor John Walker-Smith and Professor Simon Murch."

Who is "we"? Do you represent Prof. John Walker-Smith and/or Prof. Murch? Who are you to ask for an apology as "we"?

Given the subject at hand--when can we, the autism community, expect an apology from Andrew Wakefield? I'm not enough of an optimist to expect Mr. Wakefield to step up to accept responsibility for his actions. Too much data shows that Mr. Wakefield will blame others for his own failings. Honesty seems a foreign concept to the man, both in his research and in his public discourse. I'd have more respect for him if he was simply wrong. People make mistakes. Even big ones. He didn't. Mr. Wakefield has been shown to be unethical.

I have an autistic child as well. My child and I deserve an apology from Mr. Wakefield. I have the standing to make that request. Mr. Wakefield has caused a great deal of effort and money to be diverted into nonproductive paths.

Twyla

Dr. Wakefield does not owe anyone an apology. A whole lot of people owe him a huge apology, including the GMC, and the mass media who have parroted the stories about him without any independent thinking whatsoever.

Matt Carey

"Two of the most prominent figures in the debate over whether vaccines contribute to autism are coming to La Crosse."

You mischaracterize the discussion in so many ways in your first sentence.

Mr. Deer's work is not about the "vaccine-autism debate", but about the unethical actions Mr. Wakefield took in his research.

There is no real "debate" about Mr. Wakefield's hypothesis on MMR and autism. Mr. Wakefield was wrong. Even his colleague, John Walker-Smith, made that clear in his appeal to regain his license. Whatever "debate" there was about Mr. Wakefield's ideas, they were held where they should have been held--in the scientific literature.

Mr. Wakefield was basically a mediocrity who ran with a bad idea and hasn't had the good sense to accept the facts that have been repeatedly put before him. His relevance to the real world of autism ended a long time ago.

lilady

There no longer is a "debate" about the triple antigen MMR vaccine...or any other vaccine causing autism. That debate ended when most of the co-authors of his "study" disavowed the study. Multiple studies conducted since the publication of his "study" in the Lancet, have been unable to reproduce the conclusions of Wakefield's study (the presence of vaccine measles strain within the digestive tract), which he based his "syndrome" of autistic enterocolitis on. The Lancet Journal editors were *remiss* when they delayed the retraction of the Wakefield study.

While promoting Wakefield as their "hero" at Age of Autism, the editors and the "journalists" at that website have repeatedly and viciously libeled and slandered Mr. Deer.

"Mr. Wakefield was basically a mediocrity who ran with a bad idea and hasn't had the good sense to accept the facts that have been repeatedly put before him. His relevance to the real world of autism ended a long time ago."

So too, has the relevance of Age of Autism to the real world of autism, ended a long time ago.


skeptic

Science Mom and all other vaccine promoters: If you insists that vaccines are safe and thoroughly tested, how do you explain that Gardasil was tested with the aluminum adjuvant as the "placebo"? The RotaTeq was safety tested with "a bioactive placebo". What a joke! Merck is being sued for falsifying efficacy data for the MMR. The only way you can defend any of this if you are intellectually dishonest or an idiot. Just keep drinking the Kool-Aid!

UW-L would better educate themselves on how vaccines are made, tested and marketed. They could learn a lot!

lilady

Skeptic: Do try to stay on topic. The topic of this thread is the upcoming Brian Deer seminars at UW-L. The seminars will be instructive for science students and journalism students to learn how to properly investigate bad scientific studies.

Your hero the disgraced and delicensed Andrew Wakefield has decided to conduct a press conference nearby. He's reduced himself to a carney barker and all the clowns from the AoA, from the Canary Party and other cranks will be there to see the sideshow.

We are not posting here to instruct you how vaccines are tested during Phase II doubled-blinded placebo-controlled trials.

We have all read the legal papers and the allegations of supposed "whistleblowers" (former employees of Merck) who "alleged" falsification of data. The case has not been adjudicated. IMHO, that case hasn't a prayer of succeeding; it will be "tossed".

Matt Carey

There are people at the U who understand far better than you about vaccines.

lilady

My last comment about Trine Tsouderos should have been directed to truthout.

@ trouthout: Here's another link to Trine Tsouderos, at the Chicago Tribune. It is an on-line interactive discussion about vaccines, vaccine safety and vaccine-preventable diseases (March, 2011), with Dr. Paul Offit and with others who submitted comments to Ms. Tsouderos and Dr. Offit:

http://www.chicagotribune.com/health/ct-health-chat-vaccines,0,7750657.htmlstory

truthout

Either she is being paid big bucks, or the paper she works for is. Not sure which,
but as God is my witness she told me where to get OSR #2 she said that they had
not stopped selling it yet.

If you can understand why someone would write a story about the EVILS of OSR #2
and then clue you in on where you can still get it. Is she is just doing her job, to
keep from losing her job...

That's all I know.

Science Mom

You can't denigrate her so you have to try and make her look like a dupe? Novel approach but deluded. Ms. Tsouderos never spoke with you about the DoJ nor where to get OSR. How pathetic.

truthout

You evidently, have a hard time reading and comprehending. What you read I never once said she spoke to me about the DOJ that was my comparison to what
she has done. Attacking something, that she is not qualified to even speak on.

Did she tell me where to get OSR # 2 after her article? Yes

Science Mom

"Just as it has been found out recently, that those working for the justice department on the fast and furious scandal. Were feeding information ( propaganda ) to a so called journalist
they wanted the public to be brain washed. to believe what they want.

Trine Tsouderos, Chicago Tribune person was used in the same manner, to get OSR #2
off the market. I contacted Trine and shared how my son was getting help by Dr. Boyd Haleys oxidative stress remover. And I was angry she was used by the FDA to get it
off the market. She Trine, suggested to me a place she knew that was still selling it."

Your words truthout. And I know you are full of it because no one, particularly the DoJ and FDA have to "use" journalists to pull an unsafe product off the market. You didn't speak to her and she certainly didn't tell you where to get OSR so you could keep chelating your child. Anti-vaxxers resorting to lies and misrepresentation; I'm shocked I tell you.

Science Mom

Blackheart/JRS you are clearly plumbing the depths to exonerate your idol Wakefield. First, of course the medical establishment had a hand in it, what do you think the GMC is and does? You also fail to mention Dr. Murdoch, why wasn't he found guilty of any charges in the GMC FTP proceeding. Using paranoid screeds as your evidence is consistent though.

lilady

Just a small correction Science Mom. I think you are referring to Dr. Simon Murch, who was NOT the principal investigator of the Wakefield "study"

Here's a blog from LB/RB (no I am not the LB/RB blogger), about the GMC Dr. Murch FTP hearing:

http://leftbrainrightbrain.co.uk/2010/05/24/dr-simon-murch-and-the-gmr-free-to-continue-unrestricted-medical-practice/

I suggest that Black/JRS read the LB/RB blog...here too, Murch's testimony and the evidence entered into the FTP hearing on his behalf...adds additional information about Wakefield's guilt.

Science Mom

Yes, thank you lilady. I meant Dr. Murch. Funny how he is never mentioned by the Wakefield fanclub.

ASD Researcher

Sorry Science Mom it's not my opinion alone it is also the frank opinion of Doctor James LeFanu ...

James Le Fanu is a Doctor, columnist, social commentator and historian of science and medicine. He was born in 1950 and spent his childhood in Scotland, East Africa, Yugoslavia and Cyprus. He studied the humanities at Ampleforth College before switching to medicine, graduating from Cambridge University and the Royal London Hospital in 1974. He subsequently worked in the Renal Transplant Unit at Cardiology Departments of the Royal Free and St Mary’s Hospital in London.

For the past twenty years he has combined medical practice with writing a twice weekly column for the Sunday and Daily Telegraph as well as contributing reviews and articles to The Times, Spectator, Prospect, The Oldie, The British Medical Journal and Journal of the Royal Society of Medicine.

His (much acclaimed) ‘The Rise and Fall of Modern Medicine’ charts the change in fortunes of medicine over the past sixty years from the supreme achievements of its ‘Twelve Definitive Moments’ to its current discontents. His most recent book ‘Why Us?: How Science Rediscovered the Mystery of Ourselves’ investigates the paradox where the major developments in genetics (including the Human Genome Project) and neuroscience of the past two decades have inadvertently revealed the limits of an exclusively scientific account of the form and attributes of the living world and the exceptionality of the human mind.

He has in addition made original contributions to controversies over human embryo experiments, the social and environmental causes of illness and ‘Shaken Baby Syndrome’. He is married to the publisher Judith Annan, has two children Frederick and Allegra and lives in South London.

Science Mom

Whoop de doo; it's his opinion pure and simple and was even written before Walker-Smith's appeal. Fawn over him all you like; I'm remarkably under-whelmed.

ASD Researcher

I wonder how people weigh your opinion on these issues ?

Luckily the ever erudite Le Fanu was proven true and correct. More depth to this story than meets the eye.

No surprise there.

lilady

@ ASD Researcher:

Are you now stating that you have a conversation with Trine Tsouderos and SHE was upset that she was being "used" by the DOJ?

"Just as it has been found out recently, that those working for the justice department on the fast and furious scandal. Were feeding information ( propaganda ) to a so called journalist
they wanted the public to be brain washed. to believe what they want.

Trine Tsouderos, Chicago Tribune person was used in the same manner, to get OSR #2
off the market. I contacted Trine and shared how my son was getting help by Dr. Boyd Haleys oxidative stress remover. And I was angry she was used by the FDA to get it
off the market. She Trine, suggested to me a place she knew that was still selling it.

I"m stunned, she was used to get it removed from the market. And now, she is telling me where to buy it.??????????? WT frick is going on, I am thinking."

And...I am thinking you are delusional and a liar, as well.

ASD Researcher

lilady

Normally I ignore your rather interesting commentary but this caught my eye ...

"And...I am thinking you are delusional and a liar, as well."

Wrong person.

Cheers

truthout

lilady I am no anti vaccine spammer, I am the dad, of a very sick child that was destroyed
by his vaccines.

lilady you brought up Trine Tsouderos and said I can't believe you are touting and quoting Boyd Haley. Here's an article about Boyd Haley written by Trine Tsouderos, a real science journalist, that appeared in the Chicago Tribune:

Just as it has been found out recently, that those working for the justice department on the fast and furious scandal. Were feeding information ( propaganda ) to a so called journalist
they wanted the public to be brain washed. to believe what they want.

Trine Tsouderos, Chicago Tribune person was used in the same manner, to get OSR #2
off the market. I contacted Trine and shared how my son was getting help by Dr. Boyd Haleys oxidative stress remover. And I was angry she was used by the FDA to get it
off the market. She Trine, suggested to me a place she knew that was still selling it.

I"m stunned, she was used to get it removed from the market. And now, she is telling me where to buy it.??????????? WT frick is going on, I am thinking.

As for OSR #2 the children are suffering from oxidative stress that is what the CDC's own research has found. Which causes inflammation of the brain, OSR #2 gets the children's own body to make the Glutathione needed to chelate the Mercury out of the child's brain.

The Inflammation is reduced in the brain, and the child starts coming back.

So the FDA is removing something that works, for our children. The IACC has spent
1 billion dollars, and come up with absolutely nothing to help our kids suffering.

The CDC has been in the chelation business for years, lead in inner city kids has been
chelated out with good success according to a person I talked to from the CDC.

I contacted the CDC, and asked the person there why is the CDC saying Chelation is Voodoo science? He said that's news to me, we have been doing it for yr's. He said,
and with good success.

The CDC does not want to admit this Autism epidemic is environmental. To do so, you would have to explain where children who have never been exposed to Mercury ended
up with Mercury in their bodies.

MSDS Manufacturer Safety Data Sheet = what the manufacturer says is the characteristics
of their product.

Considering the MSDS sheet of Thimerosal warns to not expose Pregnant women to
it for it can cross the placenta and go into the baby and cause mild to severe mental retardation. There is your first Mercury insult, the unborn fetus. Another early exposure, is the hep-b at birth. 12. 5 micro grams of Mercury that according to an NIH
paid study on baby primates. Has the ability, to cross the Blood Brain Barrier easier
than does the fish mercury. I will tell you why the CDC Dir. pushed pregnant women to
take not just one Mercury containing flu vaccine . But two.

Also on the MSDS was, If you are exposed to Thimerosal any future exposures to Mercury or Thimerosal may cause mercury poisoning. Not good considering the fact the children will be exposed to Mercury, via other Thimerosal containing Vaccines here is where it get totally insane. Some US. children are given as many as 9 vaccines at one point in time, with 7 containing the preservative Thimerosal and the only one given at 12.5 micro- grams is the
Birth dose by the hep-b vaccine. All others have full strength, 25 micro grams of a mercury in each vaccine. That again, has the insane ability to cross the BBB easier than does the fish Mercury.

The stupidity is not over yet, consider this is also on the MSDS "thimerosal is accumulative in the body, it targets the organs of the body in particular the brain and the lining around the brain"

Also this MSDS "never mix thimerosal with Aluminum" the toxicity will increase by 10 fold
Aluminum is in almost all children's vaccines as a catalyst. Definition of a Catalyst is an
immune system super charger.

Recently it was found out by six teams of Mitochondria specialist that children with a Mitochondria problem maybe turning Autistic by something pushing the Mitochondria
beyond it ability of it's metabolic reserves. The six teams suggested, that vaccines
have the ability to do that. These specialist, were from all over the world including the
US.

Back to incompetence and stupidity, from the MSDS " Thimerosal is a mutagenic "
Meaning, the Mercury based vaccine preservative used in almost all children's vaccines
and 80 % percent of all flu vaccines. Has the ability, to mutate genes.

They say they are finding Mutated genes in these kids, I say they are finding the Thimerosal handy work.

It appears those in vaccine safety, by allowing the pregnant women and children at birth to be exposed thimerosal, May have set up the perfect storm, needed for neurological damage
to occur in our children.

It appears those in vaccine safety does not heed warnings of any kind, even when they are from the manufacturer.

Never expose pregnant women to Thimerosal . They did

Never mix Thimerosal with Aluminum. They did that to.

Common sense tells you, if a manufacturer says it's product mutates genes and has
the ability to accumulate in the body and target the organs of the body in particular
the Brain and the lining around the Brain and 1 st exposure can cause one to be more susceptible to Mercury poisoning.

What do you want to bet, it's not a good idea to inject that into a child.

It doesn't take a rocket scientist to figure out, it's probably not a good idea to inject this into a child at birth.



lilady

@ ASD Researcher: How many more comments are in your huge tin of Spam?

You're not an ASD "Researcher" and you're not a lawyer.

IANAL...but my husband is...and you are clueless about the law in the U.K. and in the United States.

I bet John Walker-Smith would be a very cooperative "witness" if he is summoned to court//sarcasm.

ASD Researcher

The hidden hand of powerful forces
Doctor's Diary: Conspiracy theories and the GMC's recent ruling to strike professors Andrew Wakefield .and John Walker-Smith off the register.

http://www.telegraph.co.uk/health/healthadvice/jameslefanu/7804264/MMR-vaccine-the-hidden-hand-of-powerful-forces.html

It is not necessary to be a conspiracy theorist to recognise that the General Medical Council's recent ruling to strike professors Andrew Wakefield and John Walker-Smith off the register had the fingerprints of the medical establishment all over it. They had, it was alleged, brought the profession into disrepute by showing a callous disregard to the children in the (in)famous study investigating the possible role of the MMR vaccine in inducing a regressive variant of autism associated with severe bowel symptoms.

But this charge against them, as everyone knows, cannot possibly be true. Professor Walker-Smith, who supervised the investigation, is, from personal experience and by common consent, the epitome of the saintly doctor – "dedicated, honorable, held in the highest regard, a man of the highest calibre in his integrity, professionalism and clinical ability", as just one of the hundreds of affidavits from colleagues around the world puts it.

And so to the opinion of the parents of the vulnerable children whose best interests he had allegedly disregarded. "We were all treated with the utmost professionalism and respect… were kept fully informed about the investigations recommended… they were carried out without distress to our children, etc, etc."

It seems only sensible, given this moral confusion that would portray a decent and honest man as deceitful and exploitative, to reserve judgment about the GMC's verdict and to speculate what lies behind it. Leaving aside the question of whether the MMR vaccine is implicated in this form of autism – as the parents' accounts would certainly suggest – it is perhaps not unreasonable to detect the hidden hand of those powerful forces for whom the crushing of a professional reputation is a price worth paying for the continuation of the ever-expanding child immunisation programme.

------------------------------------------------------

Justice Mitting UK High Court - re Professor John Walker-Smith

Conclusion
For the reasons given above, both on general issues and the Lancet paper and in relation to individual children, the panel's overall conclusion that Professor Walker-Smith was guilty of serious professional misconduct was flawed, in two respects: inadequate and superficial reasoning and, in a number of instances, a wrong conclusion.

Miss Glynn submits that the materials which I have been invited to consider would support many of the panel's critical findings; and that I can safely infer that, without saying so, it preferred the evidence of the GMC's experts, principally Professor Booth, to that given by Professor Walker-Smith and Dr. Murch and by Dr. Miller and Dr. Thomas. Even if it were permissible to perform such an exercise, which I doubt, it would not permit me to rescue the panel's findings.

As I have explained, the medical records provide an equivocal answer to most of the questions which the panel had to decide. The panel had no alternative but to decide whether Professor Walker-Smith had told the truth to it and to his colleagues, contemporaneously.

The GMC's approach to the fundamental issues in the case led it to believe that that was not necessary – an error from which many of the subsequent weaknesses in the panel's determination flowed. It had to decide what Professor Walker-Smith thought he was doing: if he believed he was undertaking research in the guise of clinical investigation and treatment, he deserved the finding that he had been guilty of serious professional misconduct and the sanction of erasure; if not, he did not, unless, perhaps, his actions fell outside the spectrum of that which would have been considered reasonable medical practice by an academic clinician. Its failure to address and decide that question is an error which goes to the root of its determination.

The panel's determination cannot stand. I therefore quash it. Miss Glynn, on the basis of sensible instructions, does not invite me to remit it to a fresh Fitness to Practice panel for redetermination. The end result is that the finding of serious professional misconduct and the sanction of erasure are both quashed.

lookinglass

Some very timely reminders ASD of what the mainstream media in the UK is really thinking about the disgraceful GMC findings, but few of them had the guts to print. Thanks for that.
I understand that Wakefield's lawyers have recently made approaches to the GMC on his behalf re an Appeal. It canot happen soon enough I feel.

Science Mom

"I understand that Wakefield's lawyers have recently made approaches to the GMC on his behalf re an Appeal. It canot happen soon enough I feel."

That door has shut; the time for Wakefield to appeal is over. He should have done it when the opportunity for him to do so was there; he isn't a speshul snowflake that can re-write procedure.

lilady

"I understand that Wakefield's lawyers have recently made approaches to the GMC on his behalf re an Appeal. It canot happen soon enough I feel."

Your "understanding" is wrong lookinglass. That's the latest *scoop* that appeared on the AoA website. Just another lying bunch of comments and just another flag that they ran up the flagpole, to see if it would fly. Silly, gullible lookinglass that flag ain't gonna fly.

RRGaines

The only thing the absolution of Walker-Smith brought to light was the degree to which Wakefield had them all fooled. Care to explain why the other authors of the "study" retracted?

ASD Researcher

You first ... surprise me that you have a indepth knowledge of the issues surrounding the Lancet paper.

lookinglass

Remember ASD, Gaines is the comic turn in this melee. You may be pushing him a bit too far?

truthout

To save their careers, I can assure you as in the US you had better not ever say vaccines cause Autism or we will get you. Sickos, claiming to be good, doing evil
to save their pride in an already failing vaccine program. And of course their Golden
Retirement Parachute, would plummet to the ground if the vaccine makers had to
pay for the damage. They done. GSK and Merck stocks, would be down graded
to Junk status if it were to come out that the MMR was damaging kids.

Many have sold their souls to Pharma, concerning Vaccines and Autism.

lilady

truthout: You just lied...or you are delusional...when you stated this about journalist Trine Tsouderos:

Either she is being paid big bucks, or the paper she works for is. Not sure which,
but as God is my witness she told me where to get OSR #2 she said that they had
not stopped selling it yet.

If you can understand why someone would write a story about the EVILS of OSR #2
and then clue you in on where you can still get it. Is she is just doing her job, to
keep from losing her job...

That's all I know."

Did you actually pull the *Pharma Shill Gambit"?

Sickos, claiming to be good, doing evil
to save their pride in an already failing vaccine program. And of course their Golden
Retirement Parachute, would plummet to the ground if the vaccine makers had to
pay for the damage. They done. GSK and Merck stocks, would be down graded
to Junk status if it were to come out that the MMR was damaging kids.

Many have sold their souls to Pharma, concerning Vaccines and Autism.

You really need some serious help for your delusional or lying behaviors. Consider going to a psychiatrist for some medicine manufactured by "Big Pharma" and stop chelating/abusing your child.

Science Mom

Twyla and truthout, do you really believe you will prevail with copious numbers of and bloviated, absurd comments?

It really isn't bigger than Wakefield; this article is just about Wakefield and Mr. Deer or hadn't you noticed. Wakefield is an annoying, de-licensed fraudster who should have done the honourable thing years ago, admit his wrong-doing and move on. Instead he's found a living via American benefactors with more money than brains.

You feel as though your own self-styled plight is represented by him, lose him and you lose your unity and identity. It must sting to see him relegated to the depths of Alex Jones interviews, appearances in a park shelter (capacity 40) and running his scam out of a Pak n' Mail. But that is exactly where he belongs.

lookinglass

"Bloviated" that's a big word for you Autism Mum- (sorry Science Mum..- must be confusing you with someone else on the oxymoronic pit Respectful Insolence) - did someone just send that big new word to you, by email perhaps or is it from your well thumbed Thesaurus with the big writing.?
Twyla and truthout, these two pretendy science bloggers, the self styled Queens of ad homm and abuse, (which they really do believe is clever) are having their "jollies" - English slang expression, you can guess what it means - at the expense of both of you. Don't dignify them with replies. I like your posts and if you have any more please put them up, but don't come down to their level by replying to them. They are becoming more laughable by the hour and more offensive.

RRGaines

Cos you never use ad hominem, Lookinglass?

Oh, yes, you do. Naughty, naughty, naughty.

lookinglass

'Course I can and do sunshine! What are you then the comic turn? Don't answer that.

Science Mom

""Bloviated" that's a big word for you Autism Mum- (sorry Science Mum..- must be confusing you with someone else on the oxymoronic pit Respectful Insolence) - did someone just send that big new word to you, by email perhaps or is it from your well thumbed Thesaurus with the big writing.? "

Sounds like someone's backside is chapped. If that's a big word for you then it's no wonder you are having trouble keeping up and are reduced to flinging faeces. I know Autism Mum and she is fabulous but alas AoA "I-see-conspiracies-everywhere" sheeple, she and I are entirely different people. Keep up the whining about ad homs by using ad homs; it makes you look so special.

lilady

This article SHOULD have been about Brian Deer and the seminars at the University he will conduct this week, but Wakefield and his "agents" at Age of Autism, decided this would give him the opportunity to hold yet another "press conference" They have also decided to send sequential spammers to this blog.

They have no identity aside from their group wallowing in self-pity and what they perceive themselves to be, as parents of "vaccine-injured" children.

Wakefield is just another of their fallen heroes who has been reduced to a carney barker and his role as a snake oil salesman.

ASD Researcher

My child is not 'vaccine injured' he's a little guy with autism , quirky and loveable and some immune system problems. Severe asthma , food allergies and the bane of his life eczema.

That's why some of us in the autism community like to examine any aspects of a crosstalk between immune system and neurology.

Twyla

How do you know that myriad of immune system issues are not related to the effects of vaccines?

truthout

Don't you dare attack me, answer the truth I just shared about the MSDS sheet warnings.

Start there, and then explain how the CDC Dir. knew that according to the simpson wood transcripts. "you would never want to go any earlier with thimerosal or you would most certainly get more out comes"

From the MSDS

Pregnant women are never supposed to be exposed to thimerosal for it can cross the placenta and go into the baby and cause mild to severe mental retardation.

She the Dir. of the CDC knew all that, but as soon as she removed the Thimerosal from childrens vaccines. She was pushing pregnant women and children 6 mos to to years to take a flu shot, because she knew if you remove it children will not be sick anymore.

And it would become very evident, what had happened to a generation of very sick kids.

The Dir. of the CDC was telling pregnant women do not eat certain fish that may contain
Mercury. It may harm the unborn fetus. But do go down and get injected with 2 mercury containing flu shots, that contains a mercury that crosses the BBB easier than does the fish Mercury??????

Also she knew by the most current research from the UK institute of medicine, that children 6 mos to 2 yr's get absolutely no benefit from the inactivated flu vaccine.

Except that of a placebo effect.

So why would she tell pregnant women, and children 6 mos to 2 yr's to get a flu shot?

She and others, were afraid of the Autism rates would be dropping like a rock.

So armed with facts, she had. She the Dir. chose to poison more children?????

A legal term comes to mind, Premeditated poisoning.

The Dir. of the CDC took the revolving door into the industry, she was awarded for her
misleading the public. A job with Merck, for 2 million dollars a yr.

truthout

When breaking news at NBC ABC and CBS is Justin Beber throwing up on stage, and Lindsy Lohan is acting weird. In stead of the researcher that gave the CDC the proof that
they desired. That, mercury and the MMR was not harmful in children's vaccines.

You mean to tell me, that a man that gave the CDC proof the studies from Denmark proved mercury was safe to use in vaccines.

Has been indicted on 13 counts of wire fraud and 9 counts of money laundering.

And it does not even make, the nightly news.

You don't bite the hand that's feeding you, with million dollar drug commercials.

Seriously it's not breaking news, that the studies the IOM used to rule vaccines did not cause Autism. Were fraud, created out of thin air. They are finding out, that he did not even do some of the studies. He was paid to do.

It's not breaking news, that the researcher they hand picked to do the fraud they desired
bought himself 2 cars a Harley Davidson motorcycle and a house next to the CDC whom he committed fraud with. And wired himself almost 1 million dollars in cold blood stained cash.

It's not breaking news, the Denmark researcher said that when they removed the the
Thimerosal yr's before from the Denmark vaccines the rate kept on going up on Autism
so it couldn't possibly be the Thimerosal. That answer was yes, it was breaking news.

But it was not breaking news, when the Denmark researcher was proven not only a fraud but also a liar. By a FOIA email, sent to the CDC from a researcher from Denmark that said as of 2001 the rates of Autism continue to decline. Since they cannot be going up and down at the same time, who's right???? the fraud the CDC hand picked and told BTW " we are only interested in what will exonerate the CDC and the vaccines" that they handed a research contract to worth 11 million plus dollars. Or the person who has nothing to gain by telling the truth. I know which one, you will say was telling the truth.

I banking that the students and parents at LaCrosse never knew this truth, and can see the absolute corruption I just uncovered for them, so they can make an informed decision next time someone says. You need a flu vaccine.

truthout

Most if not all you people defending vaccines, are from a PR group hired to try to
discredit the parents of the vaccine injured. And you know it.

It's blood money , and one day you will answer to God for taking it on the backs of very sick children. That will be as bad as Hitlers, judgement was. Because they are 23 vaccines containing aborted fetal tissue. He will not be to happy, to see you defended
people that make organized crime look like the good guys. He does not like people who hurt or she blood of the innocent.

There is better ways to make a living, than attacking a parent already dealing with a
close to 7734 up side down as you can get situation.

Science Mom

"Most if not all you people defending vaccines, are from a PR group hired to try to discredit the parents of the vaccine injured. And you know it."

Really?! I'm getting paid to do this? Well I want my money then. Who do I demand from ? Which PR group? In the meantime, do you believe that because you are so passionately hawking OSR? An industrial waste chelator you are pushing down your child's gullet. Well done truthout, chelate vital minerals and nutrients from your child in the process of "curing" him. No need for anyone to be paid to discredit parents like you, you are doing a capitol job of that all by yourselves.

lilady

"Most if not all you people defending vaccines, are from a PR group hired to try to
discredit the parents of the vaccine injured. And you know it."

Sure thing truthout...like er, I would ever risk my professional license as a registered nurse. I'm doing G-d's work to advocated for developmentally disabled kids and adults and to expose child abusers/chelating parents like you.

mapleleafy

“Really?! I'm getting paid to do this? Well I want my money then. Who do I demand from ? Which PR group?”

Right. So what motivates a mom who doesn’t have a child with autism to spend so much time defending vaccines anytime the words autism-vaccine pop up on the net? Seriously? I’m sure that there are a lot of debates concerning health issues but why would anyone expend the energy and time (how many years now Science Mom?) in a debate or blog about that debate unless they had something to gain? The pro-vaccine stance IS the mainstream stance; no shortage of proponents (doctors, government reps, and paid shills) there. I have a reason to look for answers to what happened to my child and I wouldn’t be involved for any other reason. Who with a full life would volunteer for this? Is this the reason for the brand so that efforts through the quantity of posts get acknowledged?

Science Mom

I have children mapleleafy and that's all the motivation I need. You need to come to grips with the fact that there are many of us, mostly professional scientists and/or physicians who see this as part of their duty to correct misinformation. The fact that you need some nefarious motivation and accuse us of it with not a shred of evidence just shows how weak your arguments are and how insecure you are with your own abilities. If you can't stick to the issues then you have no business even discussing them.

mapleleafy

The fact is vaccination rates have never been higher in most first world countries.
Why the alarm?

Like you say, there's a lot of you. And people who want to claim authority as a "professional" should really use their real name. People with nothing to hide, hide nothing. Don't blame us; you branded yourself as 'science' mom. With all the "oohs and ahhs aren't you a clever bunny then" come all the suspicions of someone with industry ties and self-serving motives.

But of course now the average joe has access to pubmed and medical journals and news from other countries (as well as archived information) that they didn't have before when they had to take whatever they were being fed. "Experts say".... well now we want to know.... Who are these experts? And why do other experts say something else? And how much weight should we give these experts when they have ties to those companies/products they are promoting? Don't pretend it doesn't matter. And don't think that because someone didn't pursue a career in "science" that they can't read a study, ask questions and gather enough information to make a decision. And in the end: You (as in medical and science people) are NOT the boss of us! Sucks for those who thought years of jamming their nose in a book would place the coveted and beyond question authority card in their palm.

Science Mom

@ mapleleafy,

"The fact is vaccination rates have never been higher in most first world countries.
Why the alarm? "

They are not high enough and eroding in some areas to the point that once eliminated diseases are circulating again. Don't you follow any statistics? What are the current measles, mumps, rubella and pertussis rates in the UK? Japan? US? How about France's stunning measles epidemic? Do you think children are just recovering with no complications? No deaths? Think again and you want to bring that back. Brilliant.

"Like you say, there's a lot of you. And people who want to claim authority as a "professional" should really use their real name. People with nothing to hide, hide nothing."

Do I say I'm Dr. so and so and I say x, y and z? Nope. I learned quickly what people like you do to people like me in real life and no thanks, I feel dirty enough speaking to some of you. I don't need my family threatened or my employer harassed.

"Don't blame us; you branded yourself as 'science' mom. With all the "oohs and ahhs aren't you a clever bunny then" come all the suspicions of someone with industry ties and self-serving motives."

You don't get off the hook for accusing people of something with less-than-zero evidence because you're too insecure and paranoid to stick to the issues. It's a vile, dishonest tactic and just makes people like you look pathetic and desperate. Of all of us that your lot have "outed" and threatened, how many of them actually turned out to be shills? Not a single one no matter how hard you tried.

"But of course now the average joe has access to pubmed and medical journals and news from other countries (as well as archived information) that they didn't have before when they had to take whatever they were being fed."

So what? None of you can even understand the literature and hardly any of you have access to articles behind paywalls. Having access to limited information that you can't even parse does more harm than good.

"And don't think that because someone didn't pursue a career in "science" that they can't read a study, ask questions and gather enough information to make a decision."

But you don't do that though or you ask equally ignorant people questions. You come off as arrogantly ignorant; Dunning-Kruger in action or rather, "why the incompetent don't know they're incompetent." If you really believe that you can know as much as someone who went to medical school and has practised for several years or acquired terminal degrees and have conducted research that has to go through rigorous approval and publication then you are seriously deluded. You may not like that authority but it has been earned. What have you done that is anywhere on par with that?

"And in the end: You (as in medical and science people) are NOT the boss of us! Sucks for those who thought years of jamming their nose in a book would place the coveted and beyond question authority card in their palm."

Nope, you don't have to listen to us but where does that really leave you? When you have a really sick child or an emergency who do you have to rely upon? When you are sued and need to defend yourself who do you rely upon? Whenever you get into your car and drive who do you rely upon? Fix your plumbing? You need experts, I need experts. The difference between you and I is that I know my limitations and appreciate the fact that others can do what I can't. You just spit on anyone or any profession that you don't understand and decided you don't need.

Until you do.

mapleleafy

Science Mom,

If the diseases had really been eliminated, how could they possibly be circulating again? I'm old enough to have had most of those childhood diseases so you can't scare me. Are there sometimes complications? Of course! Is it tragic? Of course! But what no one ever asks is "What kind of care did they get, if any, and did this factor in the poor outcome"? Medical mistakes and pure arrogance coupled with incompetence kill a lot of people. But the only reason these children die is because some people don't vaccinate. Rubbish!

I have no problem sticking to the issues. You could have used any moniker but you chose what you did and now whinge because not everyone genuflects. No matter how hard you try to convince us otherwise, it just is not the norm to spend such an inordinate amount of time berating people with opposing views on one topic with no dog in the fight. And the rest of your post is like stepping in dog muck and I have no interest in spending my valuable time scraping the bottom of my shoes.

Science Mom

"If the diseases had really been eliminated, how could they possibly be circulating again? "

The fact that you could type this in earnest boggles the mind. Can you not think of the reason why? Really? Here are a couple of hints for you: vaccine rates and clustering. Please examine the statistics before saying something that is so monumentally obtuse.

"I'm old enough to have had most of those childhood diseases so you can't scare me."

I didn't know I was trying but thanks for letting me know what an easy mark you are.

"Are there sometimes complications? Of course! Is it tragic? Of course! But what no one ever asks is "What kind of care did they get, if any, and did this factor in the poor outcome"?"

Previously healthy children landed in the hospital in an ICU sometimes for over a month, some dead and some with permanent neurological disorders. Is this somehow poor care? I'm also referring to cases in developed countries. And people like you want this back and on a grand scale. What do you think will happen if vaccine rates continue to fall?

"Medical mistakes and pure arrogance coupled with incompetence kill a lot of people. But the only reason these children die is because some people don't vaccinate. Rubbish!"

Can you say red herring and denial? A baby too young to be vaccinated acquired measles from an intentionally unvaccinated seven year-old child in the paediatrician's waiting room. The infant spent the next month in an ICU on a ventilator due to pneumonia. Whose fault is this? Don't you ever look at outbreak tracing?

"I have no problem sticking to the issues. You could have used any moniker but you chose what you did and now whinge because not everyone genuflects. No matter how hard you try to convince us otherwise, it just is not the norm to spend such an inordinate amount of time berating people with opposing views on one topic with no dog in the fight. And the rest of your post is like stepping in dog muck and I have no interest in spending my valuable time scraping the bottom of my shoes."

Your obsession with my 'nym seems rather disturbing. Equally disturbing is your inability to see the irony of complaining about the time I spend contradicting misinformation while spending your time spreading information. Having a special needs child doesn't give you some kind of unique consideration for what is acceptable time spent arguing this issue. My dog is just different than your dog, that's all and it sounds as though you are upset at actually being challenged.

Twyla

Science Mom, Dr. Wakefield is not the basis of our unity or identity. He is just a brave, compassionate, highly intelligent, well educated doctor who researched his patients' health conditions and dared to not back down.

The injustice done to him is terrible. He should be working and winning accolades and helping to make progress in treating serious GI issues.

lilady

At what age was your son diagnosed with Autism Twyla?

Didn't your child have a preexisting genetic disorder which was diagnosed how many years before he was diagnosed with autism?

lilady

(This is like hitting the proverbial two birds with one stone)

@ Twyla and truthout:

You are both spamming here and using Robert F. Kennedy's article that was published (and since removed), from Rolling Stone and Salon websites for your beyond ludicrous conspiracy claims about the IOM and "mercury poisoning from vaccines"

Seth Mnookin, the author of The Panic Virus, has blogged about RFK Jr's article. I prefer this rather inclusive superb blog about the truthfulness of RFK's article, the many "revisions", "corrections" and the ultimate removal of the article from both the Rolling Stone and the Salon websites. Your use of his inaccurate, biased article as your "source"...does not look well for you both:

http://skeptico.blogs.com/skeptico/2005/06/robert_f_kenned.html

Try again..to impress us, with your "sources".

Twyla

Per Rolling Stone:
"Editor’s Note: The link to this much-debated story by Robert F. Kennedy Jr. was inadvertently broken during our redesign in the spring of 2010. (We did not remove the story from the site, as some have incorrectly alleged, nor ever contemplated doing so.) The link to the original story is now restored, including the corrections we posted at the time and the subsequent editorial we published about the ensuing controversy.

"To read the story, which appeared in the July 14, 2005 issue of Rolling Stone, please login or create a subscription to RS Plus."

http://www.rollingstone.com/politics/news/deadly-immunity-20110209

I actually didn't quote from the "Deadly Immunity" article but from an article about RFK jr. in Spectrum Magazine. But, I do not consider the article "Deadly Immunity" to be inaccurate, nor biased.

truthout

Not claims, we have the minutes of the IOM meeting and they reveal the CDC ordering the IOM to pay very little attention to the biological evidence. And to put all their confidence in the large population based VSD studies and in the two Denmark studies.

NIEHS Congressional report,found all the large population studies to be en-effect useless and the Denmark studies. were in her words [ worse ] than useless.

We now know why, Indicted on 13 counts of wire fraud and 9 counts of money laundering.

The person representing the CDC's Vaccine program at the IOM meeting was Dr. Mc McCormick. She told the committee, that Walter Orinstein the Dir of the vaccine program wants you to declare well these things are pretty safe on a population basis. She then tells them, what Walt wants,Walt generally gets.

How can you take anything away from all that, except the IOM was ordered to not find causation.

In fact Byron child magazine asked to see the contract between the CDC and the IOM
they were told by Curtis Allen spokesperson for the CDC that the contract was available but only in heavily redacted and blacked out format.

That's not scientific studies I hear ,it's desperate people that have accidentally done a very bad thing. That is now having to resort, to ordering people to do their will.

Twyla

Robert F. Kennedy Jr. in Spectrum magazine

"In 2006, Kennedy wrote an article for Rolling Stone magazine called 'Deadly Immunity.' The response to his piece was overwhelming: following the publication, Kennedy received thousands of letters and emails from all over the world. 'The astounding thing was how alike all of them were and that people from Mississippi to New Delhi shared such identical experiences. Here is the typical scenario I heard: A mother took her toddler to the doctor where he received a spate of vaccines, became ill that night, often with a fever, sometimes with seizures, then lost the language he had, developed stereotyped behavior and regressed into a looking-glass world of debilitated relationships and social isolation.'"

RFK jr. also says in this article that, "nothing prepared him for the resistance and anger he faced when discussing autism with politicians and the media. 'The unbelievable thing is how these children’s stories are suppressed by the medical community, big Pharma and the American press. There is a total refusal to have the discussion and derision towards anyone who tries.'”

http://rfkin2008.wordpress.com/2008/05/13/kennedys-autism-crusade-continues/

Vaccine induced autism is real, and often accompanied by inflammatory bowel disease. This is not a hoax, not fraud. Whether the benefits of our current vaccine program outweigh the risks can be debated, but to ignore the very real problems is a travesty.

And to ignore these problems shows a lack of confidence in medicine and science, as if it is completely impossible to do anything about these adverse reactions - no way to prevent them, no way to treat them - the only alternative is simply to deny them.

truthout

A side note, before I prove to you the IOM has indeed committed intellectual suicide.

A to aggressive vaccine program, meaning to many vaccines to early with to many
toxins and heavy metals. That have not been checked for safety, when used in combination.

Plus giving up to 9 vaccines at one point in time, Congressman Burton said in his testimony in his hearings on Vaccines and Autism. He said his grandson, had received 9 vaccines with 7 containing Mercury. His testimony went on to say, a few days later and his grandson was in full blown Autistic behavior.

( It's considered in scientific terms, as the synergy effect of the mixing a Toxin or heavy metal ) example; the two salts being mixed Mercury mixed with the catalyst Aluminum.


This is why our most precious resource ( our American children ) heath is failing.
When our kids are given vaccines, on the bloated vaccine schedule. They end up
playing,a very dangerous game of Russian Roulete

If a young American woman is going to have a boy, the chances for an Autistic child is escalated to a risk of 1 in every 32.

You are asking young women wanting to have a baby boy, to take a revolver with
32 chambers with 1 chamber loaded with a dependent child for life. Spin it and
take the chance, Bang!!!!! a dependent child for life. Or maybe, she is lucky this
time. What about next time? It's 1 in 32 boys now, is it going to be 1 out of every
two ????? in one to five yrs.

In china, it's considered a blessing to have a boy. And a curse, to have a girl.

Boys can work the field, and to help make the family's living the Chinese feel.

It will soon, not be a happy occasion here in the US. to hear "it's a boy

They scratch their heads at the CDC FDA & AAP wondering why the parents are opting out of vaccines or choosing a slower less aggressive schedule.

Her's a hint, Duh! they don't trust you any more, you lie and manipulate data to get any
results you want.


From a meeting where the AAP CDC and the FDA and all the vaccines makers
went when they had a light bulb moment.

" that they had just poisoned, the very children they are trusted to protect"

Because of a study done that revealed very bad news. If a child received 62.5 micro grams
of Thimerosal by age 3 mos. that child has a 2.48 times risk of receiving ADD ADHD Speech Delay or Autism.

Many of you collage students with ADD ADHD, would not have had to struggle so
hard to learn if the Mercury preservative was removed from the vaccines in 1982 like
the interim plan said to do.

Instead it was removed from Dog vaccines in 1990 because it was causing neurological damage dogs. It was left in children's vaccines, till 2002 with an expiration date of 2004.

They the FDA and the CDC and AAP were warned in a 1948 AMA funded study on the Toxicity of Thimerosal lead researcher was Dr. Frank Engley a university professor and
a brilliant microbiologist. Dr Engleys blue ribbon team found Thimerosal was toxic down
to an unbelievable level down to one one millionth of a gram. He said and that's about as toxic as you can get. Dr. Engleys team tried again, in 1982 to get the FDA to remove it.

Dr Engley just before he died said" if they had listened and followed through on our 82
report,then all the vaccines would have been freed from Thimerosal and they tell me all
this Autism may never have occurred.

I was watching a CSPAN hearing from the Government Reform committee on Vaccine safety and Autism. Congressman Dan Burton was the head of the committee, he was hearing testimony from a Dr. Egan from the Centers for Biologic s ( CEBER ) The Congressman asked Dr. Egan about the interim plant to remove the Thimerosal from 1982. He said you
had an interim plan to remove it in 82 why didn't you? Dr. Egans reply was very cocky. I was not with the agency back then, you will have to ask somebody who was.

The Congressman then said Ok! Dr Egan why has there not been any studies done by the FDA or the Manufacturer since 1929 and the only research done then was done on 22 people dieing of meningitis? They all died Dr. Egan and we don't if this stuff is safe or not!
Dr. Egan on your watch, we lost a generation of children.

That was it for the good Dr. Egan, he turned in to a potted plant at that point. His eyes were as big as saucers, he looked like a Deer caught in headlights. He couldn't speak anymore,
so the Congressman just shook his head and had this look of disgust on his face.

It took two women from the HHS, to hold him up and carry him out a side door.

A very savvy reporter from WFAA caught the Dr. being carried out by the two women from HHS her name was Valerie Williams. She stuck the mic in the face, of Dr. Egan and said
why is it Dr. Egan there has not been any research done,since 1929. One of the Women
from HHS said "if you want to know anything else you will have to call our press office"

Then they shuffled him out a side door.

( The FDA website, proudly announces they were followed for 1 single day )

From the Simpson wood transcripts, Dr. Weil the only person with a conscience
and a moral compass and apparently the only one in attendance that day with
any sanity.

Dr. Weil " you can play with the numbers all you want, they are linear and
statistically significant for the out comes. much like we found in other places
where people were Mercury poisoned.

That was his reply, to them saying.

"we can move the numbers around anyway we want, look justified in doing so. and get any results we want" That's what DR & Congressman Weldon, called selective use of the data.

It's also known as committing FRAUD to cover up your mistake. To protect, your Golden retirement parachutes..

The person there that day, that appeared to have the top position was Dr. Brent:
Page 229: of the Simpson wood transcripts;

"The medical legal findings in this study, causal or not, are horrendous
and therefore, it is important that the suggested epidemiological, pharmacokinetic,
and animal studies be performed. If an allegation was made that a child's neurobehavioral findings were caused by Thimerosal containing vaccines, you could readily find a junk scientist who would support the claim with "a reasonable degree of certainty". But you will not find a scientist with any integrity who would say the reverse with the data that is available. And that is true. So we are in a bad position from the standpoint of defending any lawsuits if they were initiated and I am concerned."

In a nut shell, that says the research points directly to Vaccines as a cause for
Autism. And they were concerned.

And he was concerned, but not about the children getting to much Mercury

Only about the fact, that they would all be in a bad position from the stand point of defending lawsuit's. Meaning that they would not fare well in a real court, with the evidence they had.

That's why they got busy, and started manufacturing supportive studies proving the safety
of vaccines out of thin air. And that's easily proven.

They agreed that day, to lie at Simpson wood as did the IOM in the 2004 report.
They agreed, the vaccine program is to big to fail. And if they were sued, they
could all lose their Golden retirement parachutes. And some were afraid they
could be sent to prison, not for the initial mistake. But the cover up that went
all the way up to the white house.

This Nation, that has been called the greatest Nation in the world. Is guilty!
of throwing their own vaccine damaged children under the bus. head first. In
an attempt, to save their Golden Retirements Parachutes. Sponsored by
Pharma, with Bribes and payoffs to silence those who would speak up about
the most costly medical mistake. [ in the history of mankind.]

That if left the way it is now, it will break this once Great Nations economy.

RRGaines

I'm sorry. If you can't differentiate between "to" and "too" from the get-go, I'm not going "to" read the rest of your rant.

Twyla

Parents read from the book "Silenced Witnesses"
http://www.cryshame.com/index.php?option=com_content&task=view&id=123&Itemid=228

Twyla

Michelle Gutierrez tells her daughter's story at a recent rally:
http://vimeo.com/50457858#

Twyla

This is all so much bigger than Wakefield. It is ridiculous how people continually assert that Dr. Wakefield caused all concerns about vaccines, about the MMR, about a link between the MMR and autism. I'm going to post a few stories of vaccine-induced autism. These are just anecdotes, and we are constantly told that "the plural of anecdotes is not data". But these stories would become data if properly studied, instead of summarily dismissed as coincidence. These stories illustrate the nature of the problem which needs to be addressed. Dr. Wakefield's work should have been the starting point for more research, instead of a cause for punishment. If people disagreed they should have done research to prove a different point of view, not taken away medical licenses.

*****
"Of course, after every round of vaccinations, he developed a very high fever and hysterical crying for three days, but that was all 'normal.' When he said his first word at 10 months old, my husband was thrilled that it was 'dada.' By 11 months old he was babbling away with 'mama' and 'dada' and a few other words... We had a happy, developmentally on-track baby, responding to his name, and terrific eye contact. At 12 months, our tour of duty began.

"At his 12 month old well-baby visit, my son received a round of vaccines that he never recovered from. By 13 months, he lost all speech, had low muscle tone, and minimal eye contact. He was zoned out most of the time and stopped responding to his name.

"The vaccines he received still contained thimerosal in 2003, two years after it was supposedly taken out, coupled with the MMR and Varicella shots, all at the same visit."

http://thinkingmomsrevolution.com/milestones/

This story (like many others) raises two very important issues in particular:
1) What vaccines can be given at the same time safely? MMR plus varicela plus additional vaccines containing thimerosal - why is that supposedly o.k.?
2) How can susceptibility to vaccine injuries be recognized? If he "developed a very high fever and hysterical crying for three days" after every round of vaccine, should that have been a red flag, to proceed with caution? Instead the reckless "stay the course, follow the schedule" mentality resulted in serious disability.
These are questions which must be understood better, but if we simply dismiss these events as coincidence or assume they are one-in-a-million, we will never learn more.

Twyla

Then the above mother writes, "At five years old, my son was diagnosed with hypothyroidism and type 1 diabetes. At six years old, he was diagnosed with a seizure disorder."
Hypothyroidism and type 1 diabetes are both autoimmune disorders. Do we really know what we are doing giving so many vaccines?

Ron Paul on vaccines. I'm not voting for Ron Paul, but he makes a lot of sense here. And, he is a doctor.
http://www.youtube.com/watch?v=f74xvtRijMc

RRGaines

They're both autoimmune? You're not big into medicine are you?

There are other causes of these conditions beyond the autoimmune. But I guess you mention autoimmune because it would fit your bias against vaccines.

ASD Researcher

CAT ... got your tongue ?

Twyla

"In the United States, the most common cause of hypothyroidism is Hashimoto's thyroiditis, a condition that causes the body's natural defenses-the immune system-to produce antibodies that over time destroy thyroid tissue. As a result, the thyroid gland cannot make enough thyroid hormone.

"Worldwide, iodine deficiency is the number one cause of hypothyroidism. Iodine added to salt, food, and water has eliminated this problem in the United States and other Western countries."
http://www.webmd.com/a-to-z-guides/hypothyroidism-cause

"Type 1 diabetes develops because the body's immune system destroys the beta cells which are in the islet tissue in the pancreas. These beta cells produce insulin. So people with type 1 diabetes cannot make their own insulin."
http://diabetes.webmd.com/guide/type-1-diabetes-cause

For both of these, autoimmunity is the most common cause. But what causes the autoimmunity? There may be various factors, including vaccines.

Studies have identified autoimmune reactions as part of autism as well, such as autoimmunity to the myelin basic protein which coats nerve cells.

lilady

Welcome Truthout...We so enjoy seeing another anti-vaccine spammer posting here.

I can't believe you are touting and quoting Boyd Haley. Here's an article about Boyd Haley written by Trine Tsouderos, a real science journalist, that appeared in the Chicago Tribune:

http://articles.chicagotribune.com/2010-01-17/news/chi-autism-chemicaljan17_1_dismay-upon-hearing-children-dr-l-jackson-roberts-expert-in-environmental-health

Read it thoroughly about Haley's marketing of an industrial chemical as a chelating agent. Look for one of the "journalists" who blogs at Age of Autism and how she sprinkled this industrial chemical on her childrens' breakfast cereal. I suppose that is less abusive than what another of the "journalists" at Age of Autism did to his child. He took his daughter to an offshore clinic to have her undergo intrathecal stem cell treatments and he blogged about it, as well.

No type of "treatment" is too outrageous, too invasive, too dangerous and too abusive for the anti-vaccine crowd and anti-vaccine bloggers to subject their children to.

lookinglass

Lilady
"No type of " treatment" is too outrageous, too invasive, too dangerous and too abusive for the anti vaccine crowd and bloggers to subject their children to"....How dare you be so offensive as to hurl such abuse at any parent who is despairing of their vaccine injured child .and is attempting to do his or her best to alleviate their pain. You have abslutely no God given right set yourself as their judge and moral dictator. I have already advised you need therapy. You are a disgrace and you have been reported several times already..

lilady

@ lookinglass: Then you are "comfortable" with the "treatment/cures/recovery" methods used by these parents...as I outlined above?

You have no moral compass and no compassion for these defenseless developmentally disabled children, who are being abused by their parents.

lookinglass

Lilady "moral compass" "compassion" ? You don't know the meaning of the words.I have repeatedly advised that youu are in need of therapy. I won't dignify your further comments with a reply.

AutismNewsBeat

Lookinglass, what are your thoughts on bleach enemas?

lilady

Let's see if lookinglass will stick the flounce.

truthout

The Professor and Chair of the Department of Chemistry, University of Kentucky's
Mercury program expert specialist Dr. Boyd Haley. Said ;

"the IOM committed intellectual suicide on this issue, and it is easily proven"

He is absolutely right, it is easily proven. The not so prestigious IOM agreed to
lie. The reason, their words were;

"if we release a negative report, the more negative the report the less likely people
are to use immunization / vaccination "

In other words, they are saying the American people cannot handle the truth.
The inconvenient truth,that they were willing to take to their grave. Was that the
fact that the vaccines have caused, in a subset group of children. The absolute
worse, and most expensive epidemic in American & maybe even. World history.

The CDC knew, or strongly suspected it to be a fact that the vaccines were not safe
for a subset group of children. In fact, the CDC has always said we cannot rule out
that this ( vaccines causing Autism ) maybe happening to subset group.

They cannot rule it out, because the biological evidence points directly to the Vaccines as a cause for Autism ADD ADHD and More.

That's why the CDC asked the IOM in 2004 to reevaluate their previous findings from 2001 - 02 findings, that said that it was biologically plausible. That vaccines, were causing the damage we are seeing in our most precious resource.

That's also why in 2004, the CDC ordered the IOM to pay very little attention to the biological evidence. And to put all their, confidence in the large population based studies.

The very studies, that the Vaccine compensation fund Special Master Hastings had
used to deny children with Vaccine induced Autism. The very compensation that
Congress, who passed the law had intended for them to get.

Turning the children down, for the compensation they were entitled to turned out to be
a massive mistake for the individual already broke and struggling states.

Because that meant, they were going to have to create the entitlement programs
needed like Governor Romney talks about. In order to pay for the lifelong care cost
of these vaccine injured children. State by State.

Here is a hint, that the Vaccine compensation program that Congress created
to protect the Vaccine makers from lawsuit's . Is for most, a con artist shell
game with no! pea to be found.

The Freedom of Information Act, is a very powerful tool. That sometimes exposes
a lot of corruption. It shines light on bad people, working for agencies doing wrong.
That are supposed, to be serving the people. Not selling them out.

Under the FOIA act, we know what people are saying. Even, behind closed doors.

A FOIA act email, sent from the CDC to the Government accountability office was obtained. In it, it's clearly evident that the Vaccine Compensation program was in the email expressing their concern. That, they cannot possibly pay for all the damage that the vaccine program has generated. They ended the letter, with "we only have 2 billion dollars"

The email or letter went like this" we have won three test cases, but there is 5000
more pending. and we only have, 2 billion dollars.

The letter or email was an attempt to keep the GAO's office from investigating them.
At the request of many, including Congress and Senate and parents of Autistic children.

For they knew, the CDC Dir. just admitted that all the large population studies done environmental were en effect useless. In particular the two Denmark studies, they
were found to be worse than useless.

The head of the NIEHS made a statement to a reporter, that sets it in stone that vaccines can cause Autism.

When she found all the large population based studies, were in her words. "en effect useless" She told a reporter

"that leaves the CDC with very little to say, that vaccines and Autism are not connected in anyway"

You will learn later, in my post. the large population studies were almost all created
out of thin air. By hand picked researchers, told to come to only one predetermined conclusion.

That the vaccine program, is safe. And does not! cause Autism.

And here's the proof, they knew or strongly suspected a link. The person representing
the CDC's Vaccine program at the IOM meeting was Dr. Mc McCormick. She told
the committee, that Walter Orinstein the Dir of the vaccine program wants you to declare well these things are pretty safe on a population basis. She then tells them, what Walt wants,Walt generally gets.

That statement safe on a population basis, appears to be a slippery slope that
could possibly lead to the extinction of all US. children. It appears, the more
vaccines added to the schedule and the earlier we go with the Toxins and heavy
metals. The number effected, (subset group) grows and has grown from 1 in
10,000 in 1979 to 1 in every 47 children in 2012 now has some form of Autism.

If you count ADD ADHD Bipolar & the massive jump in Asthma and childhood diabetes, that number is astoundingly much much higher. And is almost the sole reason, that health care cost in the US is higher than any other country. With no end in sight !!!!

truthout

Wait till the wave hits, it will be a tsunami taking with it. The US Economy,
all because of people in the health agencies and the medical community.
Who have misplaced pride, in an already failed vaccine program.

I will tell you, just how bad it will get. And I will use the Dir.of the IACC 's own
words against him. The IACC was created by Congress, to get to the bottom
of what is taking our children at astounding numbers.They have had 10 years,
spent 1 billion dollars. All to no avail. The Dir. of the IACC has always maintained,
we do not know if the increase is real increase. or not.

I guess he finally faced reality,because this is his most recent words pertaining
to the Autism epidemic.

"this is a real increase, how we prepare a Nation for 1 million who may need significant amounts of services"


"80 percent are under the age of 18 and they are working their way through the system
like a wave"

Well Dr. Insel, the wave people like you have created. Is now coming to shore and make
no mistake it will break, and divide this Nation.

The parents warned you AAP CDC FDA ,and when you were in the valley of decision to
tell the truth you chose to let pride speak for you. In other words you chose to lie to the public to save the very program that has made the American children sicker now than any
other time. In US. history.

I will Quote a brilliant Dr. a University of Kentucky Mercury Toxin specialist.
Dr. Boyd Haley.

I don't why the IOM (Institute of Medicine) committed intellectual suicide
but they did. And, it is easily proven.

The IOM in 2001 2002 come to the conclusion that it was biologically plausible
that the vaccines were in-deed causing Neurological Damage in children such
as ADD ADHD and Autism.

Weeks before the IOM was to reevaluate their previous findings the CDC is in an
email received through the FOIA act. This is the email

"we have searched frantically and cannot find anything here. "we are going to have to go else where and get us a study" They chose Denmark, and a researcher named Poul Thorsen the
CDC told him "we are only interested in what will exonerate the CDC and Vaccines"
they then awarded him a contract worth 11 million plus Autism research dollars.

He recently was indicted in Atlanta GA, on 13 counts of wire fraud and 9 counts of money laundering.

The indictment states,that he worked with others known and unknown by this grand jury.

Here's where you learn who his co conspirators were, Poul bought him a house next to the CDC in the USA. 2 cars a Harley Davidson motorcycle and wired himself almost a million dollars. The indictment states. Do you buy a house next to someone you stole almost 2 million dollars from? You do, if you had already committed the the fraud the CDC desired.
And you are now told we want you to be the head of the new DSM 5 he gave them what they
asked. "we are only interested in what will exonerate the CDC and Vaccines"

Congress should be questioning, why is it the CDC is not interested in finding out the truth?

"it's weeks before the IOM meeting, we have searched frantically and cannot find anything here. "we are going to have to go else where and get us a study"

That's what they believed behind closed doors, in the public they said

" we have good well designed robust studies, proving vaccine safety and proof that vaccines don't cause Autism"

Neither of which are true, the fact is the emperor has no clothes and never did. On this so very important issue.

Continued,

ASD Researcher

In response to ndavis

"That's really wacky."

Not really ... your question surrounded whether a doctor is able to interpret through years of professional experience the pertinent features of a patients history. That the Lancet paper clearly stated -

1. "We took histories, including details of immunisations and exposure to infectious diseases, and assessed the children. In 11 cases the history was obtained by the senior clinician (JW-S)."

2. "Onset of behavioural symptoms was associated, by the parents, with measles, mumps, and rubella vaccination in eight of the 12 children, with measles infection in one child, and otitis media in another."

I can't see where it says Professor Walker-Smith does not understand professionally "recall bias" or weighed that in his professional opinion.

"I do not doubt that Dr. Walker-Smith..."

It's Professor Walker-Smith.

"did the best that he could to record the intentionally-skewed information that was related to him by parents who had previously been contacted by Wakefield, anti-vaccine activists, etc."

So your argument is that the parents made up the clinical histories of their children ?

"But you know that."

No, I don't. Undermining your argument is that the children were referred to a paediatric gastroenterologist that undertook "clinical" care of the children and who saw many of the children over many years.

Also undermining your argument is this video and letter thanking the doctors particularly Professor John Walker-Smith for his care.

...and finally as to your last request ...

No ... thanks. My family and I enjoy our privacy.

ASD Researcher

Apologies here is the video ...

http://www.youtube.com/watch?v=DHrgYxqcU0w

ASD Researcher

In Reply to science mom

"Wakefield reported clinical, medical and parental histories that were disparate."

John Walker-Smith was the lead clinician, took the clinical histories except for one I believe and was praised by Justice Mitting for his clear accurate records.

"Wakefield was the senior author, Walker-Smith had an obligation to ensure that his role was accurately reported. "

All the roles are clearly set out in the Lancet paper - A J Wakefield was the senior scientific investigator. S H Murch and M A Thomson did the colonoscopies. A Anthony, A P Dhillon, and S E Davies carried out the histopathology. J Linnell did the B12 studies. D M Casson and M Malik did the clinical assessment. M Berelowitz did the psychiatric assessment. P Harvey did the neurological assessment. A Valentine did the radiological assessment. JW-S was the senior clinical investigator."

"He had nothing nice to say about Wakefield or his claims at his appeal and stated outright that doesn't support Wakefield's MMR-autism claim."

You don't seem to understand that there is more in the Lancet paper than just Andy Wakefield's hypothesis.

"Of course you wouldn't find fault if you are a fawning acolyte; I suppose you think David Lewis did Wakefield a favour too."

Personal abuse does not undermine the obvious value of the Lancet paper.

"Why would the Lancet paper have been retracted if not for serious fraudulent data collections that came to light during the GMC proceeding?"

What fraudulent data ? - that was not a finding by Justice Mitting of the UK High Court

"There were more than errors, there was outright fraud. "

Where if you think there is fraud you should state explicitly where it was and what evidence you have to back up your claim.

"And considering you are not a peer-reviewer, I daresay you aren't in much of a position to refute the reasons for the Lancet retraction."

The Lancet paper was not rejected by the peer reviewers or by the editor who wrote a commentary accompanying it.

"There was no unique gut pathology"

All you have to do is read Justice Mitting findings of fact - http://www.bailii.org/ew/cases/EWHC/Admin/2012/503.html

"only that found normally with chronic diarrhoea and constipation"

I'll take the expert opinion of the professor in paediatric gastroenterology.

"not "autistic enterocolitis"

Seems quite obvious to me autisitic - enetrocolitis = inflammation of colon , small intestine.
How do you explain that Harvard researchers found Autistic children had twice the risk of Inflammatory Bowel Disease and more than twice the risk of other bowel disorders.

How do you explain that the risk of IBD nearly triples as an autisitic child moves in to adulthood.

How do you explain the linkage to schizophrenia a condition in which 40% of sufferers have inflammation of the brain in the prefrontal cortex. Autistic children will develop schizophrenia at 6x the rate of other paediatric hospital patients.

"Wakefield trumped up the findings by an inexperienced pathologist and made up their own score sheet."

John Walker-Smith and his team of gastroenterologists / pathologists including Professor Dhillon a lecturer in pathology may those findings.

"What part of Dr. Walker-Smith's appeal not having anything to do with Wakefield's guilt are you having trouble with."

That is Professor Walker-Smith. The original allegations were founded on allegations against all three doctors. If the allegations are substantially quashed then it leads one to the very clear conclusion that nearly every other charge suffered from the poor application and reasoning that Justice Mitting found. It is also extremely problematic for those that raised the allegations because quite simply they were undeniably wrong.

It also is problematic for those who gave expert testimony against Professor Walker-Smith.

"Get over it "

Why ? A clear miscarriage of justice was done to one of the finest gastroenterologists that has lived. The evidence is clear that the Lancet paper is one of the pioneering works in Autism research. It also leads directly to the care and treatment of severely disabled children.

"Walker-Smith is separate from Wakefield in terms of the appeal and his role in the Lancet paper. "

The Walker-Smith work is the reason I post haven't you understood that ?

"The BMJ series reports Wakefield's fraud quite clearly and instead of suing Deer et al. in the UK, he cowardly tries to do it in the U.S. "

He lives in Texas.

"The failure to see that suit to fruition is part of the plan isn't it? "

Andy Wakefield has been slandered he has a right to access the courts to have his case heard.

"Tell me why Wakefield wouldn't have sued Deer et al. in the UK where jurisdiction is clear-cut?"

He lives in Texas , his family live in Texas , his two children lives in Texas and his dog is a proud Texan ... follows the Cowboys I believe.

"And none of it validates Wakefield's findings no matter how hard you try."

The findings were - (differing parts of the Lancet paper)

1. Onset of behavioural symptoms was associated, by the parents, with measles, mumps, and rubella vaccination in eight of the 12 children, with measles infection in one child, and otitis media in another. All 12 children had intestinal abnormalities, ranging from lymphoid nodular hyperplasia to aphthoid ulceration. Histology showed patchy chronic inflammation in the colon in 11 children and reactive ileal lymphoid hyperplasia in seven, but no granulomas. Behavioural disorders included autism (nine), disintegrative psychosis (one), and possible postviral or vaccinal encephalitis (two). There were no focal neurological abnormalities and MRI and EEG tests were normal. Abnormal laboratory results were significantly raised urinary methylmalonic acid compared with agematched controls (p=0·003), low haemoglobin in four children, and a low serum IgA in four children.
Interpretation

2. We identified associated gastrointestinal disease and developmental regression in a group of previously normal children, which was generally associated in time with possible environmental triggers.

3. Introduction
We saw several children who, after a period of apparent normality, lost acquired skills, including communication. They all had gastrointestinal symptoms, including abdominal pain, diarrhoea, and bloating and, in some cases, food intolerance. We describe the clinical findings, and gastrointestinal features of these children.

4. We describe a pattern of colitis and ileal-lymphoidnodular hyperplasia in children with developmental disorders. Intestinal and behavioural pathologies may have occurred together by chance, reflecting a selection bias in a self-referred group; however, the uniformity of the intestinal pathological changes and the fact that previous studies have found intestinal dysfunction in children with autistic-spectrum disorders, suggests that the connection is real and reflects a unique disease process."

" The mere mention of intestines and GI pathology isn't replication particularly when Wakefield has claimed relationship to MMR vaccines."

No it's not that can only be done by specifically investigating the physiology, neurology and genetics of those children this was a small case study.

Are you an "ASD researcher"? No. And neither is Wakefield."

In fact I am and have been for over 25 years. I'm also a parent of autistic child.

Merton

JRS, you are an "ASD researcher" in exactly the same sense that someone with more than one dictionary is a "lexicography researcher."

ASD Researcher

Are you referring to my personal family situation and my son's autism ?

I don't know if that is the best intellectual rebuttal of the issues I have raised.

ndavis

As an attorney (rather than an ASD researcher) surely you must have considered who might have discussed the cases with the parents before Walker-Smith had the opportunity to record the case histories reported by the parents.

Do you think that if Wakefield had contacted some of the parents directly and mentioned a possible connection of MMR to a child's problems; if attorneys had sent materials to or discussed with the parents the possible connection between MMR and a child's problems; or if parents had attended a talk given by Wakefield related to a connection between MMR and a child's problems or if parents already aligned with an advocacy group had discussed with a child's parents the possible connection of MMR with a child's problems, that Walker-Smith would have dutifully recorded the same history as if none of this occurred?

Really?

ASD Researcher

"that Walker-Smith would have dutifully recorded the same history as if none of this occurred?"

Are you suggesting that John Walker-Smith did not act in his full professional capacity as a clinician ?

That seems at odds to Justice Mitting and all the commentary from highly esteemed fellow professionals.

ndavis

That's really wacky.

I do not doubt that Dr. Walker-Smith did the best that he could to record the intentionally-skewed information that was related to him by parents who had previously been contacted by Wakefield, anti-vaccine activists, etc.

But you know that.

Please indicate the professional qualifications that suggest that you might appropriately call yourself "ASD Researcher" rather than, say, "Attorney with Access to the Internet."

Thanks,

Merton

What's your favorite thing about La Crosse, JRS?

Science Mom

Oh good grief; I certainly don't have the time to repeatedly respond to the same rubbish you post on any vaccine article or blog so I'll just hit some salient points.

In the interest of others who may be impressed with your verbiage, I should note that you are not any kind of researcher and it is woefully dishonest to present yourself as one. Having a child on the spectrum and spending way too much time obsessively abstract mining does not qualify one as a researcher.

Brian Deer did an excellent expose of Wakefield's fraud based upon what he gathered during the GMC FTP proceeding. I think we are all profoundly aware that you neither like nor agree with Mr. Deer's reporting and what a Wakefield fanboi you are but it looks as though Wakefield can't sue it away so you aren't left with anything substantive to support vapid claims that poor wittle Wakefield was libelled. No need to re-invent the wheel by repeating what Deer has articulately and accurately reported.

Wakefield is a citizen of the UK and claims he was libelled by a UK publication. He's no more American nor Texan (his poor choice of American Armoured Wankerball team aside) than David Cameron. So Wakefield can sing "Camptown Races", wear funny boots and hats and wrap himself in the American flag all he wants; if he was out to try and silence Deer and the BMJ then he should have done it in the UK and he knows it.

There is no such entity as 'autistic enterocolitis' and your tortured manoeuvring to make it so by claiming that gut pathology in autistic children is 'autistic enterocolitis' is laughable. And stop co-opting Mass General's, Harvard's and MIND's legitimate research; none of it replicates Wakefield's work; you're embarrassing yourself and Wakefield even more. Wakefield et al. didn't find anything unique, nothing that wasn't explained by chronic diarrhoea and constipation. I guess he shouldn't have "lost" those tissue samples huh blackheart? Repeating the same tired tropes don't make them any truer.

ASD Researcher

Guess what ... it's not all about the vaccines.


Try and think that one through ...


Science Mom

Gee you think blackheart? It also shouldn't be about Wakefield and his failed hypothesis but you like to keep beating that dead horse.

Let the real scientists do their jobs and follow the evidence. Stop posing as one and stop trying to validate a known liar and fraud. That is if you are really interested in the science. Oh interesting new study: http://leftbrainrightbrain.co.uk/2012/10/02/molecular-characterisation-of-gastrointestinal-microbiota-of-children-with-autism-with-and-without-gastrointestinal-dysfunction-and-their-neurotypical-siblings/

You should have a gander.

ASD Researcher

In reply to science mom...

"Gee you think blackheart?"

I must admit it is hard to gauge your depth in this debate.

"It also shouldn't be about Wakefield and his failed hypothesis but you like to keep beating that dead horse."

Then you haven't been comprehending my arguments and that's not my fault.

"Let the real scientists do their jobs and follow the evidence."

They are ... but seem to be constrained by a number of less than eloquent people that every time GI or the immune system is mentioned go to 'attack dog' phase.

"Stop posing as one and stop trying to validate a known liar and fraud."

There's a presumption of innocence , that's social justice ... worked for Professor John Walker-Smith.

"You should have a gander."

I already have ... David Austin one of the researchers published this in September 2011.

Ancestry of Pink Disease (Infantile Acrodynia) Identified as a Risk Factor for Autism Spectrum Disorders

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3173747/

Pink disease (infantile acrodynia) was especially prevalent in the first half of the 20th century. Primarily attributed to exposure to mercury (Hg) commonly found in teething powders, the condition was developed by approximately 1 in 500 exposed children. The differential risk factor was identified as an idiosyncratic sensitivity to Hg. Autism spectrum disorders (ASD) have also been postulated to be produced by Hg. Analogous to the pink disease experience, Hg exposure is widespread yet only a fraction of exposed children develop an ASD, suggesting sensitivity to Hg may also be present in children with an ASD. The objective of this study was to test the hypothesis that individuals with a known hypersensitivity to Hg (pink disease survivors) may be more likely to have descendants with an ASD. Five hundred and twenty-two participants who had previously been diagnosed with pink disease completed a survey on the health outcomes of their descendants. The prevalence rates of ASD and a variety of other clinical conditions diagnosed in childhood (attention deficit hyperactivity disorder, epilepsy, Fragile X syndrome, and Down syndrome) were compared to well-established general population prevalence rates. The results showed the prevalence rate of ASD among the grandchildren of pink disease survivors (1 in 25) to be significantly higher than the comparable general population prevalence rate (1 in 160). The results support the hypothesis that Hg sensitivity may be a heritable/genetic risk factor for ASD.

-------------------------------

Can you let Matt know ?

Yellowriver

It always amuses me when people call parents of vaccine injured children anti-vaxers. What a cop out on their behalf, I am not anti vaccine all I have ever wanted is safe vaccines. No vaccine is 100% safe and the VDPU in the UK was set up because of this very fact. I bet though if you look at their records they rarely pay out even though there are hundreds of thousands of adverse vaccine reactions. View my site www.followingvaccinations.com to read parents voices of vaccine injury and add your voice too. For people who slag off parents who know their child/children reacted badly to any vaccine please have the decency to have compassion for these parents and their families.

lilady

@ Yellowriver:

"It always amuses me when people call parents of vaccine injured children anti-vaxers. "What a cop out on their behalf, I am not anti vaccine all I have ever wanted is safe vaccines."

Which vaccine, do you consider safe?

Which vaccine has been "proven" to have more serious adverse reactions, than the disease that it protects against. (Please provide citations because your website is a collection of anecdotal stories).

No doctor, no nurse, no science blogger or research scientist has EVER stated that all vaccines, or any one vaccine is 100% safe...not on this blog or any other science blog. They know how to read the data, how to separate anecdotal information that is promulgated on the internet from actual serious adverse events...that rarely occur (on the order of 1:1,000,000 doses).

BTW, I read some of the content on your site and you sing the praises of Andrew Wakefield and the notorious anti-vaccine websites in the United States and in the U.K. (such as JABS). Are you affiliated with JABS?

Yellowriver

BTW, I read some of the content on your site and you sing the praises of Andrew Wakefield and the notorious anti-vaccine websites in the United States and in the U.K. (such as JABS). Are you affiliated with JABS?

You just can't stop yourself can you lilady, shame on you!! Are you affiliated with Becky Fisher aka Brian Deer

mapleleafy

Don't forget Brian Lawrence aka Brian "that's not bowel disease, that's diarrhea" Deer.

lilady

You work for the Autism Media Channel and the Autism Network..both of which are anti-vaccine media outlets.

You didn't answer my questions:

Which vaccine, do you consider safe?

Which vaccine has been "proven" to have more serious adverse reactions, than the disease that it protects against. (Please provide citations because your website is a collection of anecdotal stories).

lilady

BTW Yellowriver...Say hello to your co-worker at the Autism Media Channel:

http://www.linkedin.com/pub/carmel-wakefield/13/859/590

mapleleafy

".....They know how to read the data, how to separate anecdotal information that is promulgated on the internet from actual serious adverse events...

Indeed. I guess that is why the vaccine uptake for medical personnel is so dismal that they now have to threaten nurses with wearing masks or leaving their employment if they don't consent to the flu vaccine. And who could forget the H1N1 kinda sorta not at all pandemic and the lack of interest in the vaccine by the medical community:

65% of French nurses will refuse “swine flu” vaccine over safety concerns
http://www.syndicat-infirmier.com/Vaccin-H1N1-Resultats-de-la.html

......hospitals expect only a faction of staff to volunteer to receive the vaccine.
One urban hospital chief executive, speaking anonymously to the Guardian newspaper, said: “At the moment in my hospital, if nothing changes then it could be that 10%-20% of staff have the swine flu jab.”
http://tinyurl.com/yllmme3

One might think that the arrival in Germany of the first of 50 million doses of swine flu vaccine on Monday might be cause for celebration. But with news breaking over the weekend that top government officials in Berlin will be injected with an alternative vaccine -- one widely seen as safer -- a debate about an alleged two-class medical system has erupted. http://www.spiegel.de/international/germany/0,1518,656028,00.html

GPs get extra pay to vaccinate staff against swine flu Exclusive: A group of PCTs is to pay practices extra for immunising healthcare workers against swine flu as NHS managers admit many GPs are set to refuse to have the vaccine.
http://www.pulsetoday.co.uk/newsarticle-content/-/article_display_list/11015764/gps-get-extra-pay-to-vaccinate-staff-against-swine-flu

"We think there should be informed consent," [CMA president Dr. Robert] Ouellet said in an interview. "Everyone should have the right to refuse a vaccination if they think it's not right for them."
"It's a human-rights issue," said Linda Silas, president of the Canadian Federation of Nurses Unions. "It's like any medication or vaccination. You cannot impose it on workers, and you cannot impose it on a community." http://www2.canada.com/topics/bodyandhealth/story.html?id=1820019

Yellowriver

@ Lilady

A person goes to a doctor when one feels sick, the doctor asks "Whats the matter, how can I help" so one tells the doctor the symptoms they are feeling. The doctor checks and asks more questions so what the person tells the doctor is anecdotal and the doctor accepts it.
A person goes into a sandwich shop and the shop keeper asks them what they would like and the person says I'm hungry can I have a chicken sandwich and the shopkeeper gives over the sandwich no problem because he believes the customer is hungry. In these two cases the doctor or the shop keeper have not asked for scientific evidence of the person being ill or the person being hungry.

Science Mom

@ Yellowriver; most claims of vaccine injury aren't. You may not like it but it's true. Parents of truly vaccine-injured children get the utmost sympathy but unfortunately, there are many parents (mostly of the "vaccines cause autism" persuasion) who make that claim even when it is shown to them that their recollection is false and/or they are attributing injury to vaccination when there is another more plausible factor that they deny. I know because I have caught numerous parents revising their child's history to fit with vaccine timing. Jenny McCarthy is a good example of this; her son didn't have his first seizure for a year and a half after his MMR yet she attributes them to it. She attributes her ridiculous biomed abuse to "curing" his autism yet he is on anti-seizure medication and quite possibly has Landau-Kleffner syndrome and not autism which would seemingly resolve when seizures are controlled.

ASD Researcher

I'm sure Ms McCarthy's children are more than adequately looked after by paediatricians including their diagnosis.

For your information and why you should keep up with the latest research.

Epileptic encephalopathies of the Landau-Kleffner and continuous spike and waves during slow-wave sleep types: Genomic dissection makes the link with autism.

http://www.ncbi.nlm.nih.gov/pubmed/22738016

Purpose:  The continuous spike and waves during slow-wave sleep syndrome (CSWSS) and the Landau-Kleffner (LKS) syndrome are two rare epileptic encephalopathies sharing common clinical features including seizures and regression.

Both CSWSS and LKS can be associated with the electroencephalography pattern of electrical status epilepticus during slow-wave sleep and are part of a clinical continuum that at its benign end also includes rolandic epilepsy (RE) with centrotemporal spikes.

The CSWSS and LKS patients can also have behavioral manifestations that overlap the spectrum of autism disorders (ASD). An impairment of brain development and/or maturation with complex interplay between genetic predisposition and nongenetic factors has been suspected.

A role for autoimmunity has been proposed but the pathophysiology of CSWSS and of LKS remains uncharacterized.

Methods:  In recent years, the participation of rare genomic alterations in the susceptibility to epileptic and autistic disorders has been demonstrated. The involvement of copy number variations (CNVs) in 61 CSWSS and LKS patients was questioned using comparative genomic hybridization assays coupled with validation by quantitative polymerase chain reaction (PCR).

Key Findings:  Whereas the patients showed highly heterogeneous in genomic architecture, several potentially pathogenic alterations were detected. A large number of these corresponded to genomic regions or genes (ATP13A4, CDH9, CDH13, CNTNAP2, CTNNA3, DIAPH3, GRIN2A, MDGA2, SHANK3) that have been either associated with ASD for most of them, or involved in speech or language impairment, or in RE.

Particularly, CNVs encoding cell adhesion proteins (cadherins, protocadherins, contactins, catenins) were detected with high frequency (≈20% of the patients) and significant enrichment (cell adhesion: p = 0.027; cell adhesion molecule binding: p = 9.27 × 10(-7) ).

Significance:  Overall our data bring the first insights into the possible molecular pathophysiology of CSWSS and LKS.

The overrepresentation of cell adhesion genes and the strong overlap with the genetic, genomic and molecular ASD networks, provide an exciting and unifying view on the clinical links among CSWSS, LKS, and ASD

Science Mom

"I'm sure Ms McCarthy's children are more than adequately looked after by paediatricians including their diagnosis."

One child. Fortunately she hasn't sought to perpetuate her genes any further. And considering her "paediatricians" are Jerry Kartzinel and Jay Gordon, 'adequately' would be an overstatement.

"For your information and why you should keep up with the latest research."

Is there any possible point to this other than to perpetuate your ruse as an "ASD researcher"?

mapleleafy

"Fortunately she hasn't sought to perpetuate her genes any further."

Wow. How old are you, fourteen? I'm not a fan of JM but perhaps you would like to put your parenting skills on display for all to see and then we can judge whether you should be procreating. Long day doing "sciencey" things and now putting a fair bit of time online as a vaccine apologist. If there is any disbelief over 'nyms I'm thinking it's over the second word in yours (and btw, lovely appeal to authority with the first).

Science Mom

" I'm not a fan of JM but perhaps you would like to put your parenting skills on display for all to see and then we can judge whether you should be procreating."

Sure thing; for starters I took really awesome care of myself during pregnancies. I do believe Jenny blithely stated she ate nothing but junk, smoked and drank during hers. I don't abuse my children in any way shape or form; Jenny subjects her poor child to dangerous and unproven therapies and medicines that aren't even indicated. Oh and I'm fiercely protective of my children, have respect for them and their integrity and don't talk about them or their bodies/bodily functions in public. Too bad Jenny lacks that respect for her own child for the world knows the poor kid has a bit that looks like a "shrivelled french fry". What a great mum and autism advocate she is, you're welcome to her.

Twyla

Science Mom, you think you can differentiate between the "truly vaccine-injured children" and the not truly vaccine-injured based on a parent's comments? That's not scientific at all.

Yellowriver

Nice one Twyla

lilady

"Oh, look, it's pretend scientist John Richard Smith."

Thanks Merton. I stated that I read ASD Researcher's spam posted under a difference "nym, somewhere. It was on the Huffington Post.

You've been busted ASD Researcher.

ndavis

Perhaps those of us who actually have training in science and medicine should adopt 'nyms like "Legal Researcher" since we, too, can google.

Hint to ASD Researcher: I've spent most of my life around other scientists and physicians--and none of us would write something like "this is exactly what was found in further research undertaken by researched and medical officers at Harvard Medical and Boston Children's hospital."

Pathetic poseur.

lilady

@ ndavis: I just *knew* that I've seen ASD Researcher's spam before...but Merton nailed him.

I've been known to post on the Ho-Po under my same 'nym, and there are a small group of spammers, such as John Richard Smith, who post on each and every autism and vaccine thread. At the Ho-Po he's just ignored.

BTW, you did a spectacular job of analyzing his spam and the disgraced former doctor's fraudulent study.

ASD Researcher

Allow me to edit my work (there was a typo)

"this is exactly what was found in further research undertaken by researchers and medical officers at Harvard Medical and Boston Children's hospital."

ndavis

Yes, that's just what I mean: none of my colleagues would write like that.

My fellow students at Harvard and my spouse, who was a researcher at Boston's Children's Hospital before turning to medicine, would put it differently. Since I trained in medicine and biological research rather than in the law, I suppose that you might detect a similar disconnect if I tried to Google something in your area--which certainly appears to be closer to the law than to medicine.

ASD Researcher

II believe all of us are able to comment freely on this matter. Whatever occupation or role in life does not bar one from the freedom of making polite, reasonable argument.

ndavis

"I believe that all of us are able to comment freely on this matter.

OTOH, most people would probably not intentionally misrepresent their position by calling themselves something like "ASD Researcher" rather than something like "an attorney with an internet connection."

ASD Researcher

We do not fully understand what autism is , how it starts , how it develops and what are the variety of paths it takes ... many medical researchers and scientists are trying to untangle various complex relationships between a number of factors that centrally involve , neurology , physiology and genes.

The immune system is central to many of the new research findings made in just the last two years ... for instance in genetic work undertaken by Mark Ziats and Owen Rennert
National Institutes of Health researchers they underlined the importance of immune signalling pathways.

"Taken together, our findings integrate a large set of genes implicated in ASD and suggest that they may converge onto classical cytokine signaling pathways. While other transcriptomics studies on ASD tissue have implicated immune system signaling in ASD pathogenesis, our findings suggest that the ASD-implicated genes themselves may also be related to these functions.

Interestingly, there is also mounting evidence at the cellular and tissue levels that more in depth investigation of an immune component is warranted in ASD .

For instance, multiple studies have demonstrated altered cytokine profiles in ASD patients and altered TGF-B concentration in serum and CSF correlates with disease severity.

Others have described various autoimmune phenomena including autoantibodies to neural antigens and maternal-fetal cross-reactive neural antibodies.

There is also indication of altered innate cellular immunity in ASD, such as differences in gene expression and altered response to immunostimlulatory ligands in both natural killer and monocytic cells from ASD patients.

Post-mortem brain tissue from ASD patients shows increased microglial density in grey matter, an activated morphology, and secretion of a cytokine profile consistent with a pro-inflammatory state, most prominent in the cerebellum.

Moreover, microglia from MeCP2- null mice—a model of the Autism Spectrum Disorder Rett Syndrome—produce a conditioned media that damages synaptic connectivity via a glutamate-excitotoxicity mechanism.

While all of this work provides post-hoc evidence for altered immune response in ASD, our results suggest a direct link between implicated genes in ASD and molecular pathways involved in immune signaling."

One of , if not the world's leading Geneticists Dan Geschwind (UCLA) using Gold Standard gene network analysis found ...

" that the specially expressed genes in autism fell into two groups, one having to do with synapses and neuronal function, and the second having to do with glia and immune function. This place immune function once more at the heart of autism gene network activity."

Nothing speaks louder than science on this issue.

Science Mom

"Nothing speaks louder than science on this issue."

Correct and why Wakefield et al. don't have any credibility on the issue since they didn't adhere to rigorous methodology. Furthermore, their study subjects didn't have any abnormally unique GI pathology and medical records were disparate from parental reporting. Child 11 is a stunning example of this. It is dishonest or a flight of fancy to imply or state that Wakefield was "onto something" by writing about a few children with a falsified gut pathology.

Please allow the real researchers do their work and stop co-opting their good work to try and validate Wakefield's clearly fraudulent studies.

ASD Researcher

"Wakefield et al. don't have any credibility on the issue since they didn't adhere to rigorous methodology."

by et al I suppose you mean Professor John Walker Smith now substantively cleared of all charges on appeal to the UK High Court, who also took the majority of clinical histories, which produced the data ?

To which the judge commented in his findings "Professor Walker-Smith saw child 3 at an outpatient's clinic on 3rd April 1996. As usual, a careful clinical history was taken. " or " appointment was fixed for 2nd October 1996, during which Professor Walker-Smith took his usual detailed clinical history" or "Child 9 was seen by Professor Walker-Smith at his outpatients clinic on 8th November 1996. As usual, he recorded a detailed clinical history,"

http://www.bailii.org/ew/cases/EWHC/Admin/2012/503.html

"they didn't adhere to rigorous methodology."

I could find no fault with the way the Lancet paper was presented or the way in which the clinical history was gathered. In one case it was a junior doctor but the term junior does not mean error prone.

"Furthermore, their study subjects didn't have any abnormally unique GI pathology"

That was not the expert opinion of either Professor John Walker-Smith , his fellow gastro / pathology team or for that matter Justice Mitting in his findings.

"writing about a few children with a falsified gut pathology."

That was not the finding of the UK High Court after it examined Professor John Walker-Smith's testimony and accompaning evidence (all the evidence).

"and validate Wakefield's clearly fraudulent studies"

There is no evidence that has been tested by a court that the John Walker-Smith / Andrew Wakefield study was in anyway fraudulent. The UK High Court findings found that there was a clear clinical base to all the proceedings.

Further independent research has evidenced quite profoundly the matters pertaining to immune system , inflammation , regression and GI in cohorts of ASD children.

Professor John Walker-Smith was quite simply Europe's top paediatric gastroenterologists I take his medical and scientific evidence above all else , especially considering two quite important factors. He was the senior clinician with years of experience that saw each and every child and was familiar with every medical aspect and pathology of each child.

Are you a Professor in paediatric gastroenterology ? No.

Science Mom

"by et al I suppose you mean Professor John Walker Smith now substantively cleared of all charges on appeal to the UK High Court, who also took the majority of clinical histories, which produced the data ?"

Wakefield reported clinical, medical and parental histories that were disparate. Wakefield was the senior author, Walker-Smith had an obligation to ensure that his role was accurately reported. He had nothing nice to say about Wakefield or his claims at his appeal and stated outright that doesn't support Wakefield's MMR-autism claim.

"I could find no fault with the way the Lancet paper was presented or the way in which the clinical history was gathered. In one case it was a junior doctor but the term junior does not mean error prone."

Of course you wouldn't find fault if you are a fawning acolyte; I suppose you think David Lewis did Wakefield a favour too. Why would the Lancet paper have been retracted if not for serious fraudulent data collections that came to light during the GMC proceeding? There were more than errors, there was outright fraud. And considering you are not a peer-reviewer, I daresay you aren't in much of a position to refute the reasons for the Lancet retraction.

"That was not the expert opinion of either Professor John Walker-Smith , his fellow gastro / pathology team or for that matter Justice Mitting in his findings."

There was no unique gut pathology, only that found normally with chronic diarrhoea and constipation, not "autistic enterocolitis" which is not accepted by any GI specialist anywhere in the world. Wakefield trumped up the findings by an inexperienced pathologist and made up their own score sheet.

"That was not the finding of the UK High Court after it examined Professor John Walker-Smith's testimony and accompaning evidence (all the evidence)."

What part of Dr. Walker-Smith's appeal not having anything to do with Wakefield's guilt are you having trouble with. Dr. Walker-Smith's appeal was about his role and what he knew or didn't know. He was duped by Wakefield and why his appeal was successful.

"There is no evidence that has been tested by a court that the John Walker-Smith / Andrew Wakefield study was in anyway fraudulent. The UK High Court findings found that there was a clear clinical base to all the proceedings."

Get over it; Walker-Smith is separate from Wakefield in terms of the appeal and his role in the Lancet paper. The BMJ series reports Wakefield's fraud quite clearly and instead of suing Deer et al. in the UK, he cowardly tries to do it in the U.S. The failure to see that suit to fruition is part of the plan isn't it? Tell me why Wakefield wouldn't have sued Deer et al. in the UK where jurisdiction is clear-cut?

"Further independent research has evidenced quite profoundly the matters pertaining to immune system , inflammation , regression and GI in cohorts of ASD children."

And none of it validates Wakefield's findings no matter how hard you try. The mere mention of intestines and GI pathology isn't replication particularly when Wakefield has claimed relationship to MMR vaccines.

"Are you a Professor in paediatric gastroenterology ? No."

Are you an "ASD researcher"? No. And neither is Wakefield.

Twyla

Regarding Child # 11 -
Here is an interview with his father:
http://www.ageofautism.com/2011/11/an-elaborate-fraud-series-part-7-in-which-the-bmjs-prime-example-of-wakefields-alleged-misconduct-pr.html

Science Mom

"Here is an interview with his father:"

Twyla, there is a whole other world out there that isn't AoA and it's a darn sight more accurate. Didn't you make a comment about "thinking outside of the box"? Yet here you are with copypasta from your little box. Child eleven's father threw Wakefield under the bus too and wasn't pleased with the reporting of his child.

lilady

I've seen this same copy pasta before that ASD Researcher is presenting...only under a different 'nym.

Of course, the studies, that he has purportedly analyzed, do not confirm Wakefield's new *syndrome* "autistic enterocolitis". The fact remains that most of the co-authors on the study disavowed the study and the Lancet finally retracted the study that they published.

Wakefield's "new syndrome" could have been confirmed save for the fact that all the specimens "went missing" and all the histopathology reports "went missing" as well.

Clearly, the conclusions drawn by ASD Researcher that reference Wakefield's work and Walker-Smith's participation, indicate that ASD Researcher is not a gastroenterologist and has not read the transcripts from the Wakefield GMC Fitness to Practice Hearing.

Merton

Oh, look, it's pretend scientist John Richard Smith.

ASD Researcher

I'm always happy to explain the research findings, particularly relating to complex issues such as autism.

Rebecca Fisher

No, "BeckyFisher" - you're clearly a fan, I'm so pleased - you've got it all wrong. Wakefield did, and does champion the link he made up between MMR and Autism, that link has been thoroughly discredited, as has Wakefield, and the quote you mentioned didn't mention the Lancet.

He's now reduced to giving media appearances in a shed.

AutismNewsBeat

It's even worse than that; Wakefield has appeared at crank conventions with 911 Truthers.

Yellowriver

How can Becky Fisher aka Brian Deer aka Rebecca Fisher be a fan when he/she runs the most silliest site I've seen in my whole life called http://jabsloonies.blogspot.co.uk/

One must be losing it when one posts as one name and then attacks that post as another name, no one is fooled.

lilady

The Dachel-bot is alive and well and has graced us with her thread spamming comments.

Anne Dachel is the Media Editor of the Age of Autism. She always posts these same spam from her large repository of canned comments. She was blocked from posting her spam last week at the San Francisco Chronicle.

You're too late for the discussion Ms. Dachel...you sent your minions over from Age of Autism and they have failed miserably to defend the disgraced former doctor Andrew Wakefield.

lookinglass

I see that you and "your minions" Lilady are here as always, eager to reduce the level of this discussion - as per your Left BrainRightBrain Forum - how tempting to write NoBrain, but that would be taking a withered leaf out of your own book Lilady would it not - i.e. that one of continuous ad hominem. Lilady you have been reported ad nauseum here there and everywhere but the mods here are stll in a state of shock I imagine at the unexpected degree of division and abusive rhetoric that Brian Deer loves to inspire, wherever he treads.
The Gospel according to Brian Deer is on its own roadshow! Can't wait, I look forward to Saturday.

Science Mom

"I see that you and "your minions" Lilady are here as always, eager to reduce the level of this discussion - as per your Left BrainRightBrain Forum - how tempting to write NoBrain,"

Lilady does not own nor contribute to LB/RB. It is dishonest of you to try and attribute her comments here to LB/RB and denigrate the website with your infantile insults. If you can't address commentors and content directly then you have no business commenting at all.

lookinglass

Ah so it's yet another pit of misinformation is it, knew I had seen her name somewhere.. It really doesn't matter Science Mom. The LBRBNB site that you yourself contribute to so enthusiastically is also a dedicated follower of the Brian Deer Roadshow. It deals in ad hom just as enthusiasticallyl, thrives on abuse and msinformation and puts the defamation of Andrew Wakefield way above the sincere pursuit of science in order of importance. And that is a direct comment Mom.

Science Mom

@ lookinglass, perhaps you should acquire some understanding of a couple of things. First, I'm also not a contributor to LB/RB; I have never written a post for them. Secondly, unlike your echo chamber at AoA, you are free to post comments at LB/RB and lastly, considering what is currently being written about anyone who is opposing you on AoA, I hardly think you are in a position to whine about ad hominem, abuse and misinformation since that is the very mainstay of AoA. Why they even have a resident stalker who is proudly patted on the head by commentors and contributors there.

AutismNewsBeat

"Can't wait, I look forward to Saturday."

Why, what's happening on Saturday?

lookinglass

Look at the calender. Brian Deer's Roadshow packed up hopefully and is on a plane back to the UK. God help us. Nobody wants him here either.

lilady

lookinglass: I am a retired public health nurse and I have no affiliation with LB/RB nor any other blog.

I am also the parent of a child born with a rare genetic disorder. He had pronounced autistic-like behaviors and he died eight years ago, peacefully in his sleep. His survival for 28 years was beyond what was predicted for him because he was immune suppressed, had a bleeding disorder (pancytopenia) and his grand mal seizures led to episodes of Todd's paralysis.

I have been a child advocate for 36 years for services for children, adults and their families who have developmental disabilities. I despise the medical abuse of Wakefield's study subject and the abuse of children with some of those awful "biomedical treatments" such as castration, chelation, bleach enemas and other painful useless attempts to "treat/cure/recover" autistic children.

lookinglass

Why am I not moved, concerned or touched by your defense of yourself Lilady.. Was it meant to evoke compassion and or admiration? This is hardly the place for such declarations. I could suggest therapy might help you.

lilady

lookinglass: I merely corrected your gross error by your assumption that I am in anyway affiliated with LB/RB or any other science blog.

I do not play the "pity me, poor me games" that your pals at AoA play. Unlike your pals at AoA I never have, and I never will, refer to my child as a "train wreck", a "changeling who was stolen" from me.

Your pals at AoA could use some therapy and the ones who subject their children to abuse by pouring bleach into their kids mouths, shoving bleach enemas into them, chelating them and castrating them could use some intervention from Child Protective Services.

lookinglass

"....or any other science blog".......how about that oxymoronic site Respectful Insolence, the one that never mentions science, autism, vaccines or Andrew Wakefield? Oh noooo.....

ASD Researcher

At the 2012 The International Meeting for Autism Research (IMFAR) Harvard Medical researchers presented their findings in regards to Autism and Autoimmune disease to an appreciative audience of researchers , scientists , medical practitioners , paediatricians and the general public.

In this research they investigated autism candidate genes some 717 genes from the Autworks gene database and also ten autoimmune conditions / disorders. Including Inflammatory Bowel Disease and Diabetes Type 1.

They identified over 294 common risk genes ... genes that are significantly shared. In plain english this means that if you have a autism you share a common genetic risk for an autoimmune disease. Including Inflammatory Bowel Disease ...

This is exactly the scientific evidence ...at a genetic level that emphasises the clear factual findings made by John Walker-Smith and Andrew Wakefield in the Lancet paper.

Clearly this would indicate that ASD children have more risk than other children of developing such autoimmune diseases and this is exactly what was found in further research undertaken by researched and medical officers at Harvard Medical and Boston Children's hospital.

They found a significantly increased risk of ASD children developing IBD and Diabetes. They also found an even more significant risk of developing epilepsy , other GI issues and schizophrenia. Particularly in later adulthood.

We do not know what is at the root of these types of significant findings it could be bacterial or viral. It could be a factor within the mother's own auto antibodies and immune system, It could be some other cause ... but what is clear is that those researchers that undertook the Lancet paper were certainly describing their paediatric population to the best of their ability and knowledge at the time.

What critics don't seem to understand is that there is the possibility that vaccines may actually reduce risk (as some evidence suggests) and that if we could understand the mechanisms that underlie that, we can go on to develop better prevention or treatment therapies for those already in need of care.

ndavis

http://rationalwiki.org/wiki/Gish_Gallop

ASD Researcher

http://en.wikipedia.org/wiki/Luddite

lookinglass

Thankyou for all your input here. Most informative and encouraging and refreshingly free of personalised abuse.

Twyla

Yes, thank you so much ASD Researcher.

amdachel

I happy to see that the UW-La Crosse is open to both sides of the controversy. For those interested in the INDEPENDENT RESEARCH on vaccines and their side effects they have only to look at the website for the new film, “The Greater Good,” (See trailer: http://www.youtube.com/watch?v=ulmEGbwQsOU) which explores the question of vaccine safety from both sides.
There are over 200 studies that raise serious concerns about vaccine side effects. http://www.greatergoodmovie.org/learn-more/research/
The medical community and health officials promote vaccines as the greatest achievement in modern medicine yet there is growing fear over vaccine side effects.

Also see the National Vaccine Information Center http://www.nvic.org/,

Anne Dachel, Media editor: Age of Autism http://www.ageofautism.com/

amdachel

Natural health expert, Dr. Mercola, Interviewed Dr. Andrew Wakefield on His MMR Study April 8, 2010 http://www.youtube.com/watch?v=oIsFW5phHas&feature=related.

Anne Dachel, Media editor: Age of Autism http://www.ageofautism.com/.

AutismNewsBeat

Joe Mercola is not a "national health expert." He is a vitamin salesman.

lilady

You're addressing your comments to a bot. See how amdachel flooded the comments here at the same time 7 hours ago with her spam.

amdachel

There are details that were omitted about Andrew Wakefield.
http://www.ageofautism.com/2011/01/gmas-stephanopoulos-walks-over-dr-andrew-wakefield.html
Andrew Wakefield, a British gastroenterologist, urged more study on a disturbing relationship that he was seeing. Parents came to him reporting that their child was healthy until they received the MMR vaccine and suddenly regressed into autism and developed severe bowel disease. We're not told in this story that the British government indemnified the vaccine maker so it's the government that has liability for any damage done by this vaccine.

To hear the stories of the parents of Dr. Wakefield's patients, watch this video http://www.youtube.com/watch?v=cq5BuVHu4Uw.

Anne Dachel, Media editor: Age of Autism http://www.ageofautism.com/.

amdachel

For far too long we've allowed the agency (the Centers for Disease Control and Prevention) that approves, recommends, and vigorously promotes vaccines to also be in charge of vaccine safety. The CDC is also the place where hundreds of individuals have conflict waivers because of their direct financial ties to the vaccine makers. The last head of the CDC, Dr. Julie Gerberding, a long time denier of any link between vaccines and autism, is now the head of the vaccine division at Merck.

Anne Dachel, Media editor: Age of Autism http://www.ageofautism.com/.

amdachel

Listen to Dr. Wakefield talk to CBS reporter, Sharyl Attkisson about vaccines.
Controversy Over Vaccine Research http://www.youtube.com/watch?v=yTh97pANTxc Oct 7, 2009.

Anne Dachel, Media editor: Age of Autism http://www.ageofautism.com/.

AutismNewsBeat

Sharyl Attkisson uncovered evidence of "homologous recombinaltion tiniker,"

http://homologousrecombinaltiontiniker.blogspot.com/

amdachel

I happy to see that the UW-La Crosse is open to both sides of the controversy. For those interested in the INDEPENDENT RESEARCH on vaccines and their side effects they have only to look at the website for the new film, “The Greater Good,” (See trailer: http://www.youtube.com/watch?v=ulmEGbwQsOU) which explores the question of vaccine safety from both sides.
There are over 200 studies that raise serious concerns about vaccine side effects. http://www.greatergoodmovie.org/learn-more/research/
The medical community and health officials promote vaccines as the greatest achievement in modern medicine yet there is growing fear over vaccine side effects.

Also see the National Vaccine Information Center http://www.nvic.org/,

Anne Dachel, Media editor: Age of Autism http://www.ageofautism.com/

amdachel

Talk show host Alex Jones is talked with Dr. Andrew Wakefield
http://www.youtube.com/watch?v=sUpahcqC2OM
Sept, 2011

Anne Dachel, Media editor: Age of Autism http://www.ageofautism.com/.

Merton

Well, I suppose AoA's trajectory into tinfoil-hat land has been apparent for a while, but mentioning Alex Jones with a straight face is a new one on me. "Talk show host"? Think you're leaving a bit out there, Ms. Dachel? Maybe you should go all out and start running ads for "Dark Secrets inside Bohemian Grove."

amdachel

In 2008 CBS News ran the story, How Independent Are Vaccine Defenders?

http://www.cbsnews.com/2100-500690_162-4296175.html

Serious questions were raised about the power and influence of the pharmaceutical industry over groups like the American Academy of Pediatrics when it comes to vaccine safety.

Anne Dachel, Media editor: Age of Autism http://www.ageofautism.com/.

lilady

Here's how Wakefield, the disgraced former doctor, has been undermining the public health system in the United States:

http://blogs.citypages.com/blotter/2011/03/andrew_wakefield_anti-vaccine_somali_measles_outbreak.php

"Last night, disgraced British researcher Andrew Wakefield met with parents from the Somali community to discuss the purported link between autism and childhood vaccinations.

Although reporters were barred from the event, Wakefield's visit coincides with a recent measles outbreak in Minneapolis, in several cases in unvaccinated children.

Wakefield's study, published in 1998, popularized the idea that the measles, mumps and rubella vaccination causes autism in young children. Though the study was denounced as "deliberate fraud" and Wakefield's British medical license revoked, he still has an extremely loyal following.

Wakefield has met with the Minnesotan Somali community before. Rates of diagnoses of autism have risen sharply in the last ten years within the community and Wakefield has visited multiple times looking for support and participants for a future study on Somali children. Anecdotal evidence suggests that vaccinations have dropped substantially within the local Somali community as a direct result of Wakefield's discredited research.

This time, he visited with parents at Safari Restaurant in Minneapolis just as Hennepin County medical officials are dealing with an outbreak of measles. There have been 11 cases reported so far, in patients ranging in age from a four-month-old baby to a 35-year-old. Three of the cases were in unvaccinated Somali children and the state epidemiologist believes the root cause is an unvaccinated Somali child who recently traveled in Kenya."

Here's the MMWR article about the Measles outbreak that occurred in Minneapolis, last year among the Somali community:

http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6013a6.htm

"On March 2, 2011, the Minnesota Department of Health (MDH) confirmed measles in a Hennepin County resident aged 9 months. As of April 1, investigation of contacts and heightened surveillance had revealed a total of 13 epidemiologically linked cases in Hennepin County residents. Of those cases, 11 were laboratory confirmed, and two were in household contacts of confirmed cases and met the clinical case definition for measles.

The patients included children aged 4 months--4 years and one adult aged 51 years; seven of the 13 were of Somali decent. Eight patients were hospitalized. Vaccination status was known for 11 patients: five were too young to have been vaccinated, and six (all of Somali descent) had not been vaccinated because of parental concerns about the safety of the measles, mumps, and rubella (MMR) vaccine. The most recent rash onset was March 28. An additional, unrelated case of measles was confirmed in a Hennepin County resident aged 34 years who was exposed in Orlando, Florida, sometime during March 1--10.

The investigation determined that the index patient was a U.S.-born child of Somali descent, aged 30 months, who developed a rash February 15, 14 days after returning from a trip to Kenya. The patient attended a drop-in child care center 1 day before rash onset; measles developed in three contacts at the center and in one household contact. Secondary and tertiary exposures occurred in two congregate living facilities for homeless persons (four patients), an emergency department (two patients), and households (two patients). A virus isolate from the index patient was genotyped at CDC as B3, which is endemic in sub-Saharan Africa."

His three visits to Minneapolis and discussions with Somali parents are directly responsible for last year's outbreak of measles. He is tangentially responsible for the tens of thousands of cases of measles reported in the U.K. and in Europe. Major outbreaks of measles in unvaccinated children and adults led to the hospitalizations and deaths of children and babies who were too young to have received the vaccine. 25 % of people who acquired measles in France required hospitalization.

Andrew Wakefield is a public health menace.

ndavis

Here's an excellent summary of the Wakefield-MMR debacle:

http://tallguywrites.livejournal.com/148012.html

Here's what Wakefield should have done, if he was honorable:

http://scienceblogs.com/erv/2012/09/19/madness-this-is-science/


AutismNewsBeat

Here's a video that explains the timing and nature of Wakefield's fraud:

http://autism-news-beat.com/archives/1851

ASD Researcher

It is now clear that the John Walker-Smith , Andrew Wakefield work has assisted us greatly in moving forward in the understanding of Autism Spectrum Disorders ASD.

They identified some key knowledge on autism

- immune system is dysfunctional

- there are biological / physiological markers that need to be explored

- the gut interacts with the central nervous system and neurology

- inflammation is present and may be systemic

- environment and genes interact

- viruses or bacteria could play a role

- ASD children can have a better quality of life if gut and inflammation are treated.

*Parents of ASD children reported that their children suffered from severe Gastrointestinal disease that had a strong association with their development , behaviour and language /communication. That they had been observed to be developing normally.

All this was confirmed clinically both by Professor Walker-Smith, Andrew Wakefield and other medical doctors involved in the children's care.

We now know that all the parents observations about their children have also been independently confirmed by the science undertaken since that time, when researchers specifically looked at the physiology of the children.

The regression that these children 'suffered' is confirmed in papers by a team of researchers from Columbia , Harvard and Boston Children's Hospital.

Inflammatory Bowel Disease and other severe GI problems have also been confirmed by Harvard researchers.

Systemic immune system dysfunction has also been confirmed by a large variety of researchers from differing specialities including genetic research undertaken at University of California.

Inflammation has also been confirmed in the brain tissue and other physiology in ASD children and adults by Johns Hopkins researcher Carlos Pardo.

Of clear interest today is the findings that the human gut where a myriad of bacteria and viruses interact is a fundamental part of our immune systems and our health as described recently in Nature science journal special.

What many researchers now acknowledge is that there are differing pathways to that endpoint we define poorly as Autism Spectrum Disorders. Some 30 - 50% may be linked to epilepsy, a further 30% to immune system dysfunction , some to viral activation either prenatal or postnatal (eg rubella , mumps , measles , influenza), some to allergic reactions / mast cells and other environmental triggers.

Many eminent researchers are of the opinion that ASD is an autoimmune or autoinflammatory disease.

Do we as researchers, scientists and medical officers fully understand the roots and pathology of autism. Certainly not. What we understand is complex genes and environment interact ... sometimes in unexpected ways.

ndavis

Your response is quite strange.

For example, you wrote: “The regression that these children 'suffered' is confirmed in papers by a team of researchers from Columbia , Harvard and Boston Children's Hospital.”

In fact, although it remains quite questionable whether many of the Lancet children actually suffered from autistic regression, it should be noted that recent studies clearly suggest that children who experienced autistic regression in the second year of life exhibited abnormal brain development that apparently began during the second trimester of fetal development and was detectable in infancy: Dr. Amaral's group at the UC Davis MIND Institute showed that children who regressed into autism had followed an abnormal trajectory of brain growth that was already apparent by about 4 months of age. Amaral said, “In our cohort, which is about 200 children that we analyzed, [an aberrant pattern of brain growth] is most prominently associated with children that have a regressive form of autism; these are the kids that seem to highlight the vaccine issue, because these children have normal development to 12 to 18 months and then lose social ability and lose language function and regress back into autism . . . so it actually casts doubt on the idea that a vaccine . . . [as] the precipitating factor, because [the abnormal brain growth patterns that Dr. Eric Courchesne has shown begin several months before birth] were starting much, much earlier than that." [see Proc Natl Acad Sci U S A. 2011 December 13; 108(50): 20195–20200]

ASD Researcher

1. "In fact, although it remains quite questionable whether many of the Lancet children actually suffered from autistic regression"

Not according to those researchers specifically looking at ASD children with associative GI disorders - they have found not once but twice in that particular cohort of children an 87 - 88%

"Cases had a high rate of CPEA-defined behavioral regression (loss of language and/or other skills following acquisition), 88%, compared to published rates of 20–40% for the general ASD population."

2. "Dr. Amaral's group at the UC Davis MIND Institute showed that children who regressed into autism had followed an abnormal trajectory of brain growth that was already apparent by about 4 months of age..."

Yes there is a GI phenotype of ASD and a immune related phenotype of ASD do these crossover ? How do they cross over ? When does a child step over the threshold into ASD ?

It is becoming quite clear that there are, as stated before differing pathways to the diagnosis Autism or ASD. I am heartened to see you in agreement that there is an interaction of immune function and neurology. That there are genetic, prenatal and postnatal features is of no surprise to autism researchers , it is indeed a complex process that was certainly not fully understood even as little as a year or two ago let alone some 14 years ago.

Here is Dr Amaral in his own words ...

"DR. DAVID AMARAL: So I think it's pretty clear that, in general, vaccines are not the culprit. There has been enough epidemiological evidence showing that if you look at children that receive the standard childhood vaccines that, if anything, those children are at slightly less risk of having autism than children that aren't immunized.

And so, you know, I think it probably is a waste of effort at this time to try and understand vaccines as a major culprit for, or a major cause of, autism. It's not to say, however, that there is a small subset of children who may be particularly vulnerable to vaccines.

And in their case, having the vaccines, or particular vaccines, particularly in certain kinds of situations -- if the child was ill, if the child had a precondition. Like a mitochondrial defect. Vaccinations for those children actually may be the environmental factor that tipped them over the edge of autism. And I think it is incredibly important, still, to try and figure out what, if any, vulnerabilities, in a small subset of children, might make them at risk for having certain vaccinations."

If ASD is an autoimmune or autoinflammatory disease is this one of the conditons that may lead to 'risk' in the trajectory or pathology of ASD ?

Good questions for science to ask.

Twyla

What epidemiological evidence is Dr. Amaral talking about? I am not aware of studies comparing vaccinated and unvaccinated children, except for a couple of very small rather informal surveys which did show more autism in the vaccinated than in the unvaccinated.

lilady

Links to any citations for all of those statements ASD Researcher?

AutismNewsBeat

The only thing Wakefield got right is that autistic children have intestines.

lilady

Here's the first article written by AoA "Journalist" Ed Arranga. Read it thoroughly to see the vile, vicious defamatory accusations Arranga has leveled against Brian Deer.

http://www.ageofautism.com/2012/09/guess-whos-coming-to-america-brian-deer-to-speak-in-wisconsin-wakefield-press-conference-first.html#more

Mr. Arranga is the head of the Autism One Conference, sponsored by Generation Rescue...which is affiliated with Age of Autism. Generation Rescue's spokesperson is Jenny McCarthy, who has revived her all-but-moribund career as a D-list celeb by "claiming" her son was injured by a vaccine.

Mr. Arranga runs frequent fund-raisers to support Andrew Wakefield since he left the U.K. in disgrace to come to the United States and he is also the head of the Andrew Wakefield Justice Fund.

Deer in the Head Lights

TO NDAVIS. You write like Brian Deer. Full of misdirection and not supported by the facts.

ndavis

Wakefield calculated a jaw-dropping 6.3-day average duration between receipt of MMR vaccine and the onset of behavioral signs of autism—for eight children. Wakefield wrote: “In eight children, the onset of behavioural problems had been linked, either by the parents or by the child's physician, with measles, mumps, and rubella vaccination.”

However, Wakefield specifically EXCLUDED from that calculation three of the other Lancet 12 children, for whom (1) Wakefield recorded above his signature in the child’s chart: “Autistic spectrum disorder and bowel disorder after MMR,” or (2) the child’s “mother linked his mental regression at age 18-20 months to MMR which he was given at 16 months of age,” or (3) “Parents have no doubt about the relationship with MMR.”

If Wakefield had not excluded those children from his calculations, you would never have heard of Wakefield.

Accordingly, you might wonder why a child whose parents emphatically indicated “no doubt about the relationship [of the onset of autistic behavioral signs] with MMR” would have been excluded from Wakefield’s calculation. It happens that removing the data for ONLY that child reduces the average duration between vaccination and the onset of behavioral signs from 56 days to the 14 days that had been accepted as a reasonable window in previous vaccine reaction studies. As Dr. Godlee, the editor of the BMJ, noted: “the discrepancies all led in one direction; misreporting was gross.” [BMJ 2011; 342:c7452]

Could someone please ask Wakefield to explain why the children of parents who clearly indicated that they believed that the the onset of the behavioral signs of autism were temporally linked with the receipt of the MMR vaccine were specifically _excluded_ from Wakefield's infamous calculation of the average time between onset of behavioral signs of autism and the receipt of MMR, if it was not an attempt to dramatically reduce the calculated result?

Thanks.

ASD Researcher

1. "Wakefield calculated a jaw-dropping 6.3-day average duration between receipt of MMR vaccine and the onset of behavioral signs of autism—for eight children."

They were looking at physiological changes as well as neurological changes to the patient. Not autism per se ie fevers , rashes, febrile seizures, sickness behaviours ... those changes in physiology may be consistent with current research surrounding ASD as a disease process ie autoimmune / autoinflammatory state.

2. "Wakefield specifically EXCLUDED from that calculation three of the other Lancet 12 children ..."

Which is made clear in the Lancet paper -

"In eight children, the onset of behavioural problems had been linked, either by the parents or by the child's physician, with measles, mumps, and rubella vaccination. Five had had an early adverse reaction to immunisation (rash, fever, delirium; and, in three cases, convulsions). In these eight children the average interval from exposure to first behavioural symptoms was 6·3 days (range 1—14)."

Those children clearly indicated as children 5, 9, 10 and 12

3. “no doubt about the relationship [of the onset of autistic behavioral signs] with MMR”

The part in brackets [of the onset of autistic behavioral signs] is that your words or the complete words of the parent ?

If it is yours then I must disagree with the emphasis you have placed on a parents words.

ndavis

Could you please indicate where Wakefield explained in his Lancet paper that what he clearly identified as the "first behavioural symptom" of autism should have been understood to include a rash? (Might a pimple be a first behavioural symptom of autism, or does a behavioral sign have to consist of two or more pimples?) Also, please indicate how Wakefield explains that a rash is actually a "behvioural symptom."

Thanks.

ASD Researcher

"They were looking at physiological changes as well as neurological changes to the patient. Not autism per se ie fevers , rashes, febrile seizures, sickness behaviours ... those changes in physiology may be consistent with current research surrounding ASD as a disease process ie autoimmune / autoinflammatory state."

For instance the adverse reactions to vaccines are exhibited both physiologically, neurologically and therefore physically in the behaviour of the patient.

An example of a rash is given which indicates an underlying change to a child's physiology - which in turn leads to changes in neurology and exhibited behaviours. In the case ASD children that are unable to communicate and / or to young to express their underlying pain and distress may lead to such aberrant behaviours as self stimming , head banging and other self injurious behaviours.

You must look at the whole paper within the context of all its components and outlying ecology.

For those interested in the research and a more complex explanation surrounding 'sickness' behaviour' there is a good review paper undertaken by University if Illinois researchers entitiled

Cytokine, sickness behavior, and depression.

"Sufficient evidence is now available to accept the concept that the brain recognizes cytokines as molecular signals of sickness. Clarifying the way the brain processes information generated by the innate immune system is accompanied by a progressive elucidation of the cellular and molecular components of the intricate system that mediates cytokine-induced sickness behavior. We are still far, however, from understanding the whole. Among the hundreds of genes that proinflammatory cytokines can induce in their cellular targets, only a handful has been examined functionally. In addition, a dynamic view of the cellular interactions that occur at the brain sites of cytokine production and action is missing, together with a clarification of the mechanisms that favor the transition toward pathology.

Anyone who has experienced an episode of viral or bacterial infection knows well the subjective feelings of sickness, in the form of malaise, lassitude, fatigue, numbness, coldness, muscle and joint aches, and reduced appetite. Because they are common, these symptoms usually are ignored by physicians. They are considered uncomfortable, but banal, components of the pathogen-induced debilitation process that affects sick individuals.

This simplistic view has turned out to be incorrect. The psychologic and behavioral components of sickness represent, together with fever response and associated neuroendocrine changes, a highly organized strategy of the organism to fight infection [1]. This strategy, referred to as “sickness behavior,” is triggered by the proinflammatory cytokines produced by activated cells of the innate immune system in contact with specific pathogen-associated molecular patterns (PAMPs). These cytokines include mainly interleukin (IL) 1 (IL-1α and IL-1β), IL-6, and tumor necrosis factor α (TNF-α)."


ASD Researcher

...which naturally leads us to the question whether a differing cytokines profile is present in ASD children .. ie are they sick ?

"The aim of the study was to analyze cytokine profiles in neonatal dried blood samples (n-DBSS) retrieved from The Danish Newborn Screening Biobank of children developing Autism Spectrum Disorders (ASD) later in life and controls.

Samples of 359 ASD cases and 741 controls were analyzed using Luminex xMAP technology and clinical data were retrieved from nationwide registers. Findings showed that children developing

ASD were more likely to have decreased levels of both T helper-1(Th-1)-like cytokines (i.e. IFN-γ) and Th-2like cytokines (i.e. IL-4, IL-10) which may suggest a depressed or hypoactive immune cell activity during neonatal period in ASD."

Once again form the neonatal environment we can see that ASD children have a unique immune profile that shows quite clearly their immune system is in some sort of dysfunction and this suggests it continues into adulthood and links quite probably to such co-morbid conditions as Inflammatory Bowel Disease, Diabetes and even schizophrenia. It certainly may well explain anxiety and depression profiles in ASD children and adults.

nhokkanen

Judges in Rimini, north-east Italy awarded the Bocca family Euros 174,000 (£140,000) after the Italian Health Ministry conceded the MMR vaccine caused autism in their nine-year-old son Valentino.
Up to 100 similar cases are now being examined by Italian lawyers and experts suggest the case could lead to other families pursuing cases.
(June 2012)
http://www.independent.co.uk/life-style/health-and-families/health-news/italian-court-reignites-mmr-vaccine-debate-after-award-over-child-with-autism-7858596.html

Science Mom

@ nhokkanen, The Italian decision was based upon Wakefield's fraudulent studies. It's been roundly criticised from a legal and medical standpoint and is being challenged. And as for your Daily Fail article, guess what? It ain't autism and it's known that there are rare and severe adverse effects from vaccines. And eating and driving and riding a bike. Grasping at straws doesn't support your claims.

BeckyFisher

"Andrew Wakefield, the English doctor who championed the now-dismissed link between the measles-mumps-rubella vaccine and the onset of autism,"

This article gets it wrong in the second sentence! The Lancet paper did not "champion" a vaccine/autism link. And the link between autism and vaccines is far from "dismissed."

AutismNewsBeat

Wakefield also claimed an association between MMR and autism in his 1997 patent application. He has made similar assertions over the years in press interviews.

Yellowriver

Are you proud of your site Becky Fisher aka Brian Deer aka Rebecca Fisher.
http://jabsloonies.blogspot.co.uk/

nhokkanen

Family win 18 year fight over MMR damage to son
Robert Fletcher, 18, is unable to talk, stand unaided or feed himself. (2010)
http://www.dailymail.co.uk/news/article-1307095/Family-win-18-year-fight-MMR-damage-son--90-000-payout-concerns-vaccine-surfaced.html

ndavis

You seem to want to dwell on legal opinions versus the clear consensus based on the scientific evidence. That's a bad idea if you hope to convince anyone that your position is not ridiculous..

For example you might want to consider the thousands of cases that were denied compensation by the Autism Omnibus Proceeding, in addition to this:

It happens that in the case that you mentioned, Fletcher's condition is strikingly similar to what you would expect from certain genetic syndromes that emerge in childhood following a period of apparently normal development. A study of allegedly vaccine-injured children with histories like Fletcher's showed that almost all of the children examined had mutations within one particular gene that is a member of a ‘family’ of genes associated with such syndromes, and the rest had clearly-defined epilepsy syndromes associated with members of that gene family. FWIW, the only practicing physician on the panel that heard Fletcher's case happened to be a pediatrician (the other members were a lawyer and a retired urologic surgeon) who would be expected to have more knowledge and experience related to syndromes that emerge in childhood than could be expected of, say, a lawyer or a retired urologic surgeon. That pediatrician stated that Fletcher's alleged vaccine injury was in fact genetic in origin and that he would have developed the same problems whether or not he had been vaccinated, but she was overruled by the other two, clearly less-knowledgeable two panelists, who indicated that they relied on the evidence that Fletcher's problems (just like the problems of the allegedly 'vaccine-injured' children who turned out to have causal mutations) HAPPENED TO EMERGE following vaccination. Thus, the scientific evidence was rejected by those who were unfamiliar with the scientific evidence--but you think this is laudable?

ASD Researcher

ndavis may be alluding to the linkage between SCN1A a gene with a as yet undefined relationship with autism.

University of Hong Kong researchers recently found in a cohort of children with SCN1A - "79% (11/14) of DS patients with SCN1A mutations had features which fit into the diagnostic criteria of autism spectrum disorder (ASD). 57% (8/14) had history of vaccination-induced seizures."

This is an important research outcome that underlies once again the seriousness of taking parental observations into account.

Washington University scientists have been undertaking research in treatment regimes. They reported recently -

"treatment with low-dose clonazepam, a positive allosteric modulator of GABAA receptors, completely rescued the abnormal social behaviours and deficits in fear memory in the mouse model of Dravet’s syndrome, demonstrating that they are caused by impaired GABAergic neurotransmission and not by neuronal damage from recurrent seizures."

This indicates a complex relationships between SCN1A and autism, as well SCN1A's reationship to seizure acitivity. As such I think we can all agree that it needs further robust investigation.

It is worth noting the many interactions and high co-morbidity of seizures and autism and other health outcomes.

* Children with current reported epilepsy/seizure disorder were significantly more likely than those never diagnosed to

experience depression (8% vs 2%),

anxiety (17% vs 3%),

attention-deficit/hyperactivity disorder (23% vs 6%),

conduct problems (16% vs 3%),

developmental delay (51% vs 3%), (Fisher at al posted above 84% to borderline)

autism/autism spectrum disorder (16% vs 1%), (Fisher at al 37%)

and headaches (14% vs 5%) (all P < .05).

ndavis

Indeed, SCN1A mutations seem a likely explanation for many supposed vaccine injuries, in particular those that seem temporally related to receipt of DTP and also MMR. It's worth noting that the pattern of the the expression of the mutant gene explains why seizure activity and the development of autistic traits emerge following a period of apparently normal development. Notably, the abnormal neurodevelopment occurs in never-vaccinated rodents as well as in children. The recent Nature paper that you mentioned clearly indicates that it is the mutation, and not vaccine-associated (febrile) seizure that is causative.

ASD Researcher

1. I'm not sure I could express it more clearly ...

"This indicates a complex relationships between SCN1A and autism, as well SCN1A's reationship to seizure acitivity. As such I think we can all agree that it needs further robust investigation."

That there is a genetic vulnerability is common sense both scientifically , medically and logically.

"It's worth noting that the pattern of the the expression of the mutant gene explains why seizure activity and the development of autistic traits emerge following a period of apparently normal development."

Parent observations were correct.

Genes have a role in autism.

Genes have differing roles in human physiology and neurology in this case both seizures , immune pathways and neurology.

Vaccines can initiate genetic expression.

2. "Notably, the abnormal neurodevelopment occurs in never-vaccinated rodents as well as in children."

Yes the previous noted research shows -

"79% (11/14) of DS patients with SCN1A mutations had features which fit into the diagnostic criteria of autism spectrum disorder (ASD)."

That also "expresses" that 21% did not

"57% (8/14) had history of vaccination-induced seizures."

That also expresses that 43% did not ...

3. "The recent Nature paper that you mentioned clearly indicates that it is the mutation, and not vaccine-associated (febrile) seizure that is causative."

It is obvious that genes have more than one function ... that gene networks interact ... and that we do not fully understand the complete interactions.

We also do not know what interactions underlie why vaccines 'trigger' this particular gene.

ndavis

Could someone who attends Wakefield’s press conference please ask him a few questions?

(1) Since the parents of 11 of the 12 children that you discussed in your Lancet paper clearly indicated that they believed that receipt of MMR was associated with regression, why did you choose to include only 8 children in your analysis? Since omission of those 3 children from your calculation very dramatically reduced average interval between receipt of MMR to the calculated duration until the development of first signs, if you did not omit those children from your calculation in an attempt to skew your results, then why did you do it? Did you just forget?
(2) Why did you change the timing of onset of symptoms for several of the children between your August 1997 draft and the final draft of the paper that you submitted a few months later, if it was not in an attempt to reduce the average duration of the time between receipt of MMR and the onset of symptoms? Were those just inadvertent typographical errors, were you simply unable to keep track of the data for a dozen children, or was there some other explanation?
(3) When the senior clinician, Dr. Walker-Smith indicated in formal ward rounds that one the Lancet children was not to have a lumbar puncture or colonoscopy because neither procedure was clinically indicated, why did that child undergo both procedures, given that (a) although you did not have a clinical appointment and you did not have any pediatric qualification, you nevertheless ordered tests above your signature in the chart of that child, and (b) your research protocol specifically indicated that the vulnerable children should undergo potentially dangerous procedures such as lumbar puncture and colonoscopy only if they were clinically indicated?
(4) Since, according to the Royal College of Surgeons you have not paid your dues since 1996 and you are not a member, why do you think that you are not dishonest when you identify yourself in legal documents as a fellow of that college?